在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Long-chain-fatty-acid--CoA ligase 1 (ACSL1), partial

  • 中文名稱:
    Recombinant Human Long-chain-fatty-acid--CoA ligase 1(ACSL1),partial
  • 貨號:
    CSB-YP001191HU1
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human Long-chain-fatty-acid--CoA ligase 1(ACSL1),partial
  • 貨號:
    CSB-BP001191HU1
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human Long-chain-fatty-acid--CoA ligase 1(ACSL1),partial
  • 貨號:
    CSB-MP001191HU1
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    ACSL1; FACL1; FACL2; LACS; LACS1; LACS2; Long-chain-fatty-acid--CoA ligase 1; Acyl-CoA synthetase 1; ACS1; Arachidonate--CoA ligase; Long-chain acyl-CoA synthetase 1; LACS 1; Long-chain acyl-CoA synthetase 2; LACS 2; Long-chain fatty acid-CoA ligase 2; Palmitoyl-CoA ligase 1; Palmitoyl-CoA ligase 2; Phytanate--CoA ligase
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate. Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs).
  • 基因功能參考文獻:
    1. These results suggest that ACSL1, ACSL4 and ACSL5 expression is regulated by ER signaling pathways and ACSL5 is a potential novel biomarker for predicting prognosis of breast cancer patients. PMID: 28498416
    2. Study identified a genetic variant in the 3'-UTR region of ACSL1 gene (rs8086) that may play a significant role in predicting outcomes of stage II/III patients with colon cancer, so that patients with T/T genotype had a significantly higher risk of tumor recurrence than those carrying at least one C allele. PMID: 27992526
    3. The mRNA levels of ACSL1 were positively associated with those of HBXIP in clinical breast cancer tissues. Thus, we conclude that the oncoprotein HBXIP is able to up-regulate ACSL1 through activating the transcriptional factor Sp1 in breast cancer. PMID: 28132807
    4. evidence in humans of ACSL1 SNPs associated with fasting glucose, diabetes, and subclinical atherosclerosis PMID: 26711138
    5. SRE motif in ACSL1 is essential for SREBP2-mediated activation of C-ACSL1 gene transcription. PMID: 26728456
    6. ACSL1 is a programmable mediator of insulin sensitivity and cellular lipid content. PMID: 25915184
    7. the cell surface protein CD36/FAT directly facilitates fatty acid transport across the plasma membrane, whereas the intracellular acyl-CoA synthetases FATP4 and ACSL1 enhance fatty acid uptake indirectly by metabolic trapping PMID: 24503477
    8. Data indicate that expression of miR-205 is negatively related to that of ACSL1 in clinical hepatocellular carcinoma (HCC) tissues. PMID: 24462768
    9. long-chain acyl-CoA synthetase 1 has a role in eicosapentaenoic acid suppression of palmitate-induced cytokine production PMID: 23433401
    10. Findings suggest that the ACSL1 gene polymorphism rs6552828 is not associated with elite endurance athletic status in Caucasians, yet a marginal association seems to exist for the Chinese (Han) male population. PMID: 22829935
    11. Data show that ACSL1 rs9997745 polymorphism influences metabolic syndrome risk, most likely via disturbances in fatty acid metabolism, which was modulated by dietary fat consumption, particularly PUFA intake, suggesting novel gene-nutrient interactions. PMID: 20176858
    12. Based on homology, two new isoforms for ACSL1 were predicted and characterized, one represented a switch of the Phe- to the Tyr-Gate domain motif, the other resulted from the exclusion of both. PMID: 16834775

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein.
  • 蛋白家族:
    ATP-dependent AMP-binding enzyme family
  • 組織特異性:
    Highly expressed in liver, heart, skeletal muscle, kidney and erythroid cells, and to a lesser extent in brain, lung, placenta and pancreas.
  • 數據庫鏈接:

    HGNC: 3569

    OMIM: 152425

    KEGG: hsa:2180

    STRING: 9606.ENSP00000281455

    UniGene: Hs.406678



主站蜘蛛池模板: 亚洲无线观看国产精品| 免费国产黄网站在线观看 | 日本熟妇色xxxxx日本免费看 | 四虎精品成人a在线观看| 人妻少妇精品久久久久久| 欧美精品乱码99久久蜜桃| 国产色青青视频在线观看撒| 他掀开裙子把舌头伸进去添视频 | 国产午夜无码片在线观看| 再深点灬舒服灬太大了网站| 免费人成年激情视频在线观看| 亚洲龙腾成小说人网| 亚洲免费视频免在线观看| 日韩精品视频一区二区三区 | 久久99热只有频精品8| 午夜视频在线瓜伦| 欧美交换配乱吟粗大25p| 无码高潮喷吹在线观看 | 夜夜爽日日澡人人添| 浴室人妻的情欲hd三级| 无码超乳爆乳中文字幕久久| 国产午夜福利在线观看视频_| 东京热无码国产精品| 亚洲区日韩精品中文字幕| 亚洲第一网站男人都懂| 强开小婷嫩苞又嫩又紧韩国视频| 亚洲1卡二卡三新区2022| 亚洲精品一区久久久久一品av| 少妇挑战三个黑人惨叫4p国语| а√天堂www在线а√天堂视频| 国产99在线 | 中国| 亚洲色欧美色2019在线| 97久久久人妻一区精品| 97无码免费人妻超级碰碰碰碰| 国产色综合天天综合网| 无尺码精品产品日韩| 国产精品自在自线视频| 蜜臀av999无码精品国产专区 | 产精品视频在线观看免费| 亚洲一卡二卡三卡四卡| 日本不卡不码高清视频|