在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 重組抗體
  4. LY6E Recombinant Monoclonal Antibody

LY6E Recombinant Monoclonal Antibody

  • 中文名稱：
    LY6E Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA619076MA1HU
  • 規格：
    ￥1320
  • 圖片：
    • Immunofluorescence staining of A549 cell with CSB-RA619076MA1HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG(H+L).
    • The Binding Activity of Human LY6E with Anti-LY6E recombinant antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human LY6E protein (CSB-MP619076HU) at 2 μg/mL can bind Anti-LY6E recombinant antibody. The EC50 is 2.483-3.282 ng/mL.
  • 其他：

產品詳情

  • 產品描述：
    CSB-RA619076MA1HU LY6E重組單克隆抗體是專為科研實驗設計的高特異性檢測工具，靶向淋巴細胞抗原6復合物E（LY6E）蛋白。該蛋白作為干擾素刺激基因產物，在固有免疫應答中發揮重要作用，尤其參與調控病毒入侵及宿主防御機制。本產品經ELISA及免疫熒光（IF）技術嚴格驗證，在IF實驗中呈現優異性能，推薦使用稀釋比為1:50至1:200時可實現清晰的靶蛋白定位與低背景信號，適用于細胞或組織樣本中LY6E的亞細胞分布研究。其在病毒感染模型、宿主-病原體互作機制探索、免疫調節通路分析等基礎研究領域具有廣泛應用價值，可為病毒受體功能研究、抗病毒蛋白網絡解析等實驗提供可靠支持。該重組單克隆抗體具有高親和力與批次間一致性，能夠滿足蛋白質相互作用分析、免疫熒光共定位等精細化實驗需求，為長期科研項目提供穩定的檢測保障。
  • Uniprot No.：
  • 基因名：
  • 別名：
    LY6E antibody; 9804 antibody; RIGE antibody; SCA2 antibody; TSA1 antibody; Lymphocyte antigen 6E antibody; Ly-6E antibody; Retinoic acid-induced gene E protein antibody; RIG-E antibody; Stem cell antigen 2 antibody; SCA-2 antibody; Thymic shared antigen 1 antibody; TSA-1 antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human LY6E protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    mIgG2a
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    29C11
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation. Restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. Plays also an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity.; (Microbial infection) Promotes entry, likely through an enhanced virus-cell fusion process, of various viruses including HIV-1, West Nile virus, dengue virus and Zika virus. In contrast, the paramyxovirus PIV5, which enters at the plasma membrane, does not require LY6E. Mechanistically, adopts a microtubule-like organization upon viral infection and enhances viral uncoating after endosomal escape.
  • 基因功能參考文獻：
    1. LY6E belongs to a growing class of interferon-inducible factors that broadly enhance viral infectivity in an interferon-independent manner. PMID: 30190477
    2. LY6E knockdown by targeted-siRNA inhibited gastric cancer cell survival and proliferation and induced G1-S cell cycle arrest and apoptosis in gastric cancer cells PMID: 29448250
    3. High LY6E expression is associated with breast cancer. PMID: 27589564
    4. LY6E overexpression is associated with Breast Cancer Progression, Immune Escape, and Drug Resistance. PMID: 27197181
    5. LY6E is a positive modulator of HIV-1 infection in primary human peripheral blood mononuclear cells, immortalized CD4+ T lymphoid cells, and macrophages. HIV Long Terminal Repeat-driven HIV-1 gene expression is also enhanced by LY6E, suggesting additional roles of LY6E in HIV-1 replication. PMID: 28130445
    6. LY6E level of gene expression may serve as good biomarkers for systemic lupus erythematosus diagnosis. PMID: 25344775
    7. the LY6E pathway in monocytes represents one of negative feedback mechanisms that counterbalance monocyte activation which may serve as a potential target for immune intervention. PMID: 25225669
    8. This study suggested that a mutation in SCA2 or SCA3/MJD may be one of the genetic causes of Parkinson's disease in china. PMID: 19672991
    9. Increased expression of the type I interferon-inducible gene, lymphocyte antigen 6 complex locus E, in peripheral blood cells is predictive of lupus activity in a large cohort of Chinese lupus patients. PMID: 18755862
    10. Two SCA3 and one SCA2 cases have been identified which show autosomal dominant inheritance in Parkinson disease. PMID: 18990604

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 組織特異性：
    Widely expressed, predominantly in liver, kidney, ovary, spleen and peripheral blood Leukocytes.
  • 數據庫鏈接：

    HGNC: 6727

    OMIM: 601384

    KEGG: hsa:4061

    STRING: 9606.ENSP00000292494

    UniGene: Hs.521903



主站蜘蛛池模板： 真人抽搐一进一出gif| 午夜男女xx00视频福利| 狠狠色综合tv久久久久久| 麻花豆传媒剧国产免费mv入口| 国产人妻人伦精品1国产| 国产精品午夜福利不卡| 国产三级aⅴ在在线观看| 亚洲精品国偷拍自产在线观看蜜桃| 髙清国产性猛交xxxand| 99视频精品全部免费 在线| 午夜伦yy44880影院| 亚洲成在人线在线播放无码vr| 亚洲乱色熟女一区二区三区丝袜| 国产精品久久久久久久久免费| 狠狠人妻久久久久久综合| 亚洲va天堂va欧美ⅴa在线| 亚洲精品一区二区国产精华液| 中日韩精品视频在线观看| 亚洲香蕉成人av网站在线观看| 无码国产成人午夜视频在线播放| 亚洲成在人线a免费77777| 中文字幕久久精品无码| 中文无码乱人伦中文视频在线| 人禽杂交18禁网站免费| 无翼乌工口全彩肉肉无遮挡18| 插插插精品亚洲一区| 国产99在线 | 欧美| 无码专区男人本色| 热99re久久精品天堂| 国产成人精品自在线拍| 国产熟女一区二区三区五月婷| 狂野av人人澡人人添| 免费人成网站在线视频| 国产又色又爽又刺激在线播放| 艳妇乳肉豪妇荡乳xxx| 免费国产午夜理论片不卡| 精品无码成人网站久久久久久| 999久久久国产精品| 无码一区二区三区中文字幕| 18禁男女污污污午夜网站免费暖暖| 久久久久av无码免费网|