在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GLUD2 Antibody

  • 中文名稱:
    GLUD2兔多克隆抗體
  • 貨號:
    CSB-PA009545ESR2HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: Glutamate dehydrogenase 2, mitochondrial antibody at 4μg/ml
      Lane 1: Mouse brain tissue
      Lane 2: 293T whole cell lysate
      Lane 3: Rat brain tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 61 kDa
      Observed band size: 61 kDa
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA009545ESR2HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) GLUD2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    DHE4_HUMAN antibody; GDH 2 antibody; GDH antibody; GDH2 antibody; GLUD2 antibody; GLUDP1 antibody; Glutamate dehydrogenase 2 antibody; Glutamate dehydrogenase 2 mitochondrial antibody; Glutamate dehydrogenase pseudogene 1 antibody; mitochondrial antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Mouse, Rat
  • 免疫原:
    Recombinant Human Glutamate dehydrogenase 2, mitochondrial protein (319-558AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission.
  • 基因功能參考文獻:
    1. hGDH2 evolution bestowed large human neurons with enhanced glutamate metabolizing capacity, thus strengthening cortical excitatory transmission. PMID: 26399640
    2. This study demonstrated that hGDH2 expression increases capacity for uptake and oxidative metabolism of glutamate, particularly during increased workload and hypoglycemia. PMID: 28032919
    3. This proliferation requires glutamate dehydrogenase 2, which synthesizes glutamate from ammonia and alpha-ketoglutarate and is expressed in MCF7 and T47D cells. Our findings provide insight into how cancer cells survive under glutamine deprivation conditions and thus contribute to elucidating the mechanisms of tumor growth. PMID: 29146184
    4. The expression of GLUD2 was identified in the cellular and subcellular compartments of numerous tissues. PMID: 27422263
    5. Notably, the introduction of GLUD2 did not affect glutamate levels in mice, consistent with observations in the primates. Instead, the metabolic effects of GLUD2 center on the tricarboxylic acid cycle, suggesting that GLUD2 affects carbon flux during early brain development, possibly supporting lipid biosynthesis. PMID: 27118840
    6. IDH1(R132H) exhibits a growth-inhibitory effect that is abrogated in the presence of glutamate dehydrogenase 2 (GLUD2), a hominoid-specific enzyme purportedly optimized to facilitate glutamate turnover in human forebrain. PMID: 25225364
    7. hGDH2 can operate efficiently in the relatively acidic environment that prevails in astrocytes following glutamate uptake [review] PMID: 24352816
    8. [review] Whereas GDH2 in most mammals is encoded by a single functional GLUD1 gene expressed widely, humans have acquired through retroposition an X-linked GLUD2 gene that encodes a highly homologous isoenzyme GDH2 expressed in testis and brain. PMID: 21420458
    9. GLUD2 glutamate dehydrogenase is expressed in neural and testicular supporting cells PMID: 20194501
    10. A gain-of-function rare polymorphism in hGDH2 hastens the onset of Parkinson's disease in hemizygous subjects. PMID: 19826450
    11. amino acid changes, acting in concert with Arg443Ser and Gly456Ala, ought to be responsible the unique properties of the brain-specific human isoenzyme PMID: 17924438
    12. Mitochondrial targeting specificity of GLUD2 is due to an amino acid substitution in the mitochondrial targeting sequence soon after the duplication event in the hominoid ancestor approximately 18-25 million years ago. PMID: 18688271
    13. study of molecular mechanisms regulating hGDH2 function by creating & analyzing mutants with single amino acid substitutions in the regulatory domain (antenna, pivot helix) of the protein PMID: 19393024
    14. GDH2 localizes mainly to mitochondria and to a lesser extent to the endoplasmic reticulum of cells PMID: 19428807

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion matrix.
  • 蛋白家族:
    Glu/Leu/Phe/Val dehydrogenases family
  • 組織特異性:
    Expressed in retina, testis and, at a lower level, brain.
  • 數據庫鏈接:

    HGNC: 4336

    OMIM: 300144

    KEGG: hsa:2747

    STRING: 9606.ENSP00000327589

    UniGene: Hs.368538



主站蜘蛛池模板: 成人无码av一区二区三区| 久久久www成人免费毛片| 无码专区—va亚洲v专区vr| 国产乱人伦偷精品视频免| 一二三四在线观看视频韩国| 欧美乱大交xxxxx潮喷l头像| 国产二级一片内射视频播放| 西西人体大胆扒开下部337卩| 亚洲人成网站18禁止大app| 猫咪www免费人成人入口| 亚洲综合激情另类小说区| 欧美日韩一本无线码专区| 少妇大叫好爽受不了午夜视频| 特黄大片又粗又大又暴 | 四虎免费最新在线永久4hu| 欧美丰满熟妇xxxx性| 色翁荡息又大又硬又粗又爽电影| 亚洲色成人网站永久| 免费看国产zzzwww色| 国产一区二区三区小说| 亚洲一区激情校园小说| 青青草国产三级精品三级 | 亚洲欧美中文日韩v在线观看| 高清粉嫩无套内谢国语播放| 内射一区二区精品视频在线观看 | 国产精品自在拍首页视频8| 久久精品国产欧美日韩| 国内精品久久久久影院薰衣草 | 欧美伊人色综合久久天天| 国产卡一卡二卡三无线乱码新区| 色猫咪av在线观看| 国产av国片精品一区二区| 一二三四区无产乱码1000集| 欧美成人一区二区三区在线视频| 久久精品成人欧美大片| 亚洲人成人77777网站| 中文字幕日韩精品一区二区三区| 香蕉蕉亚亚洲aav综合| 噜噜高清欧美内射短视频| 髙清国产性猛交xxxand| 精品婷婷色一区二区三区|