在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Lymphocyte antigen 6E (LY6E) (Active)

In Stock
  • 貨號:
    CSB-MP619076HU
  • 規格:
    ¥1536
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Activity
      Measured by its binding ability in a functional ELISA. Immobilized Human LY6E protein at 2 μg/ml can bind Anti-LY6E recombinant antibody (CSB-RA619076MA1HU). The EC50 is 2.483-3.282 ng/mL. Biological Activity Assay
  • 其他:

產品詳情

  • 純度:
    Greater than 95% as determined by SDS-PAGE.
  • 內毒素:
    Less than 1.0 EU/ug as determined by LAL method.
  • 生物活性:
    Measured by its binding ability in a functional ELISA. Immobilized Human LY6E protein at 2 μg/mL can bind Anti-LY6E recombinant antibody (CSB-RA619076MA1HU). The EC50 is 2.483-3.282 ng/mL.
  • 基因名:
  • Uniprot No.:
  • 別名:
    Lymphocyte antigen 6E; Ly-6E;Retinoic acid-induced gene E protein?(RIG-E); Stem cell antigen 2?(SCA-2); Thymic shared antigen 1?(TSA-1); LY6E; 9804,?RIGE,?SCA2,?TSA1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    Mammalian cell
  • 分子量:
    34.6 kDa
  • 表達區域:
    21-101aa
  • 氨基酸序列
    LMCFSCLNQKSNLYCLKPTICSDQDNYCVTVSASAGIGNLVTFGHSLSKTCSPACPIPEGVNVGVASMGISCCQSFLCNFS
  • 蛋白標簽:
    N-terminal hFc-tagged
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from a 0.2 μm filtered PBS, 6% Trehalose, pH 7.4
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation. Restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. Plays also an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity.; (Microbial infection) Promotes entry, likely through an enhanced virus-cell fusion process, of various viruses including HIV-1, West Nile virus, dengue virus and Zika virus. In contrast, the paramyxovirus PIV5, which enters at the plasma membrane, does not require LY6E. Mechanistically, adopts a microtubule-like organization upon viral infection and enhances viral uncoating after endosomal escape.
  • 基因功能參考文獻:
    1. LY6E belongs to a growing class of interferon-inducible factors that broadly enhance viral infectivity in an interferon-independent manner. PMID: 30190477
    2. LY6E knockdown by targeted-siRNA inhibited gastric cancer cell survival and proliferation and induced G1-S cell cycle arrest and apoptosis in gastric cancer cells PMID: 29448250
    3. High LY6E expression is associated with breast cancer. PMID: 27589564
    4. LY6E overexpression is associated with Breast Cancer Progression, Immune Escape, and Drug Resistance. PMID: 27197181
    5. LY6E is a positive modulator of HIV-1 infection in primary human peripheral blood mononuclear cells, immortalized CD4+ T lymphoid cells, and macrophages. HIV Long Terminal Repeat-driven HIV-1 gene expression is also enhanced by LY6E, suggesting additional roles of LY6E in HIV-1 replication. PMID: 28130445
    6. LY6E level of gene expression may serve as good biomarkers for systemic lupus erythematosus diagnosis. PMID: 25344775
    7. the LY6E pathway in monocytes represents one of negative feedback mechanisms that counterbalance monocyte activation which may serve as a potential target for immune intervention. PMID: 25225669
    8. This study suggested that a mutation in SCA2 or SCA3/MJD may be one of the genetic causes of Parkinson's disease in china. PMID: 19672991
    9. Increased expression of the type I interferon-inducible gene, lymphocyte antigen 6 complex locus E, in peripheral blood cells is predictive of lupus activity in a large cohort of Chinese lupus patients. PMID: 18755862
    10. Two SCA3 and one SCA2 cases have been identified which show autosomal dominant inheritance in Parkinson disease. PMID: 18990604

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 組織特異性:
    Widely expressed, predominantly in liver, kidney, ovary, spleen and peripheral blood Leukocytes.
  • 數據庫鏈接:

    HGNC: 6727

    OMIM: 601384

    KEGG: hsa:4061

    STRING: 9606.ENSP00000292494

    UniGene: Hs.521903



主站蜘蛛池模板: 中文字幕久久精品波多野结百度| 国产区又黄又硬高潮的视频| 在线天堂资源www在线污| 韩国 欧美 日产 国产精品| 潮喷无码正在播放| 国产精品久久久福利| 女人下边被添全过视频的网址| 国产乱对白刺激视频| 国色精品卡一卡2卡3卡4卡在线| 麻婆豆传媒一区二区三区| 日本少妇自慰免费完整版| 少妇把腿扒开让我舔18| 猫咪av成人永久网站在线观看| 亚洲欧美日韩愉拍自拍美利坚| 麻豆视传媒官网免费观看| 女厕厕露p撒尿八个少妇| 亚洲精品自在在线观看| 99精品国产99久久久久久97| 午夜爽爽爽男女污污污网站| 欧美成人无码a区视频在线观看| 婷婷成人综合激情在线视频播放| 人妻被按摩师玩弄到潮喷| 日本高清va在线播放| 午夜嘿嘿嘿影院| 亚洲欧美精品aaaaaa片| 亚洲午夜无码久久久久蜜臀av| 日本丰满老妇bbw| av无码免费永久在线观看| 无码人妻精品一区二区三区99不卡| 亚洲妇女行蜜桃av网网站| 琪琪午夜理论片福利在线观看| 夜夜躁很很躁日日躁麻豆| 一个人看的www免费视频在线观看| 免费裸体黄网站18禁免费| 中国熟妇内谢69xxxxx| 越南毛茸茸的少妇| 女邻居的大乳中文字幕| 国产精品一区在线蜜臀| 国产伦精品一区二区三区免.费| 成品人视频ww入口| 青草影院内射中出高潮|