在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GRHL1 Antibody, HRP conjugated

  • 中文名稱:
    GRHL1兔多克隆抗體, HRP偶聯(lián)
  • 貨號:
    CSB-PA868368LB01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) GRHL1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    GRHL1
  • 別名:
    Grainyhead-like protein 1 homolog antibody; grhl1 antibody; GRHL1_HUMAN antibody; LBP32 antibody; Mammalian grainyhead antibody; MGR antibody; NH32 antibody; TFCP2L2 antibody; Transcription factor CP2-like 2 antibody; Transcription factor LBP-32 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Grainyhead-like protein 1 homologprotein (1-95AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3'. Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development.; Functions as transcription activator.; May function as a repressor in tissues where both isoform 1 and isoform 2 are expressed.
  • 基因功能參考文獻:
    1. Non-melanoma skin cancer growth is accompanied by coordinated reduced expression of epidermal differentiation genes: GRHL1 and GRHL3, which may be regulated by miR-21-3p and -5p, respectively. Some potentially damaging single nucleotide polymorphisms in GRHL genes occur with altered frequencies in NMSC patients, and they may in particular impair the expression of GRHL3 gene or functioning of encoded protein PMID: 29301499
    2. All of these processes involve epithelial-mesencyhmal transition (EMT), MET or a sequence of both, suggesting that the GRHL factors((GRHL1, GRHL2 and GRHL3), could potentially affect tumor initiation and progression via EMT PMID: 28714958
    3. it was observed that ER stimulated gene expression by interacting with MEIS1 and FOXP3, and ER inhibited gene expression by interacting with THRB and GRHL1. PMID: 27035558
    4. Grhl1 deficiency affects inner ear development in zebrafish. PMID: 25896282
    5. GRHL1, GRHL2, and GRHL3 have roles in cellular proliferation, differentiation, adhesion, and polarity and may promote cancer or be tumor suppressors [review] PMID: 26069269
    6. Downregulation of miR122 by grainyhead-like 2 restricts the hepatocytic differentiation potential of adult liver progenitor cells. PMID: 25406394
    7. A significant role for HDAC3 in the MYCN-mediated repression of GRHL1. PMID: 24419085
    8. Our findings reveal important pathophysiological differences between human pulmonary fibrosis and specific mouse models of fibrosis and support a crucial role of GRHL2 in epithelial activation in lung fibrosis and perhaps also in epithelial plasticity. PMID: 24375798
    9. LBP-1b and LBP-9 both stimulate LBP-32/MGR promoter activity. PMID: 18004979
    10. Includes a comparison to TFCP2L2, the GRHL1 protein. PMID: 12393799

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Grh/CP2 family, Grainyhead subfamily
  • 組織特異性:
    Isoform 1 is highly expressed in brain, pancreas, tonsil, placenta and kidney. Isoform 2 is highly expressed in brain and liver. Expressed at very low levels in non-steroidogenic cells.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 17923

    OMIM: 609786

    KEGG: hsa:29841

    STRING: 9606.ENSP00000324693

    UniGene: Hs.418493



主站蜘蛛池模板: 精品一区二区三区无码视频| 国产精品夜间视频香蕉| 国产韩国精品一区二区三区久久| 东北妇女精品bbwbbw| 欧美性猛交xxxx黑人| 青青国产揄拍视频| 四虎永久在线精品免费网址| 日韩精品无码中文字幕一区二区| 大香伊蕉在人线免费视频| 精品日韩亚洲欧美高清a| 在线天堂资源www| 久久中文字幕无码专区| 国产免费艾彩sm调教视频 | 亚洲熟妇无码爱v在线观看| 亚洲日韩精品无码专区| av无码精品一区二区三区宅噜噜| 99视频精品全部免费 在线| 国产精品女上位好爽在线| 国产乱子伦精品免费视频| 国产精品视频免费一区二区| 熟妇人妻中文字幕无码老熟妇 | 寂寞少妇做spa按摩无码| 99久久无色码中文字幕| 香蕉久久av一区二区三区app| 真实国产乱子伦在线视频| 最近日本免费观看高清视频 | 免费人成视频x8x8入口| 久久精品国产亚洲一区二区| 无码少妇一区二区浪潮免费| 午夜内射中出视频| 国产高清在线a免费视频观看| 日本猛少妇色xxxxx猛叫| 国产精品视频免费播放| 东京热人妻无码一区二区av| 爆乳护士一区二区三区在线播放| 成人无码视频免费播放| 国产农村老太xxxxhdxx| 久久人人爽人人爽人人片av麻烦| 饥渴少妇做私密保健视频| 国产一区二区三区不卡在线看| 一区二区三区内射美女毛片|