在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Protein-arginine deiminase type-1 (PADI1)

  • 中文名稱:
    人PADI1重組蛋白
  • 貨號:
    CSB-YP891543HU
  • 規格:
    ¥1500
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    PADI1
  • Uniprot No.:
  • 別名:
    HPAD10; Padi1; PADI1_HUMAN; PDI; PDI1; Peptidylarginine deiminase I; protein arginine deiminase type I; Protein-arginine deiminase type I; Protein-arginine deiminase type-1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    Yeast
  • 分子量:
    76.7kDa
  • 表達區域:
    1-663aa
  • 氨基酸序列
    MAPKRVVQLSLKMPTHAVCVVGVEAHVDIHSDVPKGANSFRVSGSSGVEVFMVYNRTRVKEPIGKARWPLDTDADMVVSVGTASKELKDFKVRVSYFGEQEDQALGRSVLYLTGVDISLEVDTGRTGKVKRSQGDKKTWRWGPEGYGAILLVNCDRDNHRSAEPDLTHSWLMSLADLQDMSPMLLSCNGPDKLFDSHKLVLNVPFSDSKRVRVFCARGGNSLSDYKQVLGPQCLSYEVERQPGEQEIKFYVEGLTFPDADFLGLVSLSVSLVDPGTLPEVTLFTDTVGFRMAPWIMTPNTQPPEELYVCRVMDTHGSNEKFLEDMSYLTLKANCKLTICPQVENRNDRWIQDEMEFGYIEAPHKSFPVVFDSPRNRGLKDFPYKRILGPDFGYVTREIPLPGPSSLDSFGNLDVSPPVTVGGTEYPLGRILIGSSFPKSGGRQMARAVRNFLKAQQVQAPVELYSDWLSVGHVDEFLTFVPTSDQKGFRLLLASPSACLKLFQEKKEEGYGEAAQFDGLKHQAKRSINEMLADRHLQRDNLHAQKCIDWNRNVLKRELGLAESDIVDIPQLFFLKNFYAEAFFPDMVNMVVLGKYLGIPKPYGPIINGRCCLEEKVQSLLEPLGLHCIFIDDYLSYHELQGEIHCGTNVRRKPFPFKWWNMVP
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Catalyzes the deimination of arginine residues of proteins.
  • 基因功能參考文獻:
    1. Authors showed that PAD1 interacts with and citrullinates MEK1 thereby disrupting MEK1-catalyzed ERK1/2 phosphorylation, thus leading to the MMP2 overexpression. PMID: 28844713
    2. Identify acefylline as an activator of peptidylarginine deiminase 1 and 3 in the epidermis, resulting in filaggrin deimination. PMID: 26616205
    3. NF-kappaB-mediated signaling pathway is involved in PADI1 regulation in human epidermal keratinocytes PMID: 20596086
    4. cloning, gene organization, and expression analysis PMID: 12416996
    5. peptidylarginine deiminase types 1 and 3 loci map to chromosomal band 1p36.13 PMID: 15150696
    6. PAD1 and 3 are able to modify filaggrin PMID: 15675958
    7. PAD1 is co-located with filaggrin within the filamentous matrix of the deeper corneocytes where the protein is deiminated. PMID: 16091842
    8. MZF1 and Sp1/Sp3 binding to the promoter region drive the PADI1 expression in keratinocytes PMID: 17851584
    9. The expressoin of COL1A1-PADI1 genes were particularly effective in distinguishing OCSS from normal tissue. PMID: 18669583
    10. peptidylarginine deiminase citrullinates the chemokine CXCL8, and thus may dampen neutrophil extravasation during acute or chronic inflammation PMID: 18710930

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Protein arginine deiminase family
  • 組織特異性:
    Detected in epidermal keratinocytes (at protein level). Epidermis, prostate, testis, placenta, spleen and thymus.
  • 數據庫鏈接:

    HGNC: 18367

    OMIM: 607934

    KEGG: hsa:29943

    STRING: 9606.ENSP00000364620

    UniGene: Hs.412941



主站蜘蛛池模板: 中文字幕av一区乱码| 日本无遮挡边做边爱边摸| 性色av无码一区二区三区人妻| 忍不住的亲子中文字幕| 蜜臀av色欲a片无码精品一区 | 国产成人无码a区精油按摩| 青娱乐极品视觉盛宴国产视频| 欧美尺码专线欧洲b1b1| 69成人免费视频无码专区| 少妇被又大又粗下爽a片| 西西人体做爰大胆性自慰| 国产熟妇乱xxxxx大屁股网| 精品久久国产字幕高潮| 好男人社区www在线官网| 国产在线无码制服丝袜无码| 大陆国产乱人伦| 亚洲aⅴ综合av国产八av| 亚洲成a v人片在线观看| 国产9 9在线 | 中文| 无码h肉在线观看免费一区| 香蕉97超级碰碰碰视频| 99热在线精品国产观看| 99久久国产综合精品麻豆| 香港三级韩国三级日本三级| 亚洲精品无码久久毛片| 午夜性刺激在线视频免费| 亚洲最大成人av在线天堂网| 亚洲精品国产一区二区精华液| 国产又爽又黄无码无遮挡在线观看| 天堂8а√中文在线官网| 国产乱了伦视频大全亚琴影院| 国产精品视频| 亚洲一卡一卡二新区无人区| 色悠久久久久综合先锋影音下载 | 无码一区二区三区在线| 一本一道波多野结衣av黑人| 亚洲欧美韩国综合色| 人妻少妇无码中文幕久久| 无码一区二区三区视频| 亚洲色欲久久久久综合网| 免费看撕开奶罩揉吮奶头视频|