在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Lymphocyte antigen 6E (LY6E)

  • 中文名稱:
    人LY6E重組蛋白
  • 貨號:
    CSB-YP619076HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人LY6E重組蛋白
  • 貨號:
    CSB-EP619076HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人LY6E重組蛋白
  • 貨號:
    CSB-BP619076HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    LY6E; 9804; RIGE; SCA2; TSA1; Lymphocyte antigen 6E; Ly-6E; Retinoic acid-induced gene E protein; RIG-E; Stem cell antigen 2; SCA-2; Thymic shared antigen 1; TSA-1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    21-101
  • 氨基酸序列
    LMCFSCLNQK SNLYCLKPTI CSDQDNYCVT VSASAGIGNL VTFGHSLSKT CSPACPIPEG VNVGVASMGI SCCQSFLCNF S
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

問答及客戶評論

 常見問題解答
Q:

I recently purchased this protein. And I would like to know:
1.Can you clarify if there is a His6 vs His10 tag?
2.Can you provide the sequence of the SUMO tag and clarify if it was cleaved post purification?

A:
Thanks for your feedback.
1.SUMO enzyme (also known as ULP1 protease) can be used to remove the N-terminal 6xHis-SUMO-tag, however, the success rate for cleavage is not very high, only 50% (The sumo enzyme recognizes the sumo spatial structure.). Meanwhile, the protein loss will be relatively large after cleavage. So we don't suggest you to remove the tag yourselves.
2.If you would like no-tagged protein, we could re-design primers, adding other restriction sites for tag removal. The success rate will be higher than 85%.
If we succed in removing the tag, we will charge you for protein production cost + tag removal cost.
If we fail in removing the tag, we will send you the tagged protein and will only charge you for protein production cost.
3.If you are worried that the lead time for the above proposal is too long, we could also try to remove the tag from the previous lot of protein (Lot03613). However, the success rate will be only 50%.

靶點詳情

  • 功能:
    GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation. Restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. Plays also an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity.; (Microbial infection) Promotes entry, likely through an enhanced virus-cell fusion process, of various viruses including HIV-1, West Nile virus, dengue virus and Zika virus. In contrast, the paramyxovirus PIV5, which enters at the plasma membrane, does not require LY6E. Mechanistically, adopts a microtubule-like organization upon viral infection and enhances viral uncoating after endosomal escape.
  • 基因功能參考文獻:
    1. LY6E belongs to a growing class of interferon-inducible factors that broadly enhance viral infectivity in an interferon-independent manner. PMID: 30190477
    2. LY6E knockdown by targeted-siRNA inhibited gastric cancer cell survival and proliferation and induced G1-S cell cycle arrest and apoptosis in gastric cancer cells PMID: 29448250
    3. High LY6E expression is associated with breast cancer. PMID: 27589564
    4. LY6E overexpression is associated with Breast Cancer Progression, Immune Escape, and Drug Resistance. PMID: 27197181
    5. LY6E is a positive modulator of HIV-1 infection in primary human peripheral blood mononuclear cells, immortalized CD4+ T lymphoid cells, and macrophages. HIV Long Terminal Repeat-driven HIV-1 gene expression is also enhanced by LY6E, suggesting additional roles of LY6E in HIV-1 replication. PMID: 28130445
    6. LY6E level of gene expression may serve as good biomarkers for systemic lupus erythematosus diagnosis. PMID: 25344775
    7. the LY6E pathway in monocytes represents one of negative feedback mechanisms that counterbalance monocyte activation which may serve as a potential target for immune intervention. PMID: 25225669
    8. This study suggested that a mutation in SCA2 or SCA3/MJD may be one of the genetic causes of Parkinson's disease in china. PMID: 19672991
    9. Increased expression of the type I interferon-inducible gene, lymphocyte antigen 6 complex locus E, in peripheral blood cells is predictive of lupus activity in a large cohort of Chinese lupus patients. PMID: 18755862
    10. Two SCA3 and one SCA2 cases have been identified which show autosomal dominant inheritance in Parkinson disease. PMID: 18990604

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 組織特異性:
    Widely expressed, predominantly in liver, kidney, ovary, spleen and peripheral blood Leukocytes.
  • 數據庫鏈接:

    HGNC: 6727

    OMIM: 601384

    KEGG: hsa:4061

    STRING: 9606.ENSP00000292494

    UniGene: Hs.521903



主站蜘蛛池模板: 曰曰摸夜夜添夜夜添高潮出水| 久久国产人妻一区二区| 青青草免费国产线观720| 国产在线精品二区| 亚洲熟熟妇xxxx| 欧美巨大xxxx做受高清| 国产一区二区怡红院| 亚洲美女视频高清在线看| 色屁屁www影院免费观看| 五十路熟女丰满大屁股| 国产成人无码www免费视频播放| 国产a√精品区二区三区四区| 日本熟妇乱人伦xxxx| 天堂久久久久va久久久久| 日本爽爽爽爽爽爽在线观看免 | 青青草原精品99久久精品66| 无码 人妻 在线 视频| 女人被黑人躁得好爽视频| 9久9久女女热精品视频在线观看 | 中文字幕乱码在线播放| 在线观看无码不卡av中文| 麻豆国产成人av在线播放欲色 | 九九精品无码专区免费| 国产中文欧美日韩在线| 亚洲熟妇色自偷自拍另类| 精品人妻中文字幕有码在线| 欧美成人h亚洲综合在线观看 | 国产精品亚洲a∨天堂不卡| 亚洲日韩一区二区三区| 欧美黑人又粗又大高潮喷水 | 免费很黄无遮挡的视频| 国产熟妇另类久久久久| 99久久精品免费看国产一区二区三区| 国产免费爽爽视频| 国产成熟妇女性视频电影| 色中色成人导航| 18禁裸乳无遮挡啪啪无码免费| 欧洲女人牲交性开放视频| 日韩好精品视频你懂的| 中文字幕精品亚洲无线码二区| 蜜臀av色欲a片无码精品一区|