在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GRHL1 Antibody, FITC conjugated

  • 中文名稱:
    GRHL1兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA868368LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) GRHL1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    GRHL1
  • 別名:
    Grainyhead-like protein 1 homolog antibody; grhl1 antibody; GRHL1_HUMAN antibody; LBP32 antibody; Mammalian grainyhead antibody; MGR antibody; NH32 antibody; TFCP2L2 antibody; Transcription factor CP2-like 2 antibody; Transcription factor LBP-32 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Grainyhead-like protein 1 homologprotein (1-95AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3'. Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development.; Functions as transcription activator.; May function as a repressor in tissues where both isoform 1 and isoform 2 are expressed.
  • 基因功能參考文獻:
    1. Non-melanoma skin cancer growth is accompanied by coordinated reduced expression of epidermal differentiation genes: GRHL1 and GRHL3, which may be regulated by miR-21-3p and -5p, respectively. Some potentially damaging single nucleotide polymorphisms in GRHL genes occur with altered frequencies in NMSC patients, and they may in particular impair the expression of GRHL3 gene or functioning of encoded protein PMID: 29301499
    2. All of these processes involve epithelial-mesencyhmal transition (EMT), MET or a sequence of both, suggesting that the GRHL factors((GRHL1, GRHL2 and GRHL3), could potentially affect tumor initiation and progression via EMT PMID: 28714958
    3. it was observed that ER stimulated gene expression by interacting with MEIS1 and FOXP3, and ER inhibited gene expression by interacting with THRB and GRHL1. PMID: 27035558
    4. Grhl1 deficiency affects inner ear development in zebrafish. PMID: 25896282
    5. GRHL1, GRHL2, and GRHL3 have roles in cellular proliferation, differentiation, adhesion, and polarity and may promote cancer or be tumor suppressors [review] PMID: 26069269
    6. Downregulation of miR122 by grainyhead-like 2 restricts the hepatocytic differentiation potential of adult liver progenitor cells. PMID: 25406394
    7. A significant role for HDAC3 in the MYCN-mediated repression of GRHL1. PMID: 24419085
    8. Our findings reveal important pathophysiological differences between human pulmonary fibrosis and specific mouse models of fibrosis and support a crucial role of GRHL2 in epithelial activation in lung fibrosis and perhaps also in epithelial plasticity. PMID: 24375798
    9. LBP-1b and LBP-9 both stimulate LBP-32/MGR promoter activity. PMID: 18004979
    10. Includes a comparison to TFCP2L2, the GRHL1 protein. PMID: 12393799

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Grh/CP2 family, Grainyhead subfamily
  • 組織特異性:
    Isoform 1 is highly expressed in brain, pancreas, tonsil, placenta and kidney. Isoform 2 is highly expressed in brain and liver. Expressed at very low levels in non-steroidogenic cells.
  • 數據庫鏈接:

    HGNC: 17923

    OMIM: 609786

    KEGG: hsa:29841

    STRING: 9606.ENSP00000324693

    UniGene: Hs.418493



主站蜘蛛池模板: 国产老熟女狂叫对白| 女同性av片在线观看免费网站| 国产末成年av在线播放| 国产精品欧美久久久久无广告| 护士人妻hd中文字幕| 97精品人妻一区二区三区香蕉| 丁香五月亚洲综合深深爱| 亚洲手机在线人成网站| 无码视频在线观看| 一卡二卡三卡视频| 国产成人无码18禁午夜福利网址| 亚洲深深色噜噜狠狠网站| 妺妺窝人体色www看人体| 成年女人a毛片免费视频| 中文 在线 日韩 亚洲 欧美| 视频二区丝袜国产欧美日韩| 国产成人精品久久| 青娱乐极品视觉盛宴av | 久久永久免费专区人妻精品| 无码日韩精品一区二区三区免费| 久久精品国产导航| 国产香港明星裸体xxxx视频| 2019精品国自产拍在线不卡| 五月婷婷久久草丁香| 久热在线中文字幕色999舞| 四虎永久在线精品免费观看视频| 嫩草研究院久久久精品| 精品人妻av区| 成人精品一区二区三区电影免费| 在线看片免费人成视频国产片| 苍井空一区二区波多野结衣av| 99国产欧美久久久精品蜜芽| 久久精品国产久精国产果冻传媒| 吃奶呻吟张开双腿做受在线播放| 成人免费777777被爆出| 玩弄放荡人妇系列av在线网站| 日韩亚洲国产中文永久| 精品国产人成亚洲区| 成人国产网站v片免费观看| 精品无码成人网站久久久久久| 亚洲国产果冻传媒av在线观看|