在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. Phospho-RPH3A (S237) Antibody

Phospho-RPH3A (S237) Antibody

  • 中文名稱：
    磷酸化-RPH3A (S237)兔多克隆抗體
  • 貨號：
    CSB-PA008274
  • 規格：
    ￥1090
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    RPH3A
  • 別名：
    Exophilin 1 antibody; Exophilin-1 antibody; Exophilin1 antibody; KIAA0985 antibody; Rabphilin 3A homolog antibody; Rabphilin-3A antibody; Rabphilin3A antibody; RP3A antibody; RP3A_HUMAN antibody; Rph 3a antibody; Rph3a antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human Rabphilin-3A around the phosphorylation site of S237.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays an essential role in docking and fusion steps of regulated exocytosis. At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release. In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Plays also a role in the exocytosis of arginine vasopressin hormone.
  • 基因功能參考文獻：
    1. Findings indicate that Rph3A activity is linked to the aberrant synaptic localization of GluN2A-expressing NMDARs characterizing levodopa-induced dyskinesias; suggest that Rph3A/GluN2A complex could represent an innovative therapeutic target for those pathological conditions where NMDAR composition is significantly altered. PMID: 28823933
    2. Rabphilin-3A is a major autoantigen in Lymphocytic infundibulo-neurohypophysitis (LINH). Autoantibodies to rabphilin-3A may serve as biomarker for the diagnosis of LINH and be useful for the differential diagnosis of Central diabetes insipidus. PMID: 25919460
    3. rabphilin 3A loss correlated with dementia severity, cholinergic deafferentation, and increased beta-amyloid concentrations PMID: 24200817
    4. Structural insights into the Ca2+ and PI(4,5)P2 binding modes of the C2 domains of rabphilin 3A and synaptotagmin 1. PMID: 24302762
    5. Rabphilin-3A and Rab3A are present in normal mouse, rat, and human kidneys, with an exclusively glomerular expression and a comma-like pattern of positivity along the glomerular capillary wall, suggestive for podocyte staining. PMID: 12937130
    6. Since rab3a participates in the docking and fusion of synaptic vesicles, and rabsa binding to alpha-synuclein is increased in Lewy body disease (LBD), it can be suggested that exocytosis of neurotransmitters may be impaired in LBD. PMID: 15207266
    7. We found a reduction in rabphilin 3a, a protein involved in vesicle docking and recycling, in Huntington disease[HD] brains of grade III and IV. A deficient pre-synaptic transmitter release may underlie some symptoms of HD. PMID: 17877635

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic cell membrane. Membrane; Peripheral membrane protein.
  • 數據庫鏈接：

    HGNC: 17056

    OMIM: 612159

    KEGG: hsa:22895

    STRING: 9606.ENSP00000374036

    UniGene: Hs.21239



主站蜘蛛池模板： 亚洲欧洲日本综合aⅴ在线| 久久av无码αv高潮αv喷吹| 特黄大片又粗又大又暴| 夜夜未满十八勿进的爽爽影院| 亚洲精品无码久久千人斩| 四川骚妇无套内射舔了更爽| 久久午夜无码鲁丝片直播午夜精品 | 人人妻人人爽人人做夜欢视频| 亚洲欧洲日本无在线码| 国产成人精品一区二区不卡| 久久精品99国产精品日本| 亚洲视频在线观看| 国产午夜精品理论片| 国产高潮流白浆免费观看| 中文无码第3页不卡av| 天天躁夜夜躁狠狠是什么心态 | 无遮挡18禁啪啪免费观看| 亚洲熟妇丰满多毛xxxx| 国产精品久久久久7777| 华人在线亚洲欧美精品| 国产福利永久在线视频无毒不卡| 肥臀熟女一区二区三区| 国产精品对白交换视频| 亚洲中文字幕码在线电影| 少妇激情作爱视频| 亚洲精品高清无码视频| 欧美色就是色| 久久婷婷五月综合中文字幕| 日本中文字幕乱码免费| 青青青国产精品一区二区| 欧美性生交xxxxx久久久| 日日天日日夜日日摸| 久久精品中文字幕有码| 国产亚洲视频中文字幕97精品| 欧美高清精品一区二区| 日韩人妻无码精品专区综合网| 国产偷国产偷亚洲高清app| 精品国产乱码久久久久久1区2区| 国产69囗曝吞精在线视频| 国产裸体歌舞一区二区| 人妻少妇中文字幕久久|