在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. GRHL1 Antibody

GRHL1 Antibody

  • 中文名稱：
    GRHL1兔多克隆抗體
  • 貨號：
    CSB-PA868368LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, HepG2 whole cell lysate, A549 whole cell lysate
      All lanes: GRHL1 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 71, 50, 58 kDa
      Observed band size: 71 kDa
    • IHC image of CSB-PA868368LA01HU diluted at 1:300 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA868368LA01HU diluted at 1:300 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) GRHL1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    GRHL1
  • 別名：
    Grainyhead-like protein 1 homolog antibody; grhl1 antibody; GRHL1_HUMAN antibody; LBP32 antibody; Mammalian grainyhead antibody; MGR antibody; NH32 antibody; TFCP2L2 antibody; Transcription factor CP2-like 2 antibody; Transcription factor LBP-32 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Grainyhead-like protein 1 homologprotein (1-95AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，GRHL1 Antibody (CSB-PA868368LA01HU)，的標記方式是Non-conjugated。對于GRHL1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA868368LB01HU GRHL1 Antibody, HRP conjugated ELISA
    FITC CSB-PA868368LC01HU GRHL1 Antibody, FITC conjugated
    Biotin CSB-PA868368LD01HU GRHL1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3'. Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development.; Functions as transcription activator.; May function as a repressor in tissues where both isoform 1 and isoform 2 are expressed.
  • 基因功能參考文獻：
    1. Non-melanoma skin cancer growth is accompanied by coordinated reduced expression of epidermal differentiation genes: GRHL1 and GRHL3, which may be regulated by miR-21-3p and -5p, respectively. Some potentially damaging single nucleotide polymorphisms in GRHL genes occur with altered frequencies in NMSC patients, and they may in particular impair the expression of GRHL3 gene or functioning of encoded protein PMID: 29301499
    2. All of these processes involve epithelial-mesencyhmal transition (EMT), MET or a sequence of both, suggesting that the GRHL factors((GRHL1, GRHL2 and GRHL3), could potentially affect tumor initiation and progression via EMT PMID: 28714958
    3. it was observed that ER stimulated gene expression by interacting with MEIS1 and FOXP3, and ER inhibited gene expression by interacting with THRB and GRHL1. PMID: 27035558
    4. Grhl1 deficiency affects inner ear development in zebrafish. PMID: 25896282
    5. GRHL1, GRHL2, and GRHL3 have roles in cellular proliferation, differentiation, adhesion, and polarity and may promote cancer or be tumor suppressors [review] PMID: 26069269
    6. Downregulation of miR122 by grainyhead-like 2 restricts the hepatocytic differentiation potential of adult liver progenitor cells. PMID: 25406394
    7. A significant role for HDAC3 in the MYCN-mediated repression of GRHL1. PMID: 24419085
    8. Our findings reveal important pathophysiological differences between human pulmonary fibrosis and specific mouse models of fibrosis and support a crucial role of GRHL2 in epithelial activation in lung fibrosis and perhaps also in epithelial plasticity. PMID: 24375798
    9. LBP-1b and LBP-9 both stimulate LBP-32/MGR promoter activity. PMID: 18004979
    10. Includes a comparison to TFCP2L2, the GRHL1 protein. PMID: 12393799

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Grh/CP2 family, Grainyhead subfamily
  • 組織特異性：
    Isoform 1 is highly expressed in brain, pancreas, tonsil, placenta and kidney. Isoform 2 is highly expressed in brain and liver. Expressed at very low levels in non-steroidogenic cells.
  • 數據庫鏈接：

    HGNC: 17923

    OMIM: 609786

    KEGG: hsa:29841

    STRING: 9606.ENSP00000324693

    UniGene: Hs.418493



主站蜘蛛池模板： 成在人线av无码免费漫画| 国产亚洲精品美女久久久久| 色偷一区国产精品| 亚洲精品无码专区在线观看| 无码av喷白浆在线播放| 精品久久久无码中文字幕| 欧美精品久久久久久久自慰| 日本狂喷奶水在线播放212| 人人妻人人爽日日人人| 激情爆乳一区二区三区| 色婷婷日日躁夜夜躁| 午夜亚洲乱码伦小说区69堂| av在线播放日韩亚洲欧我不卡 | 少妇人妻精品一区二区| 日产日韩亚洲欧美综合在线| 玖玖资源站无码专区| 无码丰满熟妇juliaann与黑人| 中文字幕日韩一区二区不卡| 亚洲欧洲日产国码无码av一| 久久亚洲精品无码播放 | 欧美伊人色综合久久天天| 国内精品九九久久精品| 内射夜晚在线观看| 欧美丰满大乳高跟鞋| 成年入口无限观看免费完整大片| 日本免费一区二区三区最新| 国产区又黄又硬高潮的视频| 99久久精品6在线播放| 国产超碰人人做人人爱ⅴa| 麻豆国产精品va在线观看| 中文字幕免费无码专区| 亚洲中文字幕无码不卡电影| 天堂国产一区二区三区| 久久综合色_综合色88| 被黑人猛躁10次高潮视频| 国产在线观看码高清视频| 国产白嫩护士在线播放| 人妻av无码中文专区久久 | 久久久www成人免费精品| 激情97综合亚洲色婷婷五| 久久久久久久久蜜桃|