在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Protein argonaute-3 (EIF2C3), partial

  • 中文名稱:
    Recombinant Human Protein argonaute-3(EIF2C3) ,partial
  • 貨號:
    CSB-YP875700HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human Protein argonaute-3(EIF2C3) ,partial
  • 貨號:
    CSB-EP875700HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Human Protein argonaute-3(EIF2C3) ,partial
  • 貨號:
    CSB-EP875700HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human Protein argonaute-3(EIF2C3) ,partial
  • 貨號:
    CSB-BP875700HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human Protein argonaute-3(EIF2C3) ,partial
  • 貨號:
    CSB-MP875700HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    AGO3
  • Uniprot No.:
  • 別名:
    5730550L01Rik; Ago 3; Ago3; AGO3_HUMAN; argonaute 3; Argonaute3; eIF 2C 3; eIF-2C 3; eIF2C 3; Eif2c3; EIF2C3 protein; Eukaryotic translation initiation factor 2C 3; Eukaryotic translation initiation factor 2C3; FLJ12765; hAgo3; MGC86946; Protein argonaute-3
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent siRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity.
  • 基因功能參考文獻:
    1. Data show that recombinant AGO3 loaded with miR-20a cleaves complementary target RNAs. PMID: 29040713
    2. Study uncovers a first example of a vertebrate protein factor, Argonaute-3, specifically affecting the guide-to-passenger-strand ratio of the miRNA let-7a. A multi-layered mechanism for the observed impact of Ago3 on the let-7a-3p passenger strand expression and activity is proposed. PMID: 24100239
    3. The N-terminal domain of Ago3 inhibits cleavage activity. AAs 1-64 are largely unstructured & form a large loop surrounding an area containing two helices & another unstructured loop. PMID: 23665583
    4. The Ago3 PIWI domain is slicing competent but our Ago3 model suggests multiple interactions between residues in the PIWI & N domains that may increase protein rigidity or invoke other properties that contribute to Ago3's observed slicing deficiency. PMID: 23748378
    5. DICER- and AGO3-dependent generation of retinoic acid-induced DR2 Alu RNAs regulates human stem cell proliferation. PMID: 23064648
    6. Ago3 is able to load microRNAs efficiently in the absence of Ago1 and Ago2, despite a significant loss of global microRNA expression PMID: 22474261
    7. reliable predictions of miRNA affinity to Ago2 AND Ago3 proteins were made. PMID: 21634124
    8. The specificity of RNA interference depends on the concentration of Ago1, Ago3, and Ago4 relative to Ago2. PMID: 18771919
    9. EIF@C3 protein is expressed in both Schwann and neuron-type differentiating cells. PMID: 19393748

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, P-body.
  • 蛋白家族:
    Argonaute family, Ago subfamily
  • 數據庫鏈接:

    HGNC: 18421

    OMIM: 607355

    KEGG: hsa:192669

    STRING: 9606.ENSP00000362287

    UniGene: Hs.657659



主站蜘蛛池模板: 中国china露脸自拍性hd| 六月丁香亚洲综合在线视频| 丰满无码人妻热妇无码区| 在线观看免费人成视频| 亚洲精品国产品国语在线| 爽死你欧美大白屁股在线| 99精品国产高清一区二区麻豆| 亚洲日本成本人观看| 97久久国产亚洲精品超碰热| 国产人妻高清国产拍精品| 亚洲精品国产高清在线观看| 极品人妻videosss人妻| 成年女人18级毛片毛片免费| 亚洲2021av天堂手机版| 成人免费午夜无码视频| 久久精品国产精品亚洲毛片| 无尺码精品产品视频| 国产一区二区三区在线视頻| 亚洲国产一区二区精品无码| 无码高潮少妇毛多水多水| 奇米影视777四色米奇影院| 麻豆国产在线精品国偷产拍| 精品无人乱码高清在线观看 | 青青草视频在线观看| 无码高潮少妇毛多水多水免费| 少女高清影视在线观看动漫| 成人奭片免费观看| 精品无码无人网站免费视频| 色婷婷国产精品高潮呻吟av久久| 亚洲精品国产自在现线最新| 天天天天躁天天爱天天碰2018| 美女扒开尿口让男人桶| 国产无套粉嫩白浆在线| 国产剧情无码播放在线看| 亚洲综合久久一区二区| 久久99精品国产.久久久久| 日韩免费码中文在线观看| 无码国产精品一区二区免费16| 国产成人精品男人的天堂| 两性色午夜视频免费老司机| 亚洲狠狠婷婷综合久久久久图片|