在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Protein-arginine deiminase type-1 (PADI1)

  • 中文名稱:
    Recombinant Human Protein-arginine deiminase type-1 (PADI1)
  • 貨號:
    CSB-EP891543HUc7
  • 規格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
    PADI1
  • Uniprot No.:
  • 別名:
    Peptidylarginine deiminase I;Protein-arginine deiminase type I
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    E.coli
  • 分子量:
    81.6 kDa
  • 表達區域:
    1-663aa
  • 氨基酸序列
    MAPKRVVQLSLKMPTHAVCVVGVEAHVDIHSDVPKGANSFRVSGSSGVEVFMVYNRTRVKEPIGKARWPLDTDADMVVSVGTASKELKDFKVRVSYFGEQEDQALGRSVLYLTGVDISLEVDTGRTGKVKRSQGDKKTWRWGPEGYGAILLVNCDRDNHRSAEPDLTHSWLMSLADLQDMSPMLLSCNGPDKLFDSHKLVLNVPFSDSKRVRVFCARGGNSLSDYKQVLGPQCLSYEVERQPGEQEIKFYVEGLTFPDADFLGLVSLSVSLVDPGTLPEVTLFTDTVGFRMAPWIMTPNTQPPEELYVCRVMDTHGSNEKFLEDMSYLTLKANCKLTICPQVENRNDRWIQDEMEFGYIEAPHKSFPVVFDSPRNRGLKDFPYKRILGPDFGYVTREIPLPGPSSLDSFGNLDVSPPVTVGGTEYPLGRILIGSSFPKSGGRQMARAVRNFLKAQQVQAPVELYSDWLSVGHVDEFLTFVPTSDQKGFRLLLASPSACLKLFQEKKEEGYGEAAQFDGLKHQAKRSINEMLADRHLQRDNLHAQKCIDWNRNVLKRELGLAESDIVDIPQLFFLKNFYAEAFFPDMVNMVVLGKYLGIPKPYGPIINGRCCLEEKVQSLLEPLGLHCIFIDDYLSYHELQGEIHCGTNVRRKPFPFKWWNMVP
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Catalyzes the deimination of arginine residues of proteins.
  • 基因功能參考文獻:
    1. Authors showed that PAD1 interacts with and citrullinates MEK1 thereby disrupting MEK1-catalyzed ERK1/2 phosphorylation, thus leading to the MMP2 overexpression. PMID: 28844713
    2. Identify acefylline as an activator of peptidylarginine deiminase 1 and 3 in the epidermis, resulting in filaggrin deimination. PMID: 26616205
    3. NF-kappaB-mediated signaling pathway is involved in PADI1 regulation in human epidermal keratinocytes PMID: 20596086
    4. cloning, gene organization, and expression analysis PMID: 12416996
    5. peptidylarginine deiminase types 1 and 3 loci map to chromosomal band 1p36.13 PMID: 15150696
    6. PAD1 and 3 are able to modify filaggrin PMID: 15675958
    7. PAD1 is co-located with filaggrin within the filamentous matrix of the deeper corneocytes where the protein is deiminated. PMID: 16091842
    8. MZF1 and Sp1/Sp3 binding to the promoter region drive the PADI1 expression in keratinocytes PMID: 17851584
    9. The expressoin of COL1A1-PADI1 genes were particularly effective in distinguishing OCSS from normal tissue. PMID: 18669583
    10. peptidylarginine deiminase citrullinates the chemokine CXCL8, and thus may dampen neutrophil extravasation during acute or chronic inflammation PMID: 18710930

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Protein arginine deiminase family
  • 組織特異性:
    Detected in epidermal keratinocytes (at protein level). Epidermis, prostate, testis, placenta, spleen and thymus.
  • 數據庫鏈接:

    HGNC: 18367

    OMIM: 607934

    KEGG: hsa:29943

    STRING: 9606.ENSP00000364620

    UniGene: Hs.412941



主站蜘蛛池模板: 无码中文字幕日韩专区视频| 国产啪精品视频网站免| 无码三级在线看中文字幕完整版 | 成人午夜视频精品一区| 青草影院内射中出高潮| 亚洲亚洲人成综合丝袜图片| 337p日本欧洲亚洲大胆精品| 无码专区人妻系列日韩精品少妇| 超碰香蕉人人网99精品| 国产xxx视频在线观看软件| 少妇高潮喷水惨叫久久久久电影| 亚洲另类无码一区二区三区| 久久综合九色综合欧美狠狠| 亚洲国产成人精品无码一区二区| 亚洲成av人最新无码| 任你躁x7x7x7x7在线观看| 亚洲另类无码专区国内精品 | 精品香蕉一区二区三区| 国产成人av一区二区三区在线 | 国模无码一区二区三区不卡| 国产成人国产在线观看| 欧美乱大交xxxxx潮喷l头像 | 中文天堂在线www| 无码吃奶揉捏奶头高潮视频| 久久亚洲精品无码av红樱桃| 亚洲国产av美女网站| 国产精品久久久久影院| 亚洲aⅴ在线无码播放毛片一线天 吃奶摸下高潮60分钟免费视频 | 亚洲精品一区二区国产精华液| 成人午夜福利视频| 亚洲色婷婷久久精品av蜜桃| 四虎国产精品成人免费久久| 国产精品人妻熟女男人的天堂| 色偷偷色噜噜狠狠成人免费视频| 国产成人麻豆精品午夜福利在线| 国精品99久9在线 | 免费| 天天躁日日躁狠狠躁性色avq| 日日噜噜夜夜狠狠视频| 国产尤物人成免费观看| 国产精品无码一区二区在线观一| 脱岳裙子从后面挺进去在线观看|