在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GRHL1 Antibody, HRP conjugated

  • 中文名稱:
    GRHL1兔多克隆抗體, HRP偶聯(lián)
  • 貨號:
    CSB-PA868368LB01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) GRHL1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    GRHL1
  • 別名:
    Grainyhead-like protein 1 homolog antibody; grhl1 antibody; GRHL1_HUMAN antibody; LBP32 antibody; Mammalian grainyhead antibody; MGR antibody; NH32 antibody; TFCP2L2 antibody; Transcription factor CP2-like 2 antibody; Transcription factor LBP-32 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Grainyhead-like protein 1 homologprotein (1-95AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3'. Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development.; Functions as transcription activator.; May function as a repressor in tissues where both isoform 1 and isoform 2 are expressed.
  • 基因功能參考文獻:
    1. Non-melanoma skin cancer growth is accompanied by coordinated reduced expression of epidermal differentiation genes: GRHL1 and GRHL3, which may be regulated by miR-21-3p and -5p, respectively. Some potentially damaging single nucleotide polymorphisms in GRHL genes occur with altered frequencies in NMSC patients, and they may in particular impair the expression of GRHL3 gene or functioning of encoded protein PMID: 29301499
    2. All of these processes involve epithelial-mesencyhmal transition (EMT), MET or a sequence of both, suggesting that the GRHL factors((GRHL1, GRHL2 and GRHL3), could potentially affect tumor initiation and progression via EMT PMID: 28714958
    3. it was observed that ER stimulated gene expression by interacting with MEIS1 and FOXP3, and ER inhibited gene expression by interacting with THRB and GRHL1. PMID: 27035558
    4. Grhl1 deficiency affects inner ear development in zebrafish. PMID: 25896282
    5. GRHL1, GRHL2, and GRHL3 have roles in cellular proliferation, differentiation, adhesion, and polarity and may promote cancer or be tumor suppressors [review] PMID: 26069269
    6. Downregulation of miR122 by grainyhead-like 2 restricts the hepatocytic differentiation potential of adult liver progenitor cells. PMID: 25406394
    7. A significant role for HDAC3 in the MYCN-mediated repression of GRHL1. PMID: 24419085
    8. Our findings reveal important pathophysiological differences between human pulmonary fibrosis and specific mouse models of fibrosis and support a crucial role of GRHL2 in epithelial activation in lung fibrosis and perhaps also in epithelial plasticity. PMID: 24375798
    9. LBP-1b and LBP-9 both stimulate LBP-32/MGR promoter activity. PMID: 18004979
    10. Includes a comparison to TFCP2L2, the GRHL1 protein. PMID: 12393799

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Grh/CP2 family, Grainyhead subfamily
  • 組織特異性:
    Isoform 1 is highly expressed in brain, pancreas, tonsil, placenta and kidney. Isoform 2 is highly expressed in brain and liver. Expressed at very low levels in non-steroidogenic cells.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 17923

    OMIM: 609786

    KEGG: hsa:29841

    STRING: 9606.ENSP00000324693

    UniGene: Hs.418493



主站蜘蛛池模板: 97精品尹人久久大香线蕉| 免费国产白丝喷水娇喘视频| 春药高潮抽搐流白浆在线观看| 国产成人亚洲精品无码车a| 国产美女遭强高潮网站下载| 在线 | 一区二区三区四区| 天堂中文最新版在线中文 | 国产亚洲精品久久久久久青梅| 亚洲午夜精品a片久久www慈禧| 国产超薄肉色丝袜视频| 亚洲欧美日韩综合一区在线| 熟女乱亚洲图| 午夜福利视频| 久久亚洲精品成人av无码网站| 亚洲a成人无m网站在线| 裸体女人高潮毛片| 国产亚洲精品美女久久久| 人妻色综合网站| 国产精品久久久久久成人影院| 亚洲视频高清不卡在线观看| 色五月丁香六月欧美综合| 国内精品自在自线| 成人性生交大片免费看小说| 日本视频免费高清一本18| 97人摸人人澡人人人超碰| 野外少妇愉情中文字幕| 性夜夜春夜夜爽aa片a| 人妻夜夜爽天天爽一区| 久久好在线视频| 在线观看特色大片免费网站| 亚洲国产精品国语在线| 久久亚洲人成电影网| 日韩亚洲国产激情一区浪潮av| 国产成人精品视频一区二区不卡| 亚洲欧美日韩国产综合v| 精产国品一二三产品麻豆 | 无码乱人伦一区二区亚洲一| 久久精品国产久精国产一老狼| 秋霞国产精品一区二区| 漂亮人妻洗澡被公强 日日躁| 国模冰莲极品自慰人体|