在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. AGO3 Antibody, FITC conjugated

AGO3 Antibody, FITC conjugated

  • 中文名稱：
    AGO3兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA875700LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) AGO3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    AGO3
  • 別名：
    Protein argonaute-3 (Argonaute3) (hAgo3) (Argonaute RISC catalytic component 3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3), AGO3, EIF2C3
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Protein argonaute-3 protein (251-400aa)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent siRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity.
  • 基因功能參考文獻：
    1. Data show that recombinant AGO3 loaded with miR-20a cleaves complementary target RNAs. PMID: 29040713
    2. Study uncovers a first example of a vertebrate protein factor, Argonaute-3, specifically affecting the guide-to-passenger-strand ratio of the miRNA let-7a. A multi-layered mechanism for the observed impact of Ago3 on the let-7a-3p passenger strand expression and activity is proposed. PMID: 24100239
    3. The N-terminal domain of Ago3 inhibits cleavage activity. AAs 1-64 are largely unstructured & form a large loop surrounding an area containing two helices & another unstructured loop. PMID: 23665583
    4. The Ago3 PIWI domain is slicing competent but our Ago3 model suggests multiple interactions between residues in the PIWI & N domains that may increase protein rigidity or invoke other properties that contribute to Ago3's observed slicing deficiency. PMID: 23748378
    5. DICER- and AGO3-dependent generation of retinoic acid-induced DR2 Alu RNAs regulates human stem cell proliferation. PMID: 23064648
    6. Ago3 is able to load microRNAs efficiently in the absence of Ago1 and Ago2, despite a significant loss of global microRNA expression PMID: 22474261
    7. reliable predictions of miRNA affinity to Ago2 AND Ago3 proteins were made. PMID: 21634124
    8. The specificity of RNA interference depends on the concentration of Ago1, Ago3, and Ago4 relative to Ago2. PMID: 18771919
    9. EIF@C3 protein is expressed in both Schwann and neuron-type differentiating cells. PMID: 19393748

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, P-body.
  • 蛋白家族：
    Argonaute family, Ago subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18421

    OMIM: 607355

    KEGG: hsa:192669

    STRING: 9606.ENSP00000362287

    UniGene: Hs.657659



主站蜘蛛池模板： 天堂mv在线mv免费mv香蕉| 亚洲国产欧美国产综合久久 | 人人妻人人爽日日人人| av一区二区国产在线视频| 97国产一区二区三区四区久久| 免费精品国产自在| 在线观看人成视频免费| 日韩 欧美 动漫 国产 制服| 欧美大浪妇猛交饥渴大叫| 成年女人免费v片| 伊人无码一区二区三区| 人人妻人人爽人人添夜夜欢视频| 欧美另类人妖| 国产亚av手机在线观看| 一线二线三线天堂| 青草影院内射中出高潮-百度| 97视频热人人精品免费| 国产亚洲日韩欧美另类丝瓜app| 欧美肥老太交性506070| 男人j进入女人j内部免费网站| 国内揄拍国内精品少妇国语| 国产无夜激无码av毛片| 国产亚洲欧美日韩精品一区二区| 婷婷丁香六月激情综合啪| 1000部夫妻午夜免费| 无码夜色一区二区三区| 亚洲不卡av不卡一区二区| 又爽又色禁片1000视频免费看| 国产在线视频一区二区三区98| аⅴ资源天堂资源库在线| 丰满的人妻hd高清日本| 国产精品主播一区二区三区| 精品欧美小视频在线观看| 四虎影视在线影院在线观看免费视频 | 欧美一区内射最近更新| 真人做人试看60分钟免费视频| 美国特级a毛片免费网站| 好硬好湿好爽再深一点动态图视频| 日本丰满少妇裸体自慰| 色悠久久久久综合欧美99| 国产成人年无码av片在线观看|