在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Monocarboxylate transporter 12 (SLC16A12), partial

Recombinant Human Monocarboxylate transporter 12 (SLC16A12), partial

  • 中文名稱：
    人SLC16A12重組蛋白
  • 貨號：
    CSB-YP757957HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SLC16A12重組蛋白
  • 貨號：
    CSB-EP757957HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SLC16A12重組蛋白
  • 貨號：
    CSB-EP757957HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SLC16A12重組蛋白
  • 貨號：
    CSB-BP757957HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SLC16A12重組蛋白
  • 貨號：
    CSB-MP757957HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SLC16A12
  • Uniprot No.：
  • 別名：
    SLC16A12; MCT12; Monocarboxylate transporter 12; MCT 12; Creatine transporter 2; CRT2; Solute carrier family 16 member 12
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Proton-linked monocarboxylate transporter that mediates creatine transport across the plasma membrane.
  • 基因功能參考文獻：
    1. We screened the coding exons of the gene SLC16A12 in 877 patients. Their impact on creatine transport was tested in Xenopus laevis oocytes and human HEK293T cells. Four variants (p.Ser158Pro, p.Gly205Val, p.Pro395Gln and p.Ser453Arg) displayed severe reduction in both model systems. Our findings provide insight into molecular requirements of creatine transporter. PMID: 29088427
    2. our data indicate that MCT12 functions as a basolateral exit pathway for creatine in the proximal tubule. Heterozygous mutation of MCT12 affects systemic levels and renal handling of guanidinoacetate, possibly through an indirect mechanism. Furthermore, our data reveal a digenic syndrome in the index family, with simultaneous MCT12 and SGLT2 mutation. Thus, glucosuria is not part of the MCT12 mutation syndrome PMID: 26376857
    3. study identified a second creatine transporter monocarboxylate transporter 12 (MCT12), encoded by the cataract and glucosuria associated gene SLC16A12; Rssults show SLC6A8 was predominantly found in brain, heart and muscle, while SLC16A12 was more abundant in kidney and retina. In the lens, the two transcripts were found at comparable levels. PMID: 23578822
    4. The monocarboxylate transporter SLC16A12 may contribute to age-related cataract. Sequences within the 5'UTR modulate translational efficiency with pathogenic consequences. PMID: 20181839
    5. Observational study of gene-disease association. (HuGE Navigator) PMID: 20181839
    6. SLC16A12 is important for lens and kidney homeostasis; its potential role in age-related cataract is discussed. PMID: 18304496
    7. Observational study of gene-disease association. (HuGE Navigator) PMID: 16385451

    顯示更多

    收起更多

  • 相關疾病：
    Cataract 47 (CTRCT47)
  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Major facilitator superfamily, Monocarboxylate porter (TC 2.A.1.13) family
  • 組織特異性：
    Most highly expressed in kidney, followed by retina, lung, heart and testis. Very weakly expressed in brain and liver. Also detected in lens.
  • 數據庫鏈接：

    HGNC: 23094

    OMIM: 611910

    KEGG: hsa:387700

    STRING: 9606.ENSP00000360855

    UniGene: Hs.530338



主站蜘蛛池模板： 国产一性一交一伦一a片| 欧美大屁股xxxx高跟欧美黑人| 蜜臀av一区二区| 亚洲中文色欧另类欧美| 欧美毛多水多黑寡妇| 久久国产精品免费一区| 久久草莓香蕉频线观| 国产精品久久久久久人妻精品| 超碰国产精品久久国产精品99| 韩国精品福利一区二区三区| 国产精品成人永久在线| 久久久女人与动物群交毛片| 18禁又污又黄又爽的网站不卡| 日日天干夜夜狠狠爱| 久久久亚洲欧洲日产国产成人无码| 又色又爽又黄的gif动态图| 国产在线码观看超清无码视频| 精品国产成人网站一区在线| 国产suv精品一区二区33| 国产成人无码区免费内射一片色欲| 无码中文av有码中文a| 亚洲人成网站18禁止大| 无码少妇一区二区三区视频| 色婷婷综合激情综在线播放| 熟妇人妻无码中文字幕老熟妇| 欧美黑人巨大videos精品男男| 男女啪啦猛视频免费| 特级毛片a片久久久久久 | 236宅宅理论片免费| 卡一卡二卡三免费视频| 国产午夜亚洲精品不卡| 国产精品久久人妻无码网站蜜臀| 欧洲免费一区二区三区视频| 日日碰狠狠添天天爽无码| 日本肉体xxxx裸交| 免费高清av一区二区三区| 国产成人人综合亚洲欧美丁香花 | 国产99久久久国产无需播放器| 一边吃奶一边做动态图| 日本乱子人伦在线视频| 嫖妓丰满肥熟妇在线精品|