在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

POMP Antibody, Biotin conjugated

  • 中文名稱:
    POMP兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA018365LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) POMP Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    POMP
  • 別名:
    2510048O06Rik antibody; C13orf12 antibody; Chromosome 13 open reading frame 12 antibody; HSPC 014 antibody; HSPC036 protein antibody; hUMP 1 antibody; hUMP1 antibody; PNAS 110 antibody; PNAS110 antibody; Pomp antibody; POMP_HUMAN antibody; Proteasome maturation protein antibody; Proteassemblin antibody; Protein UMP1 homolog antibody; UMP 1 antibody; UMP1 antibody; UMP1; yeast; homolog of antibody; Voltage gated K channel beta subunit 4.1 antibody; Voltage-gated K channel beta subunit 4.1 antibody; voltage-gated potassium channel beta subunit 4.1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Proteasome maturation protein (1-141AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the association of 20S preproteasome with the endoplasmic reticulum.
  • 基因功能參考文獻:
    1. POMP-related autoinflammation and immune dysregulation disease (PRAID) discovered in two unrelated individuals with a unique constellation of early-onset combined immunodeficiency, inflammatory neutrophilic dermatosis, and autoimmunity, is reported. PMID: 29805043
    2. POMP is overexpressed and participates in the increase of proteasome assembly and activity in psoriatic skin. PMID: 28728908
    3. MCM3AP and POMP Mutations Cause a DNA-Repair and DNA-Damage-Signaling Defect in an Immunodeficient Child PMID: 26615982
    4. studies validate a role for the NRF2/POMP axis in bortezomib resistance and identify NRF2 and POMP as potentially attractive targets for chemosensitization to this proteasome inhibitor PMID: 26483548
    5. microRNA-101 (miR-101) targets the proteasome maturation protein POMP, leading to impaired proteasome assembly and activity, and resulting in accumulation of p53 and cyclin-dependent kinase inhibitors, cell cycle arrest, and apoptosis. PMID: 26145175
    6. Single-nucleotide polymorphisms in POMP gene is associated with breast cancer risk after menopausal hormone replacement therapy. PMID: 24080446
    7. KLICK is caused by reduced levels of POMP, leading to proteasome insufficiency in differentiating keratinocytes PMID: 22235297
    8. A single-nucleotide deletion in the POMP 5' UTR causes a transcriptional switch and altered epidermal proteasome distribution in KLICK genodermatosis. PMID: 20226437
    9. POMP/proteassemblin/hUmp1 may be tetramerised and is localized to the cytoplasm and the nucleus PMID: 16624403
    10. Data show that POMP facilitates the main steps in 20S core complex formation at the ER to coordinate the assembly process and to provide cells with freshly formed proteasomes at their site of function. PMID: 17948026

    顯示更多

    收起更多

  • 相關疾病:
    Keratosis linearis with ichthyosis congenita and sclerosing keratoderma (KLICK)
  • 亞細胞定位:
    Cytoplasm, cytosol. Nucleus. Microsome membrane.
  • 蛋白家族:
    POMP/UMP1 family
  • 組織特異性:
    Strongly expressed from the basal layer to the granular layer of healthy epidermis, whereas in KLICK patients there is a gradual decrease of expression toward the granular layer.
  • 數據庫鏈接:

    HGNC: 20330

    OMIM: 601952

    KEGG: hsa:51371

    STRING: 9606.ENSP00000370222

    UniGene: Hs.268742



主站蜘蛛池模板: 国产成人一区二区无码不卡在线| 欧洲丰满大乳人妻无码欧美| 三个男人躁我一个爽视频免费| 成熟老妇女毛茸茸的做性| 人人妻碰人人免费| 国产99久久久欧美黑人刘玥| 色妞www精品视频| 深夜福利视频在线播放| 亚洲乱码中文字幕在线| 久久婷婷久久一区二区三区| 蜜臀av色欲a片无人一区| 人成午夜大片免费视频| 露脸内射熟女--69xx| 天天躁日日躁狠狠躁一区| 久久国产36精品色熟妇| 久久婷婷色香五月综合缴缴情| 亚洲人成77777在线播放网站| 亚洲精品国男人在线视频| 国产精品永久久久久久久久久| 蜜臀av无码人妻精品| 女人被狂躁c到高潮喷水电影| 亚洲 日韩 欧美 有码 在线| 国产性夜夜春夜夜爽免费下载| 午夜一区一品日本| 少妇人妻邻居| 亚洲精品熟女国产| 国产午夜精华无码网站| 无码伊人66久久大杳蕉网站谷歌| 亚洲国产精品第一区二区| 精品国精品国产自在久国产87| 永久免费无码成人网站| 国产欧美日韩亚洲精品专区| 性饥渴的农村熟妇| 亚洲国色天香卡2卡3卡4| 中文人妻熟妇乱又伦精品| 久久精品欧美日韩精品| 香蕉久久福利院| 国精品午夜福利视频不卡| 国产成人亚洲综合色婷婷秒播| 人妻丰满熟av无码区hd| 荫蒂被男人添的好舒服爽免费视频|