在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

POMP Antibody

  • 中文名稱:
    POMP兔多克隆抗體
  • 貨號:
    CSB-PA018365GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    POMP
  • 別名:
    2510048O06Rik antibody; C13orf12 antibody; Chromosome 13 open reading frame 12 antibody; HSPC 014 antibody; HSPC036 protein antibody; hUMP 1 antibody; hUMP1 antibody; PNAS 110 antibody; PNAS110 antibody; Pomp antibody; POMP_HUMAN antibody; Proteasome maturation protein antibody; Proteassemblin antibody; Protein UMP1 homolog antibody; UMP 1 antibody; UMP1 antibody; UMP1; yeast; homolog of antibody; Voltage gated K channel beta subunit 4.1 antibody; Voltage-gated K channel beta subunit 4.1 antibody; voltage-gated potassium channel beta subunit 4.1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human POMP
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the association of 20S preproteasome with the endoplasmic reticulum.
  • 基因功能參考文獻:
    1. POMP-related autoinflammation and immune dysregulation disease (PRAID) discovered in two unrelated individuals with a unique constellation of early-onset combined immunodeficiency, inflammatory neutrophilic dermatosis, and autoimmunity, is reported. PMID: 29805043
    2. POMP is overexpressed and participates in the increase of proteasome assembly and activity in psoriatic skin. PMID: 28728908
    3. MCM3AP and POMP Mutations Cause a DNA-Repair and DNA-Damage-Signaling Defect in an Immunodeficient Child PMID: 26615982
    4. studies validate a role for the NRF2/POMP axis in bortezomib resistance and identify NRF2 and POMP as potentially attractive targets for chemosensitization to this proteasome inhibitor PMID: 26483548
    5. microRNA-101 (miR-101) targets the proteasome maturation protein POMP, leading to impaired proteasome assembly and activity, and resulting in accumulation of p53 and cyclin-dependent kinase inhibitors, cell cycle arrest, and apoptosis. PMID: 26145175
    6. Single-nucleotide polymorphisms in POMP gene is associated with breast cancer risk after menopausal hormone replacement therapy. PMID: 24080446
    7. KLICK is caused by reduced levels of POMP, leading to proteasome insufficiency in differentiating keratinocytes PMID: 22235297
    8. A single-nucleotide deletion in the POMP 5' UTR causes a transcriptional switch and altered epidermal proteasome distribution in KLICK genodermatosis. PMID: 20226437
    9. POMP/proteassemblin/hUmp1 may be tetramerised and is localized to the cytoplasm and the nucleus PMID: 16624403
    10. Data show that POMP facilitates the main steps in 20S core complex formation at the ER to coordinate the assembly process and to provide cells with freshly formed proteasomes at their site of function. PMID: 17948026

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Keratosis linearis with ichthyosis congenita and sclerosing keratoderma (KLICK)
  • 亞細胞定位:
    Cytoplasm, cytosol. Nucleus. Microsome membrane.
  • 蛋白家族:
    POMP/UMP1 family
  • 組織特異性:
    Strongly expressed from the basal layer to the granular layer of healthy epidermis, whereas in KLICK patients there is a gradual decrease of expression toward the granular layer.
  • 數據庫鏈接:

    HGNC: 20330

    OMIM: 601952

    KEGG: hsa:51371

    STRING: 9606.ENSP00000370222

    UniGene: Hs.268742



主站蜘蛛池模板: 在线综合亚洲欧洲综合网站| 午夜福利视频| 亚洲精品久久久久中文第一幕| 纯肉无遮挡无码日本动漫| 亚洲精品无码专区在线| 永久免费不卡在线观看黄网站| 夜夜未满十八勿进的爽爽影院| 2018天天躁夜夜躁狠狠躁 | 国产一区二区在线影院| 国产丝袜在线精品丝袜| 国产女人乱子对白av片| 三级4级全黄60分钟| 97久久久人妻一区精品 | 西西4444www大胆无码| 亚洲性无码av中文字幕| 欧美日韩在手机线旡码可下载| 亚洲狠亚洲狠亚洲狠狠狠| 又爽又黄又无遮挡的视频| 老司机无码精品a| 不卡无码人妻一区二区三区| 极品少妇小泬50pthepon| 久久精品动漫一区二区三区| 野外少妇被弄到喷水在线观看| 国产精品亚洲а∨无码播放不卡| 久久久精品日本一区二区三区 | 亚洲a∨无码无在线观看| 又色又污又爽又黄的网站| 亚洲国产精品第一区二区三区| 特黄做受又粗又大又硬老头| 亚洲人精品午夜射精日韩| 性色av无码中文av有码vr| 四虎影视在线永久免费观看| 18禁黄网站禁片免费观看| 内射人妻无套中出无码| 午夜免费啪视频在线观看区| 日韩在线不卡免费视频一区| 巨胸美乳无码人妻视频| 亚洲精品无码成人片| 亚洲午夜久久久精品影院| 无码人妻精品一区二区蜜桃百度 | 久久中文精品无码中文字幕|