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  4. PADI1 Antibody, Biotin conjugated

PADI1 Antibody, Biotin conjugated

  • 中文名稱(chēng)：
    PADI1兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA891543LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：
    Rabbit anti-Homo sapiens (Human) PADI1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PADI1
  • 別名：
    HPAD10 antibody; Padi1 antibody; PADI1_HUMAN antibody; PDI antibody; PDI1 antibody; Peptidylarginine deiminase I antibody; protein arginine deiminase type I antibody; Protein-arginine deiminase type I antibody; Protein-arginine deiminase type-1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Protein-arginine deiminase type-1 protein (1-663AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類(lèi)型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Catalyzes the deimination of arginine residues of proteins.
  • 基因功能參考文獻(xiàn)：
    1. Authors showed that PAD1 interacts with and citrullinates MEK1 thereby disrupting MEK1-catalyzed ERK1/2 phosphorylation, thus leading to the MMP2 overexpression. PMID: 28844713
    2. Identify acefylline as an activator of peptidylarginine deiminase 1 and 3 in the epidermis, resulting in filaggrin deimination. PMID: 26616205
    3. NF-kappaB-mediated signaling pathway is involved in PADI1 regulation in human epidermal keratinocytes PMID: 20596086
    4. cloning, gene organization, and expression analysis PMID: 12416996
    5. peptidylarginine deiminase types 1 and 3 loci map to chromosomal band 1p36.13 PMID: 15150696
    6. PAD1 and 3 are able to modify filaggrin PMID: 15675958
    7. PAD1 is co-located with filaggrin within the filamentous matrix of the deeper corneocytes where the protein is deiminated. PMID: 16091842
    8. MZF1 and Sp1/Sp3 binding to the promoter region drive the PADI1 expression in keratinocytes PMID: 17851584
    9. The expressoin of COL1A1-PADI1 genes were particularly effective in distinguishing OCSS from normal tissue. PMID: 18669583
    10. peptidylarginine deiminase citrullinates the chemokine CXCL8, and thus may dampen neutrophil extravasation during acute or chronic inflammation PMID: 18710930

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  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    Protein arginine deiminase family
  • 組織特異性：
    Detected in epidermal keratinocytes (at protein level). Epidermis, prostate, testis, placenta, spleen and thymus.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 18367

    OMIM: 607934

    KEGG: hsa:29943

    STRING: 9606.ENSP00000364620

    UniGene: Hs.412941



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