在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Proteasome subunit beta type-1 (PSMB1)

  • 中文名稱:
    人PSMB1重組蛋白
  • 貨號:
    CSB-YP018876HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人PSMB1重組蛋白
  • 貨號:
    CSB-EP018876HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人PSMB1重組蛋白
  • 貨號:
    CSB-EP018876HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人PSMB1重組蛋白
  • 貨號:
    CSB-BP018876HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人PSMB1重組蛋白
  • 貨號:
    CSB-MP018876HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    PSMB1
  • Uniprot No.:
  • 別名:
    FLJ25321; HC5; KIAA1838; Macropain subunit C5; Multicatalytic endopeptidase complex subunit C5; Proteasome (prosome macropain) subunit beta type 1; Proteasome beta 1 subunit; Proteasome component C5; Proteasome gamma chain; Proteasome subunit beta type 1; Proteasome subunit beta type-1; Proteasome subunit HC5; PSB1_HUMAN; PSC5; PSMB 1; PSMB1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    29-241
  • 氨基酸序列
    RF SPYVFNGGTI LAIAGEDFAI VASDTRLSEG FSIHTRDSPK CYKLTDKTVI GCSGFHGDCL TLTKIIEARL KMYKHSNNKA MTTGAIAAML STILYSRRFF PYYVYNIIGG LDEEGKGAVY SFDPVGSYQR DSFKAGGSAS AMLQPLLDNQ VGFKNMQNVE HVPLSLDRAM RLVKDVFISA AERDVYTGDA LRICIVTKEG IREETVSLRK D
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
  • 基因功能參考文獻:
    1. In vitro analyses demonstrated significantly reduced protease activity in proteasomes of individuals with G/G genotype compared with that of C/C carriers, despite that PSMB1 expression and proteasome assembly remained unaltered. PMID: 28733196
    2. The proteasome beta1 subunit plays a novel role in tumorigenesis by degrading p27Kip1. PMID: 23725357
    3. The mutated form of PSMB1 displayed increased nuclear translocation, resulting in activation of transcription in adipocytes. PMID: 23924720
    4. The proteasome was found to be activated in primary sjogren syndrome, with upregulation of gene expression of catalytic proteasome subunits. PMID: 23504381
    5. Follicular lymphoma patients with PSMB1 P11A (G allele) and low CD68 expression have significantly longer progression free survival with bortezomib-rituximab versus rituximab. PMID: 23549871
    6. PSMB1 is part of the transcriptional machinery required for gastrin stimulated expression of PAI-2 and Reg1. PMID: 23544109
    7. Expression of 26S proteasome beta(1)-subunit in NB4 cells increased after incubation with As(2)O(3). PMID: 19549367
    8. data defined a unique motif of BCL-3 that is needed for its recruitment to the proteasome and identified PSMB1 as a key protein required for the proteasome-mediated degradation of a nuclear and oncogenic IkappaB protein. PMID: 20558726

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    Peptidase T1B family
  • 數據庫鏈接:

    HGNC: 9537

    OMIM: 602017

    KEGG: hsa:5689

    STRING: 9606.ENSP00000262193

    UniGene: Hs.352768



主站蜘蛛池模板: 新香蕉少妇视频网站| 和岳每晚弄的高潮嗷嗷叫视频| 内射夜晚在线观看| 色妺妺免费影院| 国产高清精品软件丝瓜软件| 成人无码亚洲精品无码| 国产成人无码一区二区在线观看| 国模少妇一区二区三区| 欧美黑人xxxx又粗又长 | 午夜高清国产拍精品| 狠狠色婷婷久久综合频道毛片| 国产午夜精品无码| 新版天堂资源中文www连接| 亚洲午夜久久久无码精品网红a片| 国产人妻精品午夜福利免费| av香港经典三级级 在线| 日本护士毛茸茸xx| 婷婷综合缴情亚洲| 国产美女在线精品免费观看网址| 国产精品美女www爽爽爽视频| 欧洲 亚洲 国产图片综合| 久久不见久久见免费影院国语| 日韩av无码一区二区三区不卡| 中文字幕日韩精品无码内射| 一本天堂v无码亚洲道久久| 噜噜久久噜噜久久鬼88| 免费人妻av无码专区| 中文午夜乱理片无码| 蜜臀少妇人妻在线| 亚洲中文字幕无码中文字| 日韩人妻无码一区二区三区综合部| 青青青国产在线观看免费| 国产高清在线精品一区免费| 一个人看的www免费视频在线观看| 日日噜噜夜夜狠狠久久无码区| 久久高清超碰av热热久久| 激情综合婷婷色五月蜜桃| 国产情侣一区二区三区| 国产v精品成人免费视频| 五月天激情婷婷婷久久| 无码精品人妻一区二区三区免费看 |