在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PSMB1 Antibody

PSMB1 Antibody

  • 中文名稱：
    PSMB1兔多克隆抗體
  • 貨號：
    CSB-PA018876GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    PSMB1
  • 別名：
    FLJ25321 antibody; HC5 antibody; KIAA1838 antibody; Macropain subunit C5 antibody; Multicatalytic endopeptidase complex subunit C5 antibody; Proteasome (prosome macropain) subunit beta type 1 antibody; Proteasome beta 1 subunit antibody; Proteasome component C5 antibody; Proteasome gamma chain antibody; Proteasome subunit beta type 1 antibody; Proteasome subunit beta type-1 antibody; Proteasome subunit HC5 antibody; PSB1_HUMAN antibody; PSC5 antibody; PSMB 1 antibody; PSMB1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human PSMB1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC,IF
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
  • 基因功能參考文獻：
    1. In vitro analyses demonstrated significantly reduced protease activity in proteasomes of individuals with G/G genotype compared with that of C/C carriers, despite that PSMB1 expression and proteasome assembly remained unaltered. PMID: 28733196
    2. The proteasome beta1 subunit plays a novel role in tumorigenesis by degrading p27Kip1. PMID: 23725357
    3. The mutated form of PSMB1 displayed increased nuclear translocation, resulting in activation of transcription in adipocytes. PMID: 23924720
    4. The proteasome was found to be activated in primary sjogren syndrome, with upregulation of gene expression of catalytic proteasome subunits. PMID: 23504381
    5. Follicular lymphoma patients with PSMB1 P11A (G allele) and low CD68 expression have significantly longer progression free survival with bortezomib-rituximab versus rituximab. PMID: 23549871
    6. PSMB1 is part of the transcriptional machinery required for gastrin stimulated expression of PAI-2 and Reg1. PMID: 23544109
    7. Expression of 26S proteasome beta(1)-subunit in NB4 cells increased after incubation with As(2)O(3). PMID: 19549367
    8. data defined a unique motif of BCL-3 that is needed for its recruitment to the proteasome and identified PSMB1 as a key protein required for the proteasome-mediated degradation of a nuclear and oncogenic IkappaB protein. PMID: 20558726

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Peptidase T1B family
  • 數據庫鏈接：

    HGNC: 9537

    OMIM: 602017

    KEGG: hsa:5689

    STRING: 9606.ENSP00000262193

    UniGene: Hs.352768



主站蜘蛛池模板： 久久精品噜噜噜成人av| 又黄又爽又色的免费网站| 精品人妻伦一二三区久久aaa片| 性饥渴的农村熟妇| 日韩成人无码中文字幕| 亚洲精品福利一区二区三区蜜桃| 少妇大叫太大太爽受不了在线观看 | 亚洲欧洲自拍拍偷综合| 丰满多毛少妇做爰视频爽爽和| 成人做受黄大片| 正在播放重口老熟女露脸| 成 人 网 站94免费观看| 欧美色欧美亚洲高清在线视频| 亚洲成在人线视av| 国产人成网线在线播放va| 天堂网www中文在线| 丝袜老师高潮呻吟高潮| 内射女校花一区二区三区| 日韩av无码精品人妻系列| av网站免费线看精品| 国产三级视频在线播放线观看| 久久综合九色综合97欧美| 欧美人与动牲交zooz乌克兰| 国产综合精品久久丫| 国语自产视频在线| 扒开女人内裤猛进猛出免费视频| 免费看男女做爰爽爽视频| 精品久久久久久777米琪桃花 | 成人区人妻精品一区二区不卡网站| 三上悠亚人妻中文字幕在线| 2020年最新国产精品正在播放| 自拍偷自拍亚洲精品第1页| 狠狠88综合久久久久综合网| 又色又爽又高潮免费观看| 亚洲精品无码专区在线| 亚洲中文字幕无码永久在线| 性荡视频播放在线视频| 鲁一鲁一鲁一鲁一曰综合网| 亚洲熟女乱色一区二区三区| 亚洲深深色噜噜狠狠爱网站| 99久久精品国产一区二区 |