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  4. Recombinant Human Glutamate dehydrogenase 2, mitochondrial (GLUD2)

Recombinant Human Glutamate dehydrogenase 2, mitochondrial (GLUD2)

  • 中文名稱：
    人GLUD2重組蛋白
  • 貨號：
    CSB-YP009545HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人GLUD2重組蛋白
  • 貨號：
    CSB-EP009545HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人GLUD2重組蛋白
  • 貨號：
    CSB-EP009545HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人GLUD2重組蛋白
  • 貨號：
    CSB-BP009545HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人GLUD2重組蛋白
  • 貨號：
    CSB-MP009545HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    DHE4_HUMAN; GDH 2; GDH; GDH2; GLUD2; GLUDP1; Glutamate dehydrogenase 2; Glutamate dehydrogenase 2 mitochondrial; Glutamate dehydrogenase pseudogene 1; mitochondrial
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    54-558
  • 氨基酸序列
    SELVADR EDDPNFFKMV EGFFDRGASI VEDKLVKDLR TQESEEQKRN RVRGILRIIK PCNHVLSLSF PIRRDDGSWE VIEGYRAQHS QHRTPCKGGI RYSTDVSVDE VKALASLMTY KCAVVDVPFG GAKAGVKINP KNYTENELEK ITRRFTMELA KKGFIGPGVD VPAPDMNTGE REMSWIADTY ASTIGHYDIN AHACVTGKPI SQGGIHGRIS ATGRGVFHGI ENFINEASYM SILGMTPGFR DKTFVVQGFG NVGLHSMRYL HRFGAKCIAV GESDGSIWNP DGIDPKELED FKLQHGSILG FPKAKPYEGS ILEVDCDILI PAATEKQLTK SNAPRVKAKI IAEGANGPTT PEADKIFLER NILVIPDLYL NAGGVTVSYF EWLKNLNHVS YGRLTFKYER DSNYHLLLSV QESLERKFGK HGGTIPIVPT AEFQDSISGA SEKDIVHSAL AYTMERSARQ IMHTAMKYNL GLDLRTAAYV NAIEKVFKVY SEAGVTFT
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission.
  • 基因功能參考文獻：
    1. hGDH2 evolution bestowed large human neurons with enhanced glutamate metabolizing capacity, thus strengthening cortical excitatory transmission. PMID: 26399640
    2. This study demonstrated that hGDH2 expression increases capacity for uptake and oxidative metabolism of glutamate, particularly during increased workload and hypoglycemia. PMID: 28032919
    3. This proliferation requires glutamate dehydrogenase 2, which synthesizes glutamate from ammonia and alpha-ketoglutarate and is expressed in MCF7 and T47D cells. Our findings provide insight into how cancer cells survive under glutamine deprivation conditions and thus contribute to elucidating the mechanisms of tumor growth. PMID: 29146184
    4. The expression of GLUD2 was identified in the cellular and subcellular compartments of numerous tissues. PMID: 27422263
    5. Notably, the introduction of GLUD2 did not affect glutamate levels in mice, consistent with observations in the primates. Instead, the metabolic effects of GLUD2 center on the tricarboxylic acid cycle, suggesting that GLUD2 affects carbon flux during early brain development, possibly supporting lipid biosynthesis. PMID: 27118840
    6. IDH1(R132H) exhibits a growth-inhibitory effect that is abrogated in the presence of glutamate dehydrogenase 2 (GLUD2), a hominoid-specific enzyme purportedly optimized to facilitate glutamate turnover in human forebrain. PMID: 25225364
    7. hGDH2 can operate efficiently in the relatively acidic environment that prevails in astrocytes following glutamate uptake [review] PMID: 24352816
    8. [review] Whereas GDH2 in most mammals is encoded by a single functional GLUD1 gene expressed widely, humans have acquired through retroposition an X-linked GLUD2 gene that encodes a highly homologous isoenzyme GDH2 expressed in testis and brain. PMID: 21420458
    9. GLUD2 glutamate dehydrogenase is expressed in neural and testicular supporting cells PMID: 20194501
    10. A gain-of-function rare polymorphism in hGDH2 hastens the onset of Parkinson's disease in hemizygous subjects. PMID: 19826450
    11. amino acid changes, acting in concert with Arg443Ser and Gly456Ala, ought to be responsible the unique properties of the brain-specific human isoenzyme PMID: 17924438
    12. Mitochondrial targeting specificity of GLUD2 is due to an amino acid substitution in the mitochondrial targeting sequence soon after the duplication event in the hominoid ancestor approximately 18-25 million years ago. PMID: 18688271
    13. study of molecular mechanisms regulating hGDH2 function by creating & analyzing mutants with single amino acid substitutions in the regulatory domain (antenna, pivot helix) of the protein PMID: 19393024
    14. GDH2 localizes mainly to mitochondria and to a lesser extent to the endoplasmic reticulum of cells PMID: 19428807

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  • 亞細胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    Glu/Leu/Phe/Val dehydrogenases family
  • 組織特異性：
    Expressed in retina, testis and, at a lower level, brain.
  • 數據庫鏈接：

    HGNC: 4336

    OMIM: 300144

    KEGG: hsa:2747

    STRING: 9606.ENSP00000327589

    UniGene: Hs.368538



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