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  4. Recombinant Human Nucleolar and spindle-associated protein 1 (NUSAP1)

Recombinant Human Nucleolar and spindle-associated protein 1 (NUSAP1)

  • 中文名稱：
    人NUSAP1重組蛋白
  • 貨號：
    CSB-YP887151HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人NUSAP1重組蛋白
  • 貨號：
    CSB-EP887151HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人NUSAP1重組蛋白
  • 貨號：
    CSB-EP887151HU-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人NUSAP1重組蛋白
  • 貨號：
    CSB-BP887151HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人NUSAP1重組蛋白
  • 貨號：
    CSB-MP887151HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    NUSAP1
  • Uniprot No.：
  • 別名：
    2610201A12Rik; AI481307; ANKT; AW547774; BB165529; BM037; FLJ13421; LNP; Nucleolar and spindle associated protein 1; Nucleolar and spindle-associated protein 1; Nucleolar protein ANKT; NuSAP; NUSAP_HUMAN; nusap1; PRO0310p1; Q0310; RP23-22A15.4; SAPL
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區(qū)域：
    1-441
  • 氨基酸序列
    MIIPSLEELD SLKYSDLQNL AKSLGLRANL RATKLLKALK GYIKHEARKG NENQDESQTS ASSCDETEIQ ISNQEEAERQ PLGHVTKTRR RCKTVRVDPD SQQNHSEIKI SNPTEFQNHE KQESQDLRAT AKVPSPPDEH QEAENAVSSG NRDSKVPSEG KKSLYTDESS KPGKNKRTAI TTPNFKKLHE AHFKEMESID QYIERKKKHF EEHNSMNELK QQPINKGGVR TPVPPRGRLS VASTPISQRR SQGRSCGPAS QSTLGLKGSL KRSAISAAKT GVRFSAATKD NEHKRSLTKT PARKSAHVTV SGGTPKGEAV LGTHKLKTIT GNSAAVITPF KLTTEATQTP VSNKKPVFDL KASLSRPLNY EPHKGKLKPW GQSKENNYLN QHVNRINFYK KTYKQPHLQT KEEQRKKREQ ERKEKKAKVL GMRRGLILAE D
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Microtubule-associated protein with the capacity to bundle and stabilize microtubules. May associate with chromosomes and promote the organization of mitotic spindle microtubules around them.
  • 基因功能參考文獻：
    1. Study suggests that NUSAP1 might be involved in glioma progression and can serve as a prognosis biomarker for glioma patients. NUSAP1 silencing suppresses malignant phenotypes of glioma cells, which offer a theoretical foundation for further investigation of NUSAP1 as a possible target with advantages for glioma treatment. PMID: 29336114
    2. NUSAP1 is overexpressed in colon cancer and high expression of NUSAP1 acts as an independent predictive factor for poor prognosis in colon cancer PMID: 29853313
    3. Findings indicated that NUSAP1 played an important role in promoting aggressiveness in astrocytoma via activating the HH pathway. PMID: 28899410
    4. our work provides a better understanding of the function of NUSAP1 in aggressive prostate cancers, provides rationale for using NUSAP1 as a prognostic biomarker, and sets the stage for developing improved therapeutic strategies for prostate and other cancers. PMID: 28404898
    5. NUSAP1 contributes to accurate chromosome segregation by acting as a co-factor for RanBP2-RanGAP1-UBC9 during cell division. PMID: 28900032
    6. NuSAP governs chromosome oscillation via regulation of Kid, facilitating the Kid-generated polar ejection force. Depletion of NuSAP significantly suppresses the amplitude and velocity of chromosome oscillation. PMID: 26839278
    7. NUSAP1 may be a crucial biomarker for oral squamous cell carcinoma. down-regulated NUSAP1 expression suppresses tumor proliferation and also enhances anti-tumor effect of paclitaxel by activating apoptotic pathways. PMID: 26554377
    8. High levels of NuSAP1 expression were related to poor disease-free survival, particularly in triple-negative breast cancer. PMID: 26485712
    9. A novel association between BRCA1 and NUSAP1 is revealed and a mechanism whereby NUSAP1 is involved in carcinogenesis was elusidated. PMID: 24521615
    10. High NUSAP1 expression is associated with cervical cancer. PMID: 23405241
    11. NuSAP is a novel biomarker for prostate cancer recurrence after surgery and its overexpression appears to be driven in part by E2F1 activation PMID: 22349817
    12. Phosphorylation of NuSAP by Cdk1 is an important mechanism to regulate microtubule dynamics during cell cycle progression. PMID: 22101338
    13. Interphase NuSAP-chromatin interaction suggests additional functions for NuSAP, as recently identified for other nuclear spindle assembly factors with a role in gene expression or DNA damage response. PMID: 21782797
    14. NuSAP1 is recognized as an immunogenic antigen in 65% of patients with AML following allogeneic HCT and suggests a tumor antigen role. PMID: 20053754

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  • 亞細胞定位：
    Cytoplasm. Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Chromosome.
  • 蛋白家族：
    NUSAP family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18538

    OMIM: 612818

    KEGG: hsa:51203

    STRING: 9606.ENSP00000453403

    UniGene: Hs.615092



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