在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Major facilitator superfamily domain-containing protein 2A (MFSD2A), partial

Recombinant Human Major facilitator superfamily domain-containing protein 2A (MFSD2A), partial

  • 中文名稱：
    人MFSD2A重組蛋白
  • 貨號：
    CSB-YP847667HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人MFSD2A重組蛋白
  • 貨號：
    CSB-EP847667HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人MFSD2A重組蛋白
  • 貨號：
    CSB-EP847667HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人MFSD2A重組蛋白
  • 貨號：
    CSB-BP847667HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人MFSD2A重組蛋白
  • 貨號：
    CSB-MP847667HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    MFSD2A
  • Uniprot No.：
  • 別名：
    1700018O18Rik; FLJ14490; FLJ35904; Major facilitator superfamily domain containing 2; Major facilitator superfamily domain containing 2A; Major facilitator superfamily domain-containing protein 2A; MFS2A_HUMAN; MFSD2; MFSD2A; RGD1310174; RP23-121J14.3
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Does not transport docosahexaenoic acid in unesterified fatty acid. Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport. Not required for central nervous system vascular morphogenesis. Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation. In placenta, acts as a receptor for ERVFRD-1/syncytin-2 and is required for trophoblast fusion.
  • 基因功能參考文獻：
    1. In offspring of women with gestational diabetes mellitus treated either with diet or insulin, higher fetal fat accretion and lower placental MFSD2a contribute to reduce docosahexaenoic acid availability. PMID: 26869380
    2. Levels of DHA-derived epoxides are lower in colon tissues from patients with ulcerative colitis than healthy and resolving mucosa. Production of these metabolites by gut endothelium requires MFSD2A; endothelial progenitor cells that overexpress MFSD2A reduce colitis in mice. PMID: 28827082
    3. The regulatory role of Mfsd2a deepens our knowledge of the function of the BBB, potentially contributing to the effective drug delivery in the treatments for neurodegenerative diseases, brain tumors, and life-threatening infections in the CNS PMID: 26747400
    4. MFSD2A transported structurally related acylcarnitines but not a lysolipid without a negative charge, demonstrating the necessity of a negatively charged headgroup interaction with Lys-436 for transport. PMID: 26945070
    5. A homozygous mutation affecting a highly conserved MFSD2A residue (p.Ser339Leu) is associated with a progressive microcephaly syndrome characterized by intellectual disability, spasticity and absent speech. PMID: 26005865
    6. MFSD2A mutations impair brain lipid transport activity. PMID: 26005868
    7. Several tagging SNPs and haplotypes in TRIT1, MYCL1 and MFSD2A region are significantly associated with risk and clinicopathological features of gastric cancer in a Chinese population. PMID: 23349019
    8. Importance of MFSD2a in trophoblast fusion and placenta development. PMID: 23177091
    9. SNP rs12072037 modulates MFSD2A promoter activity and thus might affect MFSD2A levels in normal lung and in lung tumors. PMID: 21736709
    10. MFSD2A is a putative Tunicamycin transporter at the plasma membrane. PMID: 21677192
    11. MFSD2A is a novel lung cancer tumor suppressor gene that regulates cell cycle progression and matrix attachment. PMID: 20236515
    12. three additional SNPs in the MFSD2 genes showed ethnic differences in allelic frequencies PMID: 17145094
    13. Results identify Mfsd2a (major facilitator superfamily domain-containing protein 2a) and an additional closely related protein Mfsd2b, and suggest that Mfsd2a plays a role in adaptive thermogenesis. PMID: 18694395
    14. MFSD2 is a placenta-specific receptor for the fusogenic, endogenous retrovirus-derived, human syncytin-2, and plays a role in placenta morphogenesis. PMID: 18988732

    顯示更多

    收起更多

  • 相關疾病：
    Microcephaly 15, primary, autosomal recessive (MCPH15)
  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Major facilitator superfamily
  • 組織特異性：
    In placenta, associated with trophoblast cells.
  • 數據庫鏈接：

    HGNC: 25897

    OMIM: 614397

    KEGG: hsa:84879

    STRING: 9606.ENSP00000361895

    UniGene: Hs.655177



主站蜘蛛池模板： 亚洲日韩中文字幕无码一区| 人妻夜夜爽天天爽三区| 国产爆乳无码一区二区麻豆| 国产精品自在线拍国产| 四虎永久在线精品视频免费观看| 国产黄网永久免费视频大全| 色噜噜狠狠色综合网| 中文资源在线天堂库8| 伊人久久亚洲综合影院首页| 美女扒开大腿让男人桶| 疯狂做受xxxx高潮视频免费| 7m精品福利视频导航| 国内久久婷婷五月综合色| 国产乱人伦av在线麻豆a| 色妺妺视频网| 欧美老妇大p毛茸茸| 久久国产成人免费网站| 女人扒下裤让男人桶到爽| 亚洲人成小说网站色| 国产一在线精品一区在线观看| 午夜福利理论片在线观看播放| 九月婷婷人人澡人人添人人爽| 国产精品 自在自线| 国产精品va在线观看老妇女| 久久九九有精品国产尤物| 国产中文字字幕乱码无限| 高清欧美性猛交xxxx黑人猛交| 99久久国产露脸精品国产麻豆| 免费人成视频在线播放视频| 亚洲精品国偷拍自产在线观看蜜桃| 四虎影视成人永久免费观看视频| 人人爽人人爽人人片a| 无码人妻精品一区二区三区久久 | 狠狠色色综合站| 天天躁日日躁狠狠躁视频2021| 国产精品sp调教打屁股| 99久久99久久久精品齐齐综合色圆| 鲁一鲁一鲁一鲁一曰综合网 | 国产sm调教视频在线观看| 免费观看的av在线播放| 久久国产免费观看精品3|