在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human LIM domain-binding protein 1 (LDB1), partial

  • 中文名稱:
    人LDB1重組蛋白
  • 貨號:
    CSB-YP771433HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人LDB1重組蛋白
  • 貨號:
    CSB-EP771433HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人LDB1重組蛋白
  • 貨號:
    CSB-EP771433HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人LDB1重組蛋白
  • 貨號:
    CSB-BP771433HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人LDB1重組蛋白
  • 貨號:
    CSB-MP771433HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    LDB1
  • Uniprot No.:
  • 別名:
    Carboxyl Terminal LIM Domain Binding 2; Carboxyl-terminal LIM domain-binding protein 2; CLIM 2; CLIM-2; hLdb1; LDB-1; ldb1; LDB1_HUMAN; LIM Domain Binding 1; LIM domain binding factor CLIM2; LIM domain-binding factor CLIM2; LIM domain-binding protein 1; NLI; Nuclear LIM Domain Interactor; Nuclear LIM interactor; xldb1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 表達區域:
    56-285aa
  • 氨基酸序列
    GIGRHTPYGNQTDYRIFELNKRLQNWTEECDNLWWDAFTTEFFEDDAMLTITFCLEDGPKRYTIGRTLIPRYFRSIFEGGATELYYVLKHPKEAFHSNFVSLDCDQGSMVTQHGKPMFTQVCVEGRLYLEFMFDDMMRIKTWHFSIRQHRELIPRSILAMHAQDPQMLDQLSKNITRCGLSNSTLNYLRLCVILEPMQELMSRHKTYSLSPRDCLKTCLFQKWQRMVAPP
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state.
  • 基因功能參考文獻:
    1. Data indicate that LIM-domain-binding protein 1 (LDB1) has a strong role in colorectal cancer (CRC) progression. PMID: 27713177
    2. LDB1 maintains the terminally differentiated state of beta cells and is a component of active enhancers in both murine and human islets. PMID: 27941246
    3. SSBP3 Interacts With Islet-1 and Ldb1 to Impact Pancreatic beta-Cell Target Genes PMID: 26495868
    4. Alanine scanning mutagenesis of the LIM interaction domain of LDB1 revealed a discrete motif, R(320)LITR, required for LMO2 binding. PMID: 26598604
    5. In t(8;21) leukemia cells, LDB1 functions as a component of the stable AML1-ETO-containing transcription factor complex (AETFC). The AETFC components cooperatively regulate gene expression and contribute to leukemogenesis. PMID: 23812588
    6. We investigated NLI (Ldb1 homolog) complex occupancy and chromatin conformation of the beta-globin locus in human erythroid cells. PMID: 22010104
    7. These studies are consistent with a model in which TIF1gamma acts to ubiquitinate LDB1 leading to degradation of LDB1 and changes in transcription of LDB1-dependent promoters. PMID: 20447379
    8. Expression of LDB1 (LIM-domain-binding 1) protein in which Lys134 is replaced with arginine leads to enhanced expression of the mutant protein compared with the wild-type protein. PMID: 20423330
    9. Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to regulate development PMID: 12381786
    10. characterize the assembly of a five-component complex containing TAL1, LMO2, Ldb1, E12, and DNA. The bHLH domains of TAL1 and E12 alone primarily formed helical homodimers, but together formed heterodimers, to which LMO2 bound with high affinity PMID: 17910069

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    LDB family
  • 組織特異性:
    Expressed in a wide range of adult tissues including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, lung and peripheral blood leukocytes.
  • 數據庫鏈接:

    HGNC: 6532

    OMIM: 603451

    KEGG: hsa:8861

    STRING: 9606.ENSP00000392466

    UniGene: Hs.454418



主站蜘蛛池模板: 一日本道a高清免费播放| 亚洲狠狠做深爱婷婷影院| 破了亲妺妺的处免费视频国产| 精品无码一区二区三区的天堂| wwww亚洲熟妇久久久久| 久久人妻无码中文字幕| 国产白丝精品爽爽久久蜜臀| 蜜臀视频一区二区在线播放| 天天躁日日躁狠狠躁性色avq| 亚洲不卡中文字幕无码| 人牛交vide欧美xxxx| 秋霞国产精品一区二区| 亚洲一区二区| 无码熟妇人妻av在线影片| 97精品久久天干天天| 激情综合色综合啪啪五月丁香搜索 | 日本在线视频www鲁啊鲁| 奇米影视第4色| 亚洲国产成人精品青青草原| 国产精品亚洲精品一区二区| 欧美性大战xxxxx久久久√| 欧美精品无码一区二区三区| 亚洲色播爱爱爱爱爱爱爱| av毛片无码中文字幕不卡| 性色欲情网站iwww九文堂| 色噜噜一区二区三区| 99久久久无码国产精品免费| 337p亚洲日本中国大胆69| 亚洲va成无码人在线观看天堂| 国产69精品久久久久999小说| 中文乱码免费一区二区| 最近2019中文字幕在线| 久久久久久久久久久久久9999| 欧美人与物videos另类xxxxx| 精品国产乱码久久久久久下载| 国产亚洲曝欧美不卡精品| 少妇人妻互换不带套| 国产α片免费观看在线人| 日日日日做夜夜夜夜无码| 丁香激情综合久久伊人久久| 自拍区小说区图片区亚洲|