在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Proteasome maturation protein (POMP)

  • 中文名稱:
    人POMP重組蛋白
  • 貨號(hào):
    CSB-YP018365HU
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人POMP重組蛋白
  • 貨號(hào):
    CSB-EP018365HU
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人POMP重組蛋白
  • 貨號(hào):
    CSB-EP018365HU-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人POMP重組蛋白
  • 貨號(hào):
    CSB-BP018365HU
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人POMP重組蛋白
  • 貨號(hào):
    CSB-MP018365HU
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    POMP
  • Uniprot No.:
  • 別名:
    2510048O06Rik; C13orf12; Chromosome 13 open reading frame 12 ; HSPC 014; HSPC036 protein ; hUMP 1; hUMP1; PNAS 110; PNAS110; Pomp; POMP_HUMAN; Proteasome maturation protein; Proteassemblin; Protein UMP1 homolog; UMP 1; UMP1; UMP1; yeast; homolog of; Voltage gated K channel beta subunit 4.1 ; Voltage-gated K channel beta subunit 4.1; voltage-gated potassium channel beta subunit 4.1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達(dá)區(qū)域:
    1-141
  • 氨基酸序列
    MNARGLGSEL KDSIPVTELS ASGPFESHDL LRKGFSCVKN ELLPSHPLEL SEKNFQLNQD KMNFSTLRNI QGLFAPLKLQ MEFKAVQQVQ RLPFLSSSNL SLDVLRGNDE TIGFEDILND PSQSEVMGEP HLMVEYKLGL L
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the association of 20S preproteasome with the endoplasmic reticulum.
  • 基因功能參考文獻(xiàn):
    1. POMP-related autoinflammation and immune dysregulation disease (PRAID) discovered in two unrelated individuals with a unique constellation of early-onset combined immunodeficiency, inflammatory neutrophilic dermatosis, and autoimmunity, is reported. PMID: 29805043
    2. POMP is overexpressed and participates in the increase of proteasome assembly and activity in psoriatic skin. PMID: 28728908
    3. MCM3AP and POMP Mutations Cause a DNA-Repair and DNA-Damage-Signaling Defect in an Immunodeficient Child PMID: 26615982
    4. studies validate a role for the NRF2/POMP axis in bortezomib resistance and identify NRF2 and POMP as potentially attractive targets for chemosensitization to this proteasome inhibitor PMID: 26483548
    5. microRNA-101 (miR-101) targets the proteasome maturation protein POMP, leading to impaired proteasome assembly and activity, and resulting in accumulation of p53 and cyclin-dependent kinase inhibitors, cell cycle arrest, and apoptosis. PMID: 26145175
    6. Single-nucleotide polymorphisms in POMP gene is associated with breast cancer risk after menopausal hormone replacement therapy. PMID: 24080446
    7. KLICK is caused by reduced levels of POMP, leading to proteasome insufficiency in differentiating keratinocytes PMID: 22235297
    8. A single-nucleotide deletion in the POMP 5' UTR causes a transcriptional switch and altered epidermal proteasome distribution in KLICK genodermatosis. PMID: 20226437
    9. POMP/proteassemblin/hUmp1 may be tetramerised and is localized to the cytoplasm and the nucleus PMID: 16624403
    10. Data show that POMP facilitates the main steps in 20S core complex formation at the ER to coordinate the assembly process and to provide cells with freshly formed proteasomes at their site of function. PMID: 17948026

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Keratosis linearis with ichthyosis congenita and sclerosing keratoderma (KLICK)
  • 亞細(xì)胞定位:
    Cytoplasm, cytosol. Nucleus. Microsome membrane.
  • 蛋白家族:
    POMP/UMP1 family
  • 組織特異性:
    Strongly expressed from the basal layer to the granular layer of healthy epidermis, whereas in KLICK patients there is a gradual decrease of expression toward the granular layer.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 20330

    OMIM: 601952

    KEGG: hsa:51371

    STRING: 9606.ENSP00000370222

    UniGene: Hs.268742



主站蜘蛛池模板: 久久久久亚洲精品成人网| 全国最大成人网| 中文字幕人妻熟女人妻| 日本丰满熟妇videossex8k| 九九热在线视频观看这里只有精品 | 日韩 高清 无码 人妻| 国产孩cao大人xxxx| 人妻系列无码一区二区三区| 国产一国产aa毛片| 妺妺窝人体色www婷婷| 曰本女人与公拘交酡| 亚洲人成精品久久久久桥| 青青青国产在线观看免费| 国产精品久久久久久久伊一| 国产精品无码一区二区三区免费 | 中文字幕一区二区三区乱码| 国产精品久久久久9999爆乳 | 无码av中文一区二区三区| 麻豆果冻传媒2021精品传媒一区下载| 无码人妻丰满熟妇奶水区码 | 欧美日本亚洲韩国一区| 骚动漫十八禁在线观看| 一本色道久久99一综合| 国产乱子伦精品视频| 真人做作爱视频| 亚洲a∨精品永久无码| 中文无码日韩欧免费视频| 成人性生交大片免费看中文| 成人区人妻精品一区二区不卡视频| 国产精品被窝福利一区| 伦理片无码电影在线看| 欧美欧洲成本大片免费| 搡老岳熟女国产熟妇| 精品爆乳一区二区三区无码av| 亚洲综合日韩久久成人av| 中文字幕大看蕉在线观看| 国产精品久久无码一区| 国产一区二区三区四区五区加勒比| 精品无人区码一码二码三码区别| 好爽...又高潮了毛片| 国产精品久久久久无码av|