在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. POMP Antibody

POMP Antibody

  • 中文名稱：
    POMP兔多克隆抗體
  • 貨號：
    CSB-PA018365LA01HU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA018365LA01HU diluted at 1:400 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of HepG2 cells with CSB-PA018365LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) POMP Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    POMP
  • 別名：
    2510048O06Rik antibody; C13orf12 antibody; Chromosome 13 open reading frame 12 antibody; HSPC 014 antibody; HSPC036 protein antibody; hUMP 1 antibody; hUMP1 antibody; PNAS 110 antibody; PNAS110 antibody; Pomp antibody; POMP_HUMAN antibody; Proteasome maturation protein antibody; Proteassemblin antibody; Protein UMP1 homolog antibody; UMP 1 antibody; UMP1 antibody; UMP1; yeast; homolog of antibody; Voltage gated K channel beta subunit 4.1 antibody; Voltage-gated K channel beta subunit 4.1 antibody; voltage-gated potassium channel beta subunit 4.1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Proteasome maturation protein (1-141AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，POMP Antibody (CSB-PA018365LA01HU)，的標記方式是Non-conjugated。對于POMP Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA018365LB01HU POMP Antibody, HRP conjugated ELISA
    FITC CSB-PA018365LC01HU POMP Antibody, FITC conjugated
    Biotin CSB-PA018365LD01HU POMP Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the association of 20S preproteasome with the endoplasmic reticulum.
  • 基因功能參考文獻：
    1. POMP-related autoinflammation and immune dysregulation disease (PRAID) discovered in two unrelated individuals with a unique constellation of early-onset combined immunodeficiency, inflammatory neutrophilic dermatosis, and autoimmunity, is reported. PMID: 29805043
    2. POMP is overexpressed and participates in the increase of proteasome assembly and activity in psoriatic skin. PMID: 28728908
    3. MCM3AP and POMP Mutations Cause a DNA-Repair and DNA-Damage-Signaling Defect in an Immunodeficient Child PMID: 26615982
    4. studies validate a role for the NRF2/POMP axis in bortezomib resistance and identify NRF2 and POMP as potentially attractive targets for chemosensitization to this proteasome inhibitor PMID: 26483548
    5. microRNA-101 (miR-101) targets the proteasome maturation protein POMP, leading to impaired proteasome assembly and activity, and resulting in accumulation of p53 and cyclin-dependent kinase inhibitors, cell cycle arrest, and apoptosis. PMID: 26145175
    6. Single-nucleotide polymorphisms in POMP gene is associated with breast cancer risk after menopausal hormone replacement therapy. PMID: 24080446
    7. KLICK is caused by reduced levels of POMP, leading to proteasome insufficiency in differentiating keratinocytes PMID: 22235297
    8. A single-nucleotide deletion in the POMP 5' UTR causes a transcriptional switch and altered epidermal proteasome distribution in KLICK genodermatosis. PMID: 20226437
    9. POMP/proteassemblin/hUmp1 may be tetramerised and is localized to the cytoplasm and the nucleus PMID: 16624403
    10. Data show that POMP facilitates the main steps in 20S core complex formation at the ER to coordinate the assembly process and to provide cells with freshly formed proteasomes at their site of function. PMID: 17948026

    顯示更多

    收起更多

  • 相關疾病：
    Keratosis linearis with ichthyosis congenita and sclerosing keratoderma (KLICK)
  • 亞細胞定位：
    Cytoplasm, cytosol. Nucleus. Microsome membrane.
  • 蛋白家族：
    POMP/UMP1 family
  • 組織特異性：
    Strongly expressed from the basal layer to the granular layer of healthy epidermis, whereas in KLICK patients there is a gradual decrease of expression toward the granular layer.
  • 數據庫鏈接：

    HGNC: 20330

    OMIM: 601952

    KEGG: hsa:51371

    STRING: 9606.ENSP00000370222

    UniGene: Hs.268742



主站蜘蛛池模板： 国产精品无打码在线播放| 亚洲国产成人久久综合一区| 激情综合五月| 国产日产人妻精品精品| 日本肉体xxxx裸交| 日韩人妻熟女中文字幕aⅴ春菜| 真实国产精品视频400部| 国产又色又爽又黄的视频在线| 欧美日韩中文国产一区发布 | 在线观看无码av网址| 欧美性xxxxx极品老少| 琪琪电影午夜理论片八戒八戒| 亚洲国产成人精品福利| 久久精品国产久精国产爱| 国产东北肥熟老胖女| 粗大猛烈进出高潮视频免费看| 亚洲人av在线无码影院观看| 日本一上一下爱爱免费| 韩国v欧美v亚洲v日本v| 97免费人妻无码视频| 亚洲熟妇无码av另类vr影视| 奇米777四色成人影视| 一本久道中文无码字幕av| 日韩欧美高清dvd碟片| 人人模人人爽人人喊久久| 国产成人精品999视频| 中文字幕在线精品视频| 亚洲人妻av伦理| 99久久久无码国产精品试看| 男人和女人高潮做爰视频| 久久97精品久久久久久久不卡| 狠狠色婷婷久久一区二区三区| 色综合色欲色综合色综合色综合r| 色老头精品午夜福利视频| 在线看片福利无码网址| 国产精品久久久久久影视| 亚洲美女高清aⅴ视频免费| 久久精品无码av| 中文字幕日本人妻久久久免费| 午夜电影网va内射| 亚洲国产精品ⅴa在线播放|