在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. AGO3 Antibody, FITC conjugated

AGO3 Antibody, FITC conjugated

  • 中文名稱：
    AGO3兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA875700LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) AGO3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    AGO3
  • 別名：
    Protein argonaute-3 (Argonaute3) (hAgo3) (Argonaute RISC catalytic component 3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3), AGO3, EIF2C3
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Protein argonaute-3 protein (251-400aa)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent siRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity.
  • 基因功能參考文獻：
    1. Data show that recombinant AGO3 loaded with miR-20a cleaves complementary target RNAs. PMID: 29040713
    2. Study uncovers a first example of a vertebrate protein factor, Argonaute-3, specifically affecting the guide-to-passenger-strand ratio of the miRNA let-7a. A multi-layered mechanism for the observed impact of Ago3 on the let-7a-3p passenger strand expression and activity is proposed. PMID: 24100239
    3. The N-terminal domain of Ago3 inhibits cleavage activity. AAs 1-64 are largely unstructured & form a large loop surrounding an area containing two helices & another unstructured loop. PMID: 23665583
    4. The Ago3 PIWI domain is slicing competent but our Ago3 model suggests multiple interactions between residues in the PIWI & N domains that may increase protein rigidity or invoke other properties that contribute to Ago3's observed slicing deficiency. PMID: 23748378
    5. DICER- and AGO3-dependent generation of retinoic acid-induced DR2 Alu RNAs regulates human stem cell proliferation. PMID: 23064648
    6. Ago3 is able to load microRNAs efficiently in the absence of Ago1 and Ago2, despite a significant loss of global microRNA expression PMID: 22474261
    7. reliable predictions of miRNA affinity to Ago2 AND Ago3 proteins were made. PMID: 21634124
    8. The specificity of RNA interference depends on the concentration of Ago1, Ago3, and Ago4 relative to Ago2. PMID: 18771919
    9. EIF@C3 protein is expressed in both Schwann and neuron-type differentiating cells. PMID: 19393748

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, P-body.
  • 蛋白家族：
    Argonaute family, Ago subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18421

    OMIM: 607355

    KEGG: hsa:192669

    STRING: 9606.ENSP00000362287

    UniGene: Hs.657659



主站蜘蛛池模板： 亚洲中文有码字幕青青| 久久久久欧美精品| av亚欧洲日产国码无码| 亚洲精品成人久久电影网 | 大香线蕉伊人精品超碰| 日本少妇人妻xxxxx18| 亚洲线精品一区二区三区影音先锋| 亚洲另类春色校园小说| 日韩精品久久久肉伦网站| 97超碰国产精品无码分类| 日本xxxx片免费观看| 精品国产av 无码一区二区三区| 国产一区二区三区四区五区vm| 亚洲午夜无码久久久久小说| 国产69精品久久久久乱码韩国 | 69sex久久精品国产麻豆| 精品久久久久久无码专区| 少妇高潮喷水在线观看| 性色av无码专区一ⅴa亚洲| 日韩精品无码熟人妻视频| 国产精品丝袜一区二区三区| 亚洲人成电影网站色| 亚洲欧美v国产一区二区| 欧美熟妇色ⅹxxx欧美妇| 久久人人爽人人爽人人片| 免费无码av片在线观看潮喷| 欧洲熟妇色xxxx欧美老妇软件| 欧美黑人又大又粗xxxxx| 日韩无套内射视频6| 两个男人吮她的花蒂和奶水视频| 国精产品一品二品国精在线观看| 秋霞国产午夜伦午夜福利片| 小12萝裸体视频国产| 精品无码国产自产在线观看水浒传 | 国产卡一卡二卡三精品| 国产成人精品日本亚洲第一区| 亚洲aⅴ无码国精品中文字慕 | 久久久久亚洲精品无码网址 | 日韩精品久久无码人妻中文字幕| 久久影视久久午夜| 国产精品亚洲二区在线播放|