在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GLUD2 Antibody

  • 中文名稱:
    GLUD2兔多克隆抗體
  • 貨號:
    CSB-PA009545ESR2HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: Glutamate dehydrogenase 2, mitochondrial antibody at 4μg/ml
      Lane 1: Mouse brain tissue
      Lane 2: 293T whole cell lysate
      Lane 3: Rat brain tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 61 kDa
      Observed band size: 61 kDa
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA009545ESR2HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) GLUD2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    DHE4_HUMAN antibody; GDH 2 antibody; GDH antibody; GDH2 antibody; GLUD2 antibody; GLUDP1 antibody; Glutamate dehydrogenase 2 antibody; Glutamate dehydrogenase 2 mitochondrial antibody; Glutamate dehydrogenase pseudogene 1 antibody; mitochondrial antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Mouse, Rat
  • 免疫原:
    Recombinant Human Glutamate dehydrogenase 2, mitochondrial protein (319-558AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission.
  • 基因功能參考文獻:
    1. hGDH2 evolution bestowed large human neurons with enhanced glutamate metabolizing capacity, thus strengthening cortical excitatory transmission. PMID: 26399640
    2. This study demonstrated that hGDH2 expression increases capacity for uptake and oxidative metabolism of glutamate, particularly during increased workload and hypoglycemia. PMID: 28032919
    3. This proliferation requires glutamate dehydrogenase 2, which synthesizes glutamate from ammonia and alpha-ketoglutarate and is expressed in MCF7 and T47D cells. Our findings provide insight into how cancer cells survive under glutamine deprivation conditions and thus contribute to elucidating the mechanisms of tumor growth. PMID: 29146184
    4. The expression of GLUD2 was identified in the cellular and subcellular compartments of numerous tissues. PMID: 27422263
    5. Notably, the introduction of GLUD2 did not affect glutamate levels in mice, consistent with observations in the primates. Instead, the metabolic effects of GLUD2 center on the tricarboxylic acid cycle, suggesting that GLUD2 affects carbon flux during early brain development, possibly supporting lipid biosynthesis. PMID: 27118840
    6. IDH1(R132H) exhibits a growth-inhibitory effect that is abrogated in the presence of glutamate dehydrogenase 2 (GLUD2), a hominoid-specific enzyme purportedly optimized to facilitate glutamate turnover in human forebrain. PMID: 25225364
    7. hGDH2 can operate efficiently in the relatively acidic environment that prevails in astrocytes following glutamate uptake [review] PMID: 24352816
    8. [review] Whereas GDH2 in most mammals is encoded by a single functional GLUD1 gene expressed widely, humans have acquired through retroposition an X-linked GLUD2 gene that encodes a highly homologous isoenzyme GDH2 expressed in testis and brain. PMID: 21420458
    9. GLUD2 glutamate dehydrogenase is expressed in neural and testicular supporting cells PMID: 20194501
    10. A gain-of-function rare polymorphism in hGDH2 hastens the onset of Parkinson's disease in hemizygous subjects. PMID: 19826450
    11. amino acid changes, acting in concert with Arg443Ser and Gly456Ala, ought to be responsible the unique properties of the brain-specific human isoenzyme PMID: 17924438
    12. Mitochondrial targeting specificity of GLUD2 is due to an amino acid substitution in the mitochondrial targeting sequence soon after the duplication event in the hominoid ancestor approximately 18-25 million years ago. PMID: 18688271
    13. study of molecular mechanisms regulating hGDH2 function by creating & analyzing mutants with single amino acid substitutions in the regulatory domain (antenna, pivot helix) of the protein PMID: 19393024
    14. GDH2 localizes mainly to mitochondria and to a lesser extent to the endoplasmic reticulum of cells PMID: 19428807

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion matrix.
  • 蛋白家族:
    Glu/Leu/Phe/Val dehydrogenases family
  • 組織特異性:
    Expressed in retina, testis and, at a lower level, brain.
  • 數據庫鏈接:

    HGNC: 4336

    OMIM: 300144

    KEGG: hsa:2747

    STRING: 9606.ENSP00000327589

    UniGene: Hs.368538



主站蜘蛛池模板: 日本55丰满熟妇厨房伦| 精品视频一区二区三三区四区| 精品无码一区二区三区爱欲九九 | 国产乱人伦中文无无码视频试看| 色婷婷综合中文久久一本| 日本十八禁视频无遮挡| 精品国产一区二区av麻豆不卡| 2018高清日本一道国产-在| 国产精品亚洲第一区在线观看| 99精品众筹模特自拍视频| 国产乱码精品一区二区三区中文| 亚洲人成人无码网www国产| 国产成人综合在线女婷五月99播放| 久久国产色欲av38| 国产高清色高清在线观看| 一本加勒比波多野结衣| 中国国语毛片免费观看视频| 国产av久久人人澡人人爱| 同性女女黄h片在线播放| 黑色丝袜无码中中文字幕| 大胆欧美熟妇xx| 秋霞国产午夜伦午夜福利片 | 97se亚洲综合自在线| 国内少妇高潮嗷嗷叫在线播放 | 99久热re在线精品99 6热视频| 国产乱妇乱子视频在播放| 高清粉嫩无套内谢国语播放| 中文字幕av一区乱码| 粗大猛烈进出高潮视频| 国产婷婷色综合av蜜臀av| 自慰小少妇毛又多又黑流白浆| 2018天天躁夜夜躁狠狠躁| 久久精品国产只有精品96| 亚洲色欲色欲www在线观看| 国产精品三级在线观看无码| 男人用嘴添女人私密视频| 又爽又黄又无遮挡网站| 又色又爽又黄高潮的免费视频| 天天做天天爱夜夜夜爽毛片| 免费视频爱爱太爽了激情| 国产成人久久av免费看|