在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Long-chain-fatty-acid--CoA ligase 1 (ACSL1), partial, Biotinylated

  • 中文名稱:
    Recombinant Human Long-chain-fatty-acid--CoA ligase 1 (ACSL1), partial, Biotinylated
  • 貨號:
    CSB-EP001191HU1-B
  • 規格:
    ¥2532
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
  • Uniprot No.:
  • 別名:
    Acyl-CoA synthetase 1;ACS1;Arachidonate--CoA ligase;Long-chain acyl-CoA synthetase 1;LACS 1;Long-chain acyl-CoA synthetase 2;LACS 2;Long-chain fatty acid-CoA ligase 2;Palmitoyl-CoA ligase 1;Palmitoyl-CoA ligase 2;Phytanate--CoA ligase
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    120.3 kDa
  • 表達區域:
    46-698aa
  • 氨基酸序列
    TRPKPLKPPCDLSMQSVEVAGSGGARRSALLDSDEPLVYFYDDVTTLYEGFQRGIQVSNNGPCLGSRKPDQPYEWLSYKQVAELSECIGSALIQKGFKTAPDQFIGIFAQNRPEWVIIEQGCFAYSMVIVPLYDTLGNEAITYIVNKAELSLVFVDKPEKAKLLLEGVENKLIPGLKIIVVMDAYGSELVERGQRCGVEVTSMKAMEDLGRANRRKPKPPAPEDLAVICFTSGTTGNPKGAMVTHRNIVSDCSAFVKATENTVNPCPDDTLISFLPLAHMFERVVECVMLCHGAKIGFFQGDIRLLMDDLKVLQPTVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAALGCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGDIGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDVKKAILEDMVRLGKDSGLKPFEQVKGITLHPELFSIDNGLLTPTMKAKRPELRNYFRSQIDDLYSTIKV
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal MBP-tagged and C-terminal 6xHis-Avi-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate. Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs).
  • 基因功能參考文獻:
    1. These results suggest that ACSL1, ACSL4 and ACSL5 expression is regulated by ER signaling pathways and ACSL5 is a potential novel biomarker for predicting prognosis of breast cancer patients. PMID: 28498416
    2. Study identified a genetic variant in the 3'-UTR region of ACSL1 gene (rs8086) that may play a significant role in predicting outcomes of stage II/III patients with colon cancer, so that patients with T/T genotype had a significantly higher risk of tumor recurrence than those carrying at least one C allele. PMID: 27992526
    3. The mRNA levels of ACSL1 were positively associated with those of HBXIP in clinical breast cancer tissues. Thus, we conclude that the oncoprotein HBXIP is able to up-regulate ACSL1 through activating the transcriptional factor Sp1 in breast cancer. PMID: 28132807
    4. evidence in humans of ACSL1 SNPs associated with fasting glucose, diabetes, and subclinical atherosclerosis PMID: 26711138
    5. SRE motif in ACSL1 is essential for SREBP2-mediated activation of C-ACSL1 gene transcription. PMID: 26728456
    6. ACSL1 is a programmable mediator of insulin sensitivity and cellular lipid content. PMID: 25915184
    7. the cell surface protein CD36/FAT directly facilitates fatty acid transport across the plasma membrane, whereas the intracellular acyl-CoA synthetases FATP4 and ACSL1 enhance fatty acid uptake indirectly by metabolic trapping PMID: 24503477
    8. Data indicate that expression of miR-205 is negatively related to that of ACSL1 in clinical hepatocellular carcinoma (HCC) tissues. PMID: 24462768
    9. long-chain acyl-CoA synthetase 1 has a role in eicosapentaenoic acid suppression of palmitate-induced cytokine production PMID: 23433401
    10. Findings suggest that the ACSL1 gene polymorphism rs6552828 is not associated with elite endurance athletic status in Caucasians, yet a marginal association seems to exist for the Chinese (Han) male population. PMID: 22829935
    11. Data show that ACSL1 rs9997745 polymorphism influences metabolic syndrome risk, most likely via disturbances in fatty acid metabolism, which was modulated by dietary fat consumption, particularly PUFA intake, suggesting novel gene-nutrient interactions. PMID: 20176858
    12. Based on homology, two new isoforms for ACSL1 were predicted and characterized, one represented a switch of the Phe- to the Tyr-Gate domain motif, the other resulted from the exclusion of both. PMID: 16834775

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein.
  • 蛋白家族:
    ATP-dependent AMP-binding enzyme family
  • 組織特異性:
    Highly expressed in liver, heart, skeletal muscle, kidney and erythroid cells, and to a lesser extent in brain, lung, placenta and pancreas.
  • 數據庫鏈接:

    HGNC: 3569

    OMIM: 152425

    KEGG: hsa:2180

    STRING: 9606.ENSP00000281455

    UniGene: Hs.406678



主站蜘蛛池模板: 国产乱子伦精品免费无码专区| 成人亚洲欧美激情在线电影| 国产精品久久久久久久久久免费| 亚洲精品无码久久| 日韩成人一区二区三区在线观看| 亚洲国产精品久久久久婷蜜芽| 青青草国产精品一区二区| 天堂在/线中文在线资源 官网| 国产熟妇人妻精品一区二区动漫| 亚洲hdmi高清线| 狠狠色综合激情丁香五月| 少妇的肉体k8经典| 亚洲国产精品第一区二区三区| 又大又粗又长的高潮视频| 日韩人妻无码精品久久久不卡| 亚洲欧美日韩精品色xxx| 免费人成视频网站在线观看18| 亚洲乱亚洲乱妇无码麻豆| 中文字幕精品一区二区2021年| 国产乱色精品成人免费视频| 偷偷做久久久久网站| 亚洲第一天堂无码专区| 最近的中文字幕在线看视频| 成在线人免费无码高潮喷水| 亚洲熟少妇在线播放999| 公与淑婷厨房猛烈进出视频免费| 中文字幕 人妻熟女| 亚洲欧美日韩国产成人| 理论片午午伦夜理片影院| 国产精品久久久久久不卡盗摄| 无套内谢孕妇毛片免费看| 国产成人无码精品久久久免费| 粗大的内捧猛烈进出少妇视频| 97婷婷狠狠成为人免费视频| 搡女人真爽免费视频大全| 中文字日产幕乱五区| 一区一区三区产品乱码亚洲| 天堂中文а√在线官网| 香港三级韩国三级日本三级 | 无码少妇一区二区浪潮av| 久久久久99精品成人片直播|