在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MFSD2A Antibody

  • 中文名稱:
    MFSD2A兔多克隆抗體
  • 貨號:
    CSB-PA196650
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA196650 (MFSD2A Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human placenta tissue lysate, Primary antibody: CSB-PA196650 (MFSD2A Antibody) at dilution 1/500, Secondary antibody: D110058(HRP-conjugated Goat anti rabbit IgG) at 1/5000 dilution, Exposure time: 1 minute
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    MFSD2A
  • 別名:
    1700018O18Rik antibody; FLJ14490 antibody; FLJ35904 antibody; Major facilitator superfamily domain containing 2 antibody; Major facilitator superfamily domain containing 2A antibody; Major facilitator superfamily domain-containing protein 2A antibody; MFS2A_HUMAN antibody; MFSD2 antibody; MFSD2A antibody; RGD1310174 antibody; RP23-121J14.3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthetic peptide of Human MFSD2A
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Does not transport docosahexaenoic acid in unesterified fatty acid. Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport. Not required for central nervous system vascular morphogenesis. Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation. In placenta, acts as a receptor for ERVFRD-1/syncytin-2 and is required for trophoblast fusion.
  • 基因功能參考文獻:
    1. In offspring of women with gestational diabetes mellitus treated either with diet or insulin, higher fetal fat accretion and lower placental MFSD2a contribute to reduce docosahexaenoic acid availability. PMID: 26869380
    2. Levels of DHA-derived epoxides are lower in colon tissues from patients with ulcerative colitis than healthy and resolving mucosa. Production of these metabolites by gut endothelium requires MFSD2A; endothelial progenitor cells that overexpress MFSD2A reduce colitis in mice. PMID: 28827082
    3. The regulatory role of Mfsd2a deepens our knowledge of the function of the BBB, potentially contributing to the effective drug delivery in the treatments for neurodegenerative diseases, brain tumors, and life-threatening infections in the CNS PMID: 26747400
    4. MFSD2A transported structurally related acylcarnitines but not a lysolipid without a negative charge, demonstrating the necessity of a negatively charged headgroup interaction with Lys-436 for transport. PMID: 26945070
    5. A homozygous mutation affecting a highly conserved MFSD2A residue (p.Ser339Leu) is associated with a progressive microcephaly syndrome characterized by intellectual disability, spasticity and absent speech. PMID: 26005865
    6. MFSD2A mutations impair brain lipid transport activity. PMID: 26005868
    7. Several tagging SNPs and haplotypes in TRIT1, MYCL1 and MFSD2A region are significantly associated with risk and clinicopathological features of gastric cancer in a Chinese population. PMID: 23349019
    8. Importance of MFSD2a in trophoblast fusion and placenta development. PMID: 23177091
    9. SNP rs12072037 modulates MFSD2A promoter activity and thus might affect MFSD2A levels in normal lung and in lung tumors. PMID: 21736709
    10. MFSD2A is a putative Tunicamycin transporter at the plasma membrane. PMID: 21677192
    11. MFSD2A is a novel lung cancer tumor suppressor gene that regulates cell cycle progression and matrix attachment. PMID: 20236515
    12. three additional SNPs in the MFSD2 genes showed ethnic differences in allelic frequencies PMID: 17145094
    13. Results identify Mfsd2a (major facilitator superfamily domain-containing protein 2a) and an additional closely related protein Mfsd2b, and suggest that Mfsd2a plays a role in adaptive thermogenesis. PMID: 18694395
    14. MFSD2 is a placenta-specific receptor for the fusogenic, endogenous retrovirus-derived, human syncytin-2, and plays a role in placenta morphogenesis. PMID: 18988732

    顯示更多

    收起更多

  • 相關疾病:
    Microcephaly 15, primary, autosomal recessive (MCPH15)
  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Major facilitator superfamily
  • 組織特異性:
    In placenta, associated with trophoblast cells.
  • 數據庫鏈接:

    HGNC: 25897

    OMIM: 614397

    KEGG: hsa:84879

    STRING: 9606.ENSP00000361895

    UniGene: Hs.655177



主站蜘蛛池模板: 日韩精品无码视频一区二区蜜桃| 亚洲伊人久久大香线蕉av| 夜夜添无码一区二区三区| 欧美孕妇变态重口另类| 男女高潮又爽又黄又无遮挡| 丰满岳乱妇在线观看中字| 日日摸夜夜摸狠狠摸婷婷| 性暴力欧美猛交在线播放| 无码少妇一区二区三区| 日本高清视频色wwwwww色| 欧美肥老太牲交| 亚洲欧美日韩综合俺去了| 久久国产欧美日韩精品| 国产99久久久国产精品免费看 | 又爽又黄又无遮挡网站| 在线观看片免费视频无码| 精品无码一区二区三区| 女人被狂躁60分钟视频| 无码国产玉足脚交极品播放| 日本乱妇乱子视频| 人妻在卧室被老板疯狂进入| 妺妺窝人体色www在线下载| 久久99精品国产麻豆蜜芽| 亚洲中文有码字幕日本第一页| 骚动漫十八禁在线观看| 精品久久久久久| 最爽无遮挡行房视频| 狠狠色成人一区二区三区| 久久久久欧美精品观看| 精品无码一区二区三区的天堂| 中国女人内谢69xxxx| 正在播放国产真实哭都没用| 色老头精品午夜福利视频| 女女女女女裸体处开bbb| 久久人人爽人人爽人人片ⅴ| 水蜜桃精品一二三| 久久久久久亚洲综合影院| 男人的天堂在线视频 | 国产色在线 | 国产| 亚洲1卡二卡三新区2022| 欧美xxxxx高潮喷水|