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  4. SLC16A12 Antibody

SLC16A12 Antibody

  • 中文名稱：
    SLC16A12兔多克隆抗體
  • 貨號：
    CSB-PA757957LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: Jurkat whole cell lysate, 293 whole cell lysate, Hela whole cell lysate, HepG2 whole cell lysate
      All lanes: SLC16A12 antibody at 3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 54 kDa
      Observed band size: 54 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA757957LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA757957LA01HU at dilution of 1:100
    • Immunofluorescence staining of HepG2 cells with CSB-PA757957LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SLC16A12 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SLC16A12
  • 別名：
    SLC16A12 antibody; MCT12 antibody; Monocarboxylate transporter 12 antibody; MCT 12 antibody; Creatine transporter 2 antibody; CRT2 antibody; Solute carrier family 16 member 12 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Monocarboxylate transporter 12 protein (431-486AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，SLC16A12 Antibody (CSB-PA757957LA01HU)，的標記方式是Non-conjugated。對于SLC16A12 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA757957LB01HU SLC16A12 Antibody, HRP conjugated ELISA
    FITC CSB-PA757957LC01HU SLC16A12 Antibody, FITC conjugated
    Biotin CSB-PA757957LD01HU SLC16A12 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:200-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Proton-linked monocarboxylate transporter that mediates creatine transport across the plasma membrane.
  • 基因功能參考文獻：
    1. We screened the coding exons of the gene SLC16A12 in 877 patients. Their impact on creatine transport was tested in Xenopus laevis oocytes and human HEK293T cells. Four variants (p.Ser158Pro, p.Gly205Val, p.Pro395Gln and p.Ser453Arg) displayed severe reduction in both model systems. Our findings provide insight into molecular requirements of creatine transporter. PMID: 29088427
    2. our data indicate that MCT12 functions as a basolateral exit pathway for creatine in the proximal tubule. Heterozygous mutation of MCT12 affects systemic levels and renal handling of guanidinoacetate, possibly through an indirect mechanism. Furthermore, our data reveal a digenic syndrome in the index family, with simultaneous MCT12 and SGLT2 mutation. Thus, glucosuria is not part of the MCT12 mutation syndrome PMID: 26376857
    3. study identified a second creatine transporter monocarboxylate transporter 12 (MCT12), encoded by the cataract and glucosuria associated gene SLC16A12; Rssults show SLC6A8 was predominantly found in brain, heart and muscle, while SLC16A12 was more abundant in kidney and retina. In the lens, the two transcripts were found at comparable levels. PMID: 23578822
    4. The monocarboxylate transporter SLC16A12 may contribute to age-related cataract. Sequences within the 5'UTR modulate translational efficiency with pathogenic consequences. PMID: 20181839
    5. Observational study of gene-disease association. (HuGE Navigator) PMID: 20181839
    6. SLC16A12 is important for lens and kidney homeostasis; its potential role in age-related cataract is discussed. PMID: 18304496
    7. Observational study of gene-disease association. (HuGE Navigator) PMID: 16385451

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  • 相關疾病：
    Cataract 47 (CTRCT47)
  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Major facilitator superfamily, Monocarboxylate porter (TC 2.A.1.13) family
  • 組織特異性：
    Most highly expressed in kidney, followed by retina, lung, heart and testis. Very weakly expressed in brain and liver. Also detected in lens.
  • 數據庫鏈接：

    HGNC: 23094

    OMIM: 611910

    KEGG: hsa:387700

    STRING: 9606.ENSP00000360855

    UniGene: Hs.530338



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