在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. AGO3 Antibody, Biotin conjugated

AGO3 Antibody, Biotin conjugated

  • 中文名稱(chēng)：
    AGO3兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA875700LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：
    Rabbit anti-Homo sapiens (Human) AGO3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    AGO3
  • 別名：
    Protein argonaute-3 (Argonaute3) (hAgo3) (Argonaute RISC catalytic component 3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3), AGO3, EIF2C3
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Protein argonaute-3 protein (251-400aa)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類(lèi)型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent siRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity.
  • 基因功能參考文獻(xiàn)：
    1. Data show that recombinant AGO3 loaded with miR-20a cleaves complementary target RNAs. PMID: 29040713
    2. Study uncovers a first example of a vertebrate protein factor, Argonaute-3, specifically affecting the guide-to-passenger-strand ratio of the miRNA let-7a. A multi-layered mechanism for the observed impact of Ago3 on the let-7a-3p passenger strand expression and activity is proposed. PMID: 24100239
    3. The N-terminal domain of Ago3 inhibits cleavage activity. AAs 1-64 are largely unstructured & form a large loop surrounding an area containing two helices & another unstructured loop. PMID: 23665583
    4. The Ago3 PIWI domain is slicing competent but our Ago3 model suggests multiple interactions between residues in the PIWI & N domains that may increase protein rigidity or invoke other properties that contribute to Ago3's observed slicing deficiency. PMID: 23748378
    5. DICER- and AGO3-dependent generation of retinoic acid-induced DR2 Alu RNAs regulates human stem cell proliferation. PMID: 23064648
    6. Ago3 is able to load microRNAs efficiently in the absence of Ago1 and Ago2, despite a significant loss of global microRNA expression PMID: 22474261
    7. reliable predictions of miRNA affinity to Ago2 AND Ago3 proteins were made. PMID: 21634124
    8. The specificity of RNA interference depends on the concentration of Ago1, Ago3, and Ago4 relative to Ago2. PMID: 18771919
    9. EIF@C3 protein is expressed in both Schwann and neuron-type differentiating cells. PMID: 19393748

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm, P-body.
  • 蛋白家族：
    Argonaute family, Ago subfamily
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 18421

    OMIM: 607355

    KEGG: hsa:192669

    STRING: 9606.ENSP00000362287

    UniGene: Hs.657659



主站蜘蛛池模板： 国产又色又爽又黄刺激在线视频| 怡红院成永久免费人视频新的| 激情爆乳一区二区三区| 五月花成人网| 人妻少妇邻居少妇好多水在线 | 乱人伦人妻中文字幕| 最新永久无码av网址亚洲| 成年女人片免费视频播放a| 亚洲国产精品无码观看久久| 一区二区三区无码被窝影院| 国产精品被窝福利一区| 免费精品国偷自产在线2020| 无码精品人妻一区二区三区湄公河 | 久久久久无码精品国产人妻无码| 欧美亚洲另类自拍丝袜| 国产日韩成人内射视频| 一性一交一口添一摸视频| 伦理片午夜视频在线观看| 丰满的少妇hd高清中文字幕| 一边摸一边抽搐一进一出视频| 在线观看的网站| 国产精品国产午夜免费看福利| 丰满多毛少妇做爰视频爽爽和| 国内精品人妻久久毛片app| 欧美亅性猛交内射| 亚洲中文字慕日产2021| 色欲色香天天天综合vvv| 成人综合网站| 国产精品麻豆成人av网| 中文字幕久热精品视频在线| 丰满人妻妇伦又伦精品国产| 婷婷丁香六月激情综合在线人| 国内丰满熟女出轨videos| 久久久久久久99精品免费观看| 美女内射视频www网站午夜| 国产精品69人妻无码久久| 亚洲综合色无码| 波多野结衣av无码| 成人性三级欧美在线观看| 99久久精品国产波多野结衣| 国产亚洲精品a在线无码|