在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Junctional adhesion molecule B (JAM2), partial

  • 中文名稱:
    人JAM2重組蛋白
  • 貨號(hào):
    CSB-EP011936HU
  • 規(guī)格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
  • Uniprot No.:
  • 別名:
    C21orf43; CD 322; CD322; CD322 antigen; JAM 2; JAM B; JAM IT/VE JAM; JAM; vascular endothelial; JAM-2; JAM-B; JAM2; JAM2_HUMAN; JAMB; Jcam2; Junction adhesion molecule 2; Junction adhesion molecule B; Junctional adhesion molecule 2; Junctional adhesion molecule B; PRO 245; PRO245; Vascular endothelial junction associated molecule; Vascular endothelial junction-associated molecule; VE JAM; VE-JAM; VEJAM
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度:
    Extracellular Domain
  • 來源:
    E.coli
  • 分子量:
    27.5kDa
  • 表達(dá)區(qū)域:
    29-238aa
  • 氨基酸序列
    FSAPKDQQVVTAVEYQEAILACKTPKKTVSSRLEWKKLGRSVSFVYYQQTLQGDFKNRAEMIDFNIRIKNVTRSDAGKYRCEVSAPSEQGQNLEEDTVTLEVLVAPAVPSCEVPSSALSGTVVELRCQDKEGNPAPEYTWFKDGIRLLENPRLGSQSTNSSYTMNTKTGTLQFNTVSKLDTGEYSCEARNSVGYRRCPGKRMQVDDLNIS
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM3 to regulate different cellular processes. Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3. Plays a central role in leukocytes extravasation by facilitating not only transmigration but also tethering and rolling of leukocytes along the endothelium. Tethering and rolling of leukocytes are dependent on the binding by JAM2 of the integrin alpha-4/beta-1. Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation. Also functions as an inhibitory somatodendritic cue that prevents the myelination of non-axonal parts of neurons. During myogenesis, it is involved in myocyte fusion. May also play a role in angiogenesis.
  • 基因功能參考文獻(xiàn):
    1. this review briefly focuses on what is currently known about the structure, function, and mechanism of JAM-B, with particular emphasis on cancer. [review] PMID: 27121546
    2. JAM-2 may function as a putative tumour suppressor in the progression and metastasis of colorectal cancer PMID: 26782073
    3. This study showed thatJAM2 (rs2829841; intronic), associated with Alzheimer disease. PMID: 25649652
    4. Function of Jam-B/Jam-C interaction in homing and mobilization of human and mouse hematopoietic stem and progenitor cells. PMID: 24357068
    5. These data brought new evidences for the role of JAM2 and JAM3 in progression of gastric adenocarcinoma PMID: 23277282
    6. role as an adhesive ligand for interacting with a variety of immune cell types PMID: 11823489
    7. interacts with alpha4beta1; Facilitation by JAM3 PMID: 12070135
    8. Results suggest a role for junctional adhesion molecule-2 (JAM-2) in facilitating transmigration in endothelial cells PMID: 12476045
    9. Examine JAM-2 expression in normal/inflammed lymphatic endothelium. PMID: 17822725
    10. Discovery as ligand for the integrin alpha4beta1 PMID: 12070135
    11. Cloning and discovery as adhesion receptor for T cells PMID: 10945976

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell membrane; Single-pass type I membrane protein. Cell junction. Cell junction, tight junction.
  • 蛋白家族:
    Immunoglobulin superfamily
  • 組織特異性:
    Highly expressed in heart, placenta, lung, foreskin and lymph node. Prominently expressed on high endothelial venules and also present on the endothelia of other vessels (at protein level). Also expressed in the brain in the caudate nuclei.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 14686

    OMIM: 606870

    KEGG: hsa:58494

    STRING: 9606.ENSP00000420419

    UniGene: Hs.517227



主站蜘蛛池模板: 亚洲中文字幕码在线电影| 中文字幕乱码免费看电影| 337p西西人体大胆瓣开下部| 国产无套粉嫩白浆在线| 久久亚洲欧美国产精品| 国产福利在线永久视频| 午夜免费男女aaaa片| 日韩精品久久无码中文字幕| 男人扒开添女人下部免费视频| 色欲天天网站欧美成人福利网| 亚洲sm另类一区二区三区| 国产精品久久久久久久久久| 欧美激情精品久久| 亚洲国产成人精品青青草原| 欧美成人aaaa免费全部观看| 久久久国产一区二区三区| 少妇人妻偷人精品视蜜桃| 精品久久久久久无码国产| 亚洲欧美日韩国产另类电影| 国产牛仔裤网站精品| 亚洲第一无码精品立川理惠| 四虎影视国产精品久久| 日本wv一本一道久久香蕉| 天堂…中文在线最新版在线| 色先锋av资源中文字幕| 亚洲人成网站在线播放小说| 久久99er6热线精品首页| 久久久久麻豆v国产精华液好用吗| 麻豆精产国品| 亚洲午夜理论片在线观看| 国产成av人片在线观看无码| 久久综合九色综合欧美98 | 狠狠躁天天躁夜夜躁婷婷| 强行交换配乱婬bd| 国产在线无码视频一区二区三区| 少妇高潮太爽了在线视频| 无尺码精品产品日韩| 非洲黑人性xxxx精品| 国产精品白浆无码流出视频| 精品夜夜澡人妻无码av蜜桃| 人妻av无码系列专区移动可看|