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  4. Recombinant Human Prostate tumor-overexpressed gene 1 protein (PTOV1)

Recombinant Human Prostate tumor-overexpressed gene 1 protein (PTOV1)

  • 中文名稱：
    人PTOV1重組蛋白
  • 貨號：
    CSB-YP769809HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人PTOV1重組蛋白
  • 貨號：
    CSB-EP769809HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人PTOV1重組蛋白
  • 貨號：
    CSB-EP769809HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人PTOV1重組蛋白
  • 貨號：
    CSB-BP769809HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人PTOV1重組蛋白
  • 貨號：
    CSB-MP769809HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    PTOV1
  • Uniprot No.：
  • 別名：
    PTOV1; ACID2; PP642; UNQ6127/PRO20092; Prostate tumor-overexpressed gene 1 protein; PTOV-1; Activator interaction domain-containing protein 2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-416
  • 氨基酸序列
    MVRPRRAPYR SGAGGPLGGR GRPPRPLVVR AVRSRSWPAS PRGPQPPRIR ARSAPPMEGA RVFGALGPIG PSSPGLTLGG LAVSEHRLSN KLLAWSGVLE WQEKRRPYSD STAKLKRTLP CQAYVNQGEN LETDQWPQKL IMQLIPQQLL TTLGPLFRNS QLAQFHFTNR DCDSLKGLCR IMGNGFAGCM LFPHISPCEV RVLMLLYSSK KKIFMGLIPY DQSGFVSAIR QVITTRKQAV GPGGVNSGPV QIVNNKFLAW SGVMEWQEPR PEPNSRSKRW LPSHVYVNQG EILRTEQWPR KLYMQLIPQQ LLTTLVPLFR NSRLVQFHFT KDLETLKSLC RIMDNGFAGC VHFSYKASCE IRVLMLLYSS EKKIFIGLIP HDQGNFVNGI RRVIANQQQV LQRNLEQEQQ QRGMGG
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation.
  • 基因功能參考文獻：
    1. The combination of PTOV1 expression level and HPV status provides more prognostic information compared with HPV status alone in early-stage human laryngeal squamous cell carcinoma. PMID: 26992242
    2. Studies indicate that the number of binding partners and associated cellular functions has increased and helped to identify prostate-tumor-overexpressed-1 (PTOV1) as regulator of gene expression at transcription and translation levels. PMID: 28029646
    3. this study takes the lead to demonstrate that the overexpressed PTOV1 plays a vital role in the tumorigenesis and progression of esophageal squamous cell carcinoma, and it is potentially a valuable prognostic predicator and new chemotherapeutic target for esophageal squamous cell carcinoma PMID: 28651486
    4. All the study samples showed a considerable decrease in PTOV1 expression in prostate cancer and HGPIN compared to morphologically normal glands. PMID: 27804940
    5. High PTOV1 expression was associated with invasive urothelial carcinoma. PMID: 26746655
    6. PTOV1 overexpression is associated with poor survival outcomes of nasopharyngeal carcinoma patients. PMID: 26305455
    7. PTOV1 protein abnormal expression might contribute to the malignant progression of epithelial ovarian cancer. PMID: 25270739
    8. Our study demonstrated that PTOV1 overexpression is correlated with increased aggressiveness of hepatocellular carcinoma and could be a prognostic biomarker for patients with HCC PMID: 25634174
    9. The study showed that PTOV1 is upregulated in breast cancer cell lines and clinical samples, and its expression was positively associated with progression and aggressiveness of breast cancer, suggesting that PTOV1 could serve as an independent prognostic marker. PMID: 24947166
    10. In prostate tumors, the overexpression of PTOV1 was associated with decreased expression of HEY1 and HES1, and this correlation was significant in metastatic lesions. PMID: 24684754
    11. RA-induced cancer cell cytotoxicity was significantly impaired by Zyxin or PTOV1. Overall, our findings suggest that Zyxin and PTOV1 should be considered as critical determinants in cancer therapy with retinoids PMID: 23321499
    12. alpha-Methyl-CoA racemase can be considered a more accurate marker than PTOV1 in the identification of high-grade prostatic intraepithelial neoplasia (HGPIN) and of prostate cancer. PMID: 22507319
    13. PTOV1 expression is associated to more aggressive human carcinomas and more significantly to bladder carcinomas suggesting that this protein is a potential new marker of aggressive disease in the latter tumors. PMID: 21181414
    14. MED25 and PTOV1 differentially modulate retinoic acid sensitivity in cancer cells depending on their expression levels. PMID: 21110951
    15. This protein, overexpressed in prostate cancer, shuttles between the cytoplasm and the nucleus and promotes entry into the S phase of the cell division cycle. PMID: 12598323
    16. PTOV1 assists flotillin-1 in its translocation to the nucleus and both proteins are required for cell proliferation. PMID: 15713644
    17. PTOV1 is overexpressed in high-grade prostatic intraepithelial neoplasia associated with cancer and is a potential marker for studying the carcinogenesis and progression of prostate cancer. PMID: 18451224

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  • 亞細胞定位：
    Cytoplasm. Nucleus. Cell membrane. Cytoplasm, perinuclear region.
  • 蛋白家族：
    Mediator complex subunit 25 family, PTOV1 subfamily
  • 組織特異性：
    Expressed in brain, heart, kidney, liver, placenta, skeletal muscle and small intestine.
  • 數據庫鏈接：

    HGNC: 9632

    OMIM: 610195

    KEGG: hsa:53635

    STRING: 9606.ENSP00000375717

    UniGene: Hs.587979



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