在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RPH3A Antibody

  • 中文名稱:
    RPH3A兔多克隆抗體
  • 貨號:
    CSB-PA020102GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    RPH3A
  • 別名:
    Exophilin 1 antibody; Exophilin-1 antibody; Exophilin1 antibody; KIAA0985 antibody; Rabphilin 3A homolog antibody; Rabphilin-3A antibody; Rabphilin3A antibody; RP3A antibody; RP3A_HUMAN antibody; Rph 3a antibody; Rph3a antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human RPH3A
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays an essential role in docking and fusion steps of regulated exocytosis. At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release. In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Plays also a role in the exocytosis of arginine vasopressin hormone.
  • 基因功能參考文獻:
    1. Findings indicate that Rph3A activity is linked to the aberrant synaptic localization of GluN2A-expressing NMDARs characterizing levodopa-induced dyskinesias; suggest that Rph3A/GluN2A complex could represent an innovative therapeutic target for those pathological conditions where NMDAR composition is significantly altered. PMID: 28823933
    2. Rabphilin-3A is a major autoantigen in Lymphocytic infundibulo-neurohypophysitis (LINH). Autoantibodies to rabphilin-3A may serve as biomarker for the diagnosis of LINH and be useful for the differential diagnosis of Central diabetes insipidus. PMID: 25919460
    3. rabphilin 3A loss correlated with dementia severity, cholinergic deafferentation, and increased beta-amyloid concentrations PMID: 24200817
    4. Structural insights into the Ca2+ and PI(4,5)P2 binding modes of the C2 domains of rabphilin 3A and synaptotagmin 1. PMID: 24302762
    5. Rabphilin-3A and Rab3A are present in normal mouse, rat, and human kidneys, with an exclusively glomerular expression and a comma-like pattern of positivity along the glomerular capillary wall, suggestive for podocyte staining. PMID: 12937130
    6. Since rab3a participates in the docking and fusion of synaptic vesicles, and rabsa binding to alpha-synuclein is increased in Lewy body disease (LBD), it can be suggested that exocytosis of neurotransmitters may be impaired in LBD. PMID: 15207266
    7. We found a reduction in rabphilin 3a, a protein involved in vesicle docking and recycling, in Huntington disease[HD] brains of grade III and IV. A deficient pre-synaptic transmitter release may underlie some symptoms of HD. PMID: 17877635

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic cell membrane. Membrane; Peripheral membrane protein.
  • 數據庫鏈接:

    HGNC: 17056

    OMIM: 612159

    KEGG: hsa:22895

    STRING: 9606.ENSP00000374036

    UniGene: Hs.21239



主站蜘蛛池模板: av无码免费岛国动作片片段欣赏网| 97精品人人a片免费看| 中国凸偷窥xxxx自由视频妇科| 男女后式激烈动态图片| 中文字幕乱码免费看电影| 国产精品无码无卡无需播放器| 香蕉精品亚洲二区在线观看| 中文人妻无码一区二区三区在线| 日韩欧美激情兽交| www夜片内射视频在观看视频| 久久久久99精品国产片| 少妇真实被内射视频三四区| 忘忧草日本在线www| 亚洲国产精品久久久天堂不卡海量 | 成人做受黄大片| 中文字幕人成乱码熟女app| 免费无遮挡无码视频网站| 婷婷五月开心亚洲综合在线| 太深太粗太爽太猛了视频免费观看| 自拍偷自拍亚洲精品情侣| 国模无码一区二区三区| 国产av一区二区三区无码野战| 国产男女嘿咻视频在线观看| 国色天香社区视频| 国产精品极品美女自在线观看免费| 波多野结衣av一区二区全免费观看 | 亚洲狠狠婷婷综合久久| 国产乱子伦农村叉叉叉| 国产精品无码a∨果冻传媒| 亚洲精品无码av中文字幕| 亚洲精品一区久久久久一品av| 人妻丰满熟妇av无码区hd| 色一乱一伦一图一区二区精品| 亚洲国产成人第一天堂| 国产精品毛片久久久久久久| 亚洲人成网站观看在线播放 | 国产丰满人妻一区二区| 亚洲精品一区三区三区在线观看| 久久婷婷五月综合97色直播| 久久精品国产只有精品66| 国产精品涩涩涩视频网站|