在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Grainyhead-like protein 1 homolog (GRHL1)

  • 中文名稱:
    人GRHL1重組蛋白
  • 貨號:
    CSB-YP868368HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人GRHL1重組蛋白
  • 貨號:
    CSB-EP868368HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人GRHL1重組蛋白
  • 貨號:
    CSB-EP868368HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人GRHL1重組蛋白
  • 貨號:
    CSB-BP868368HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人GRHL1重組蛋白
  • 貨號:
    CSB-MP868368HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    GRHL1
  • Uniprot No.:
  • 別名:
    Grainyhead-like protein 1 homolog; grhl1; GRHL1_HUMAN; LBP32; Mammalian grainyhead; MGR; NH32; TFCP2L2; Transcription factor CP2-like 2; Transcription factor LBP-32
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-618
  • 氨基酸序列
    MTQEYDNKRP VLVLQNEALY PQRRSYTSED EAWKSFLENP LTAATKAMMS INGDEDSAAA LGLLYDYYKV PRERRSSTAK PEVEHPEPDH SKRNSIPIVT EQPLISAGEN RVQVLKNVPF NIVLPHGNQL GIDKRGHLTA PDTTVTVSIA TMPTHSIKTE TQPHGFAVGI PPAVYHPEPT ERVVVFDRNL NTDQFSSGAQ APNAQRRTPD STFSETFKEG VQEVFFPSDL SLRMPGMNSE DYVFDSVSGN NFEYTLEASK SLRQKPGDST MTYLNKGQFY PITLKEVSSS EGIHHPISKV RSVIMVVFAE DKSREDQLRH WKYWHSRQHT AKQRCIDIAD YKESFNTISN IEEIAYNAIS FTWDINDEAK VFISVNCLST DFSSQKGVKG LPLNIQVDTY SYNNRSNKPV HRAYCQIKVF CDKGAERKIR DEERKQSKRK VSDVKVPLLP SHKRMDITVF KPFIDLDTQP VLFIPDVHFA NLQRGTHVLP IASEELEGEG SVLKRGPYGT EDDFAVPPST KLARIEEPKR VLLYVRKESE EVFDALMLKT PSLKGLMEAI SDKYDVPHDK IGKIFKKCKK GILVNMDDNI VKHYSNEDTF QLQIEEAGGS YKLTLTEI
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3'. Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development.; Functions as transcription activator.; May function as a repressor in tissues where both isoform 1 and isoform 2 are expressed.
  • 基因功能參考文獻:
    1. Non-melanoma skin cancer growth is accompanied by coordinated reduced expression of epidermal differentiation genes: GRHL1 and GRHL3, which may be regulated by miR-21-3p and -5p, respectively. Some potentially damaging single nucleotide polymorphisms in GRHL genes occur with altered frequencies in NMSC patients, and they may in particular impair the expression of GRHL3 gene or functioning of encoded protein PMID: 29301499
    2. All of these processes involve epithelial-mesencyhmal transition (EMT), MET or a sequence of both, suggesting that the GRHL factors((GRHL1, GRHL2 and GRHL3), could potentially affect tumor initiation and progression via EMT PMID: 28714958
    3. it was observed that ER stimulated gene expression by interacting with MEIS1 and FOXP3, and ER inhibited gene expression by interacting with THRB and GRHL1. PMID: 27035558
    4. Grhl1 deficiency affects inner ear development in zebrafish. PMID: 25896282
    5. GRHL1, GRHL2, and GRHL3 have roles in cellular proliferation, differentiation, adhesion, and polarity and may promote cancer or be tumor suppressors [review] PMID: 26069269
    6. Downregulation of miR122 by grainyhead-like 2 restricts the hepatocytic differentiation potential of adult liver progenitor cells. PMID: 25406394
    7. A significant role for HDAC3 in the MYCN-mediated repression of GRHL1. PMID: 24419085
    8. Our findings reveal important pathophysiological differences between human pulmonary fibrosis and specific mouse models of fibrosis and support a crucial role of GRHL2 in epithelial activation in lung fibrosis and perhaps also in epithelial plasticity. PMID: 24375798
    9. LBP-1b and LBP-9 both stimulate LBP-32/MGR promoter activity. PMID: 18004979
    10. Includes a comparison to TFCP2L2, the GRHL1 protein. PMID: 12393799

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Grh/CP2 family, Grainyhead subfamily
  • 組織特異性:
    Isoform 1 is highly expressed in brain, pancreas, tonsil, placenta and kidney. Isoform 2 is highly expressed in brain and liver. Expressed at very low levels in non-steroidogenic cells.
  • 數據庫鏈接:

    HGNC: 17923

    OMIM: 609786

    KEGG: hsa:29841

    STRING: 9606.ENSP00000324693

    UniGene: Hs.418493



主站蜘蛛池模板: 少妇高清精品毛片在线视频| 精品无码一区二区三区av| 免费看成人aa片无码视频羞羞网| 苍井空亚洲精品aa片在线播放| 中文字幕无码日韩专区| 欧美肥臀大屁股magnet| 激情内射亚洲一区二区三区| 99久久无码一区人妻| 久艹视频免费看| 少妇无码av无码一区| 中国丰满少妇人妻xxx性董鑫洁 | 女人大荫蒂毛茸茸视频| 国内精品视频自在一区| a∨在线视频播放| 日本高清色倩视频在线观看| 中国国语毛片免费观看视频| 中文字幕乱码一区二区三区免费| 人妻少妇无码中文幕久久| 国产精品免费福利久久| aa片在线观看视频在线播放| 中文无码精品a∨在线观看| 人妻无码熟妇乱又伦精品视频| 精品成在人线av无码免费看| 2018av天堂在线视频精品观看| 国产女精品视频网站免费| 国产在线精品一品二区| 成年女人永久免费观看视频| 樱花草在线社区www韩国| 又大又粗又爽免费视频a片| 人妻激情文学| 熟妇丰满多毛的大隂户| 亚洲综合色婷婷六月丁香宅男大增 | 亚洲精品成a人在线观看| 午夜福利国产成人无码gif动图| 久久久久久无码日韩欧美| 好紧好湿好黄的视频| 精品久久人人妻人人做精品| 亚洲综合日韩久久成人av| 国产无套粉嫩白浆在线观看| 精品国产一区二区三区四区阿崩| 亚洲国产一区二区三区在观看|