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  4. PSMB1 Antibody

PSMB1 Antibody

  • 中文名稱：
    PSMB1兔多克隆抗體
  • 貨號：
    CSB-PA01395A0Rb
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: Proteasome subunit beta 1 antibody at 2μg/ml
      Lane 1: EC109 whole cell lysate
      Lane 2: 293T whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/15000 dilution
      Predicted band size: 27 kDa
      Observed band size: 27 kDa
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PSMB1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PSMB1
  • 別名：
    FLJ25321 antibody; HC5 antibody; KIAA1838 antibody; Macropain subunit C5 antibody; Multicatalytic endopeptidase complex subunit C5 antibody; Proteasome (prosome macropain) subunit beta type 1 antibody; Proteasome beta 1 subunit antibody; Proteasome component C5 antibody; Proteasome gamma chain antibody; Proteasome subunit beta type 1 antibody; Proteasome subunit beta type-1 antibody; Proteasome subunit HC5 antibody; PSB1_HUMAN antibody; PSC5 antibody; PSMB 1 antibody; PSMB1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Proteasome subunit beta type-1 protein (29-241AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，PSMB1 Antibody (CSB-PA01395A0Rb)，的標記方式是Non-conjugated。對于PSMB1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA01395B0Rb PSMB1 Antibody, HRP conjugated ELISA
    FITC CSB-PA01395C0Rb PSMB1 Antibody, FITC conjugated
    Biotin CSB-PA01395D0Rb PSMB1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
  • 基因功能參考文獻：
    1. In vitro analyses demonstrated significantly reduced protease activity in proteasomes of individuals with G/G genotype compared with that of C/C carriers, despite that PSMB1 expression and proteasome assembly remained unaltered. PMID: 28733196
    2. The proteasome beta1 subunit plays a novel role in tumorigenesis by degrading p27Kip1. PMID: 23725357
    3. The mutated form of PSMB1 displayed increased nuclear translocation, resulting in activation of transcription in adipocytes. PMID: 23924720
    4. The proteasome was found to be activated in primary sjogren syndrome, with upregulation of gene expression of catalytic proteasome subunits. PMID: 23504381
    5. Follicular lymphoma patients with PSMB1 P11A (G allele) and low CD68 expression have significantly longer progression free survival with bortezomib-rituximab versus rituximab. PMID: 23549871
    6. PSMB1 is part of the transcriptional machinery required for gastrin stimulated expression of PAI-2 and Reg1. PMID: 23544109
    7. Expression of 26S proteasome beta(1)-subunit in NB4 cells increased after incubation with As(2)O(3). PMID: 19549367
    8. data defined a unique motif of BCL-3 that is needed for its recruitment to the proteasome and identified PSMB1 as a key protein required for the proteasome-mediated degradation of a nuclear and oncogenic IkappaB protein. PMID: 20558726

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  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Peptidase T1B family
  • 數據庫鏈接：

    HGNC: 9537

    OMIM: 602017

    KEGG: hsa:5689

    STRING: 9606.ENSP00000262193

    UniGene: Hs.352768



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