在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. AGO3 Antibody, HRP conjugated

AGO3 Antibody, HRP conjugated

  • 中文名稱：
    AGO3兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA875700LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) AGO3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    AGO3
  • 別名：
    Protein argonaute-3 (Argonaute3) (hAgo3) (Argonaute RISC catalytic component 3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3), AGO3, EIF2C3
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Protein argonaute-3 protein (251-400aa)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent siRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity.
  • 基因功能參考文獻：
    1. Data show that recombinant AGO3 loaded with miR-20a cleaves complementary target RNAs. PMID: 29040713
    2. Study uncovers a first example of a vertebrate protein factor, Argonaute-3, specifically affecting the guide-to-passenger-strand ratio of the miRNA let-7a. A multi-layered mechanism for the observed impact of Ago3 on the let-7a-3p passenger strand expression and activity is proposed. PMID: 24100239
    3. The N-terminal domain of Ago3 inhibits cleavage activity. AAs 1-64 are largely unstructured & form a large loop surrounding an area containing two helices & another unstructured loop. PMID: 23665583
    4. The Ago3 PIWI domain is slicing competent but our Ago3 model suggests multiple interactions between residues in the PIWI & N domains that may increase protein rigidity or invoke other properties that contribute to Ago3's observed slicing deficiency. PMID: 23748378
    5. DICER- and AGO3-dependent generation of retinoic acid-induced DR2 Alu RNAs regulates human stem cell proliferation. PMID: 23064648
    6. Ago3 is able to load microRNAs efficiently in the absence of Ago1 and Ago2, despite a significant loss of global microRNA expression PMID: 22474261
    7. reliable predictions of miRNA affinity to Ago2 AND Ago3 proteins were made. PMID: 21634124
    8. The specificity of RNA interference depends on the concentration of Ago1, Ago3, and Ago4 relative to Ago2. PMID: 18771919
    9. EIF@C3 protein is expressed in both Schwann and neuron-type differentiating cells. PMID: 19393748

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, P-body.
  • 蛋白家族：
    Argonaute family, Ago subfamily
  • 數據庫鏈接：

    HGNC: 18421

    OMIM: 607355

    KEGG: hsa:192669

    STRING: 9606.ENSP00000362287

    UniGene: Hs.657659



主站蜘蛛池模板： 45分钟免费真人视频| 国产v在线最新观看视频| 亚洲免费观看视频| 亚洲中文字幕无码中文字在线| 韩国精品一区二区三区四区 | 97无码免费人妻超级碰碰碰碰| 午夜色大片在线观看| 啦啦啦www播放日本观看 | 特级a欧美做爰片三人交| 韩国精品久久久久久无码| 亚洲人成网亚洲欧洲无码| 老太婆性杂交视频| 国产成人综合久久精品推最新| 丰满少妇人妻hd高清大乳在线| 国产精品又黄又爽又色无遮挡 | 欧美人与动牲交zooz男人| 99r在线精品视频在线播放| 久久人妻夜夜做天天爽| 综合人妻久久一区二区精品| 国产 精品 自在 线免费| 97se狼狼狼狼狼亚洲网| 久久久无码精品亚洲日韩按摩| 99久久婷婷国产综合精品电影| 久久九九精品国产综合喷水| 亚洲国内成人精品网| 国产人与zoxxxx另类| 精品人妻伦九区久久aaa片69| 99国产成人精品视频| 日韩少妇人妻vs中文字幕| 久久丫精品国产| 天无日天天射天天视| 波多野结衣一区二区免费视频 | 亚洲一区精品无码色成人| 亚洲国产av美女网站| 久久精品中文无码资源站| 狠狠做久久深爱婷婷| 国产精品原创av片国产日韩| 国产久热精品无码激情| 十八禁无码精品a∨在线观看| 欧美人伦禁忌dvd放荡欲情| 97人妻人人揉人人躁人人|