在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Junctional adhesion molecule B (JAM2), partial

  • 中文名稱:
    人JAM2 C21orf43 VEJAM UNQ219/PRO245重組蛋白
  • 貨號:
    CSB-BP011936HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人JAM2 C21orf43 VEJAM UNQ219/PRO245重組蛋白
  • 貨號:
    CSB-EP011936HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人JAM2 C21orf43 VEJAM UNQ219/PRO245重組蛋白
  • 貨號:
    CSB-MP011936HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    JAM2 C21orf43 VEJAM UNQ219/PRO245
  • Uniprot No.:
  • 別名:
    C21orf43; CD 322; CD322; CD322 antigen; JAM 2; JAM B; JAM IT/VE JAM; JAM; vascular endothelial; JAM-2; JAM-B; JAM2; JAM2_HUMAN; JAMB; Jcam2; Junction adhesion molecule 2; Junction adhesion molecule B; Junctional adhesion molecule 2; Junctional adhesion molecule B; PRO 245; PRO245; Vascular endothelial junction associated molecule; Vascular endothelial junction-associated molecule; VE JAM; VE-JAM; VEJAM
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 表達區域:
    29-238aa
  • 氨基酸序列
    FSAPKDQQVVTAVEYQEAILACKTPKKTVSSRLEWKKLGRSVSFVYYQQTLQGDFKNRAEMIDFNIRIKNVTRSDAGKYRCEVSAPSEQGQNLEEDTVTLEVLVAPAVPSCEVPSSALSGTVVELRCQDKEGNPAPEYTWFKDGIRLLENPRLGSQSTNSSYTMNTKTGTLQFNTVSKLDTGEYSCEARNSVGYRRCPGKRMQVDDLNIS
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM3 to regulate different cellular processes. Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3. Plays a central role in leukocytes extravasation by facilitating not only transmigration but also tethering and rolling of leukocytes along the endothelium. Tethering and rolling of leukocytes are dependent on the binding by JAM2 of the integrin alpha-4/beta-1. Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation. Also functions as an inhibitory somatodendritic cue that prevents the myelination of non-axonal parts of neurons. During myogenesis, it is involved in myocyte fusion. May also play a role in angiogenesis.
  • 基因功能參考文獻:
    1. this review briefly focuses on what is currently known about the structure, function, and mechanism of JAM-B, with particular emphasis on cancer. [review] PMID: 27121546
    2. JAM-2 may function as a putative tumour suppressor in the progression and metastasis of colorectal cancer PMID: 26782073
    3. This study showed thatJAM2 (rs2829841; intronic), associated with Alzheimer disease. PMID: 25649652
    4. Function of Jam-B/Jam-C interaction in homing and mobilization of human and mouse hematopoietic stem and progenitor cells. PMID: 24357068
    5. These data brought new evidences for the role of JAM2 and JAM3 in progression of gastric adenocarcinoma PMID: 23277282
    6. role as an adhesive ligand for interacting with a variety of immune cell types PMID: 11823489
    7. interacts with alpha4beta1; Facilitation by JAM3 PMID: 12070135
    8. Results suggest a role for junctional adhesion molecule-2 (JAM-2) in facilitating transmigration in endothelial cells PMID: 12476045
    9. Examine JAM-2 expression in normal/inflammed lymphatic endothelium. PMID: 17822725
    10. Discovery as ligand for the integrin alpha4beta1 PMID: 12070135
    11. Cloning and discovery as adhesion receptor for T cells PMID: 10945976

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein. Cell junction. Cell junction, tight junction.
  • 蛋白家族:
    Immunoglobulin superfamily
  • 組織特異性:
    Highly expressed in heart, placenta, lung, foreskin and lymph node. Prominently expressed on high endothelial venules and also present on the endothelia of other vessels (at protein level). Also expressed in the brain in the caudate nuclei.
  • 數據庫鏈接:

    HGNC: 14686

    OMIM: 606870

    KEGG: hsa:58494

    STRING: 9606.ENSP00000420419

    UniGene: Hs.517227



主站蜘蛛池模板: 天天摸日日摸爽爽狠狠| 2020无码天天喷水天天爽| 欧美怡红院免费全部视频| 无码国产伦一区二区三区视频| r级无码视频在线观看| 自慰系列无码专区| 欧美午夜片欧美片在线观看| 老湿机香蕉久久久久久| 免费国产裸体美女视频全黄| 欧美三级韩国三级日本三斤| 国产精品久久久久久久久岛| 麻豆国产人妻欲求不满| 潮喷大喷水系列无码久久精品| 亚洲国产欧美在线人成| 性生交大片免费看女人按摩| 九九视频在线观看视频6 | 成人网站国产在线视频内射视频| 日韩在线不卡免费视频一区| 国产麻豆成人传媒免费观看| 亚洲乱亚洲乱妇中文影视| 国产做爰xxxⅹ久久久小说| 麻豆果冻传媒2021精品传媒一区下载| 熟妇人妻一区二区三区四区| 免费人成视频在线| 超碰曰口干天天种夜夜爽| 精品午夜中文字幕熟女人妻在线 | 亚洲另类成人小说综合网| 久久欧美一区二区三区性牲奴| 国产 亚洲 制服 无码 中文| 久久久成人毛片无码| 国产精品三级一区二区| 国产免费久久久久久无码| 中文字幕乱码人在线视频1区| 婷婷色婷婷开心五月四房播播久久| 国产精品美女久久久网站 | 亚洲乱码中文字幕在线| 久久综合伊人九色综合| 日产2021免费一区| 国产一区日韩二区欧美三区| 少妇愉情理伦片高潮日本| 久久精品国产亚洲欧美成人|