在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GLUD2 Antibody

  • 中文名稱:
    GLUD2兔多克隆抗體
  • 貨號:
    CSB-PA009545GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    DHE4_HUMAN antibody; GDH 2 antibody; GDH antibody; GDH2 antibody; GLUD2 antibody; GLUDP1 antibody; Glutamate dehydrogenase 2 antibody; Glutamate dehydrogenase 2 mitochondrial antibody; Glutamate dehydrogenase pseudogene 1 antibody; mitochondrial antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human GLUD2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission.
  • 基因功能參考文獻:
    1. hGDH2 evolution bestowed large human neurons with enhanced glutamate metabolizing capacity, thus strengthening cortical excitatory transmission. PMID: 26399640
    2. This study demonstrated that hGDH2 expression increases capacity for uptake and oxidative metabolism of glutamate, particularly during increased workload and hypoglycemia. PMID: 28032919
    3. This proliferation requires glutamate dehydrogenase 2, which synthesizes glutamate from ammonia and alpha-ketoglutarate and is expressed in MCF7 and T47D cells. Our findings provide insight into how cancer cells survive under glutamine deprivation conditions and thus contribute to elucidating the mechanisms of tumor growth. PMID: 29146184
    4. The expression of GLUD2 was identified in the cellular and subcellular compartments of numerous tissues. PMID: 27422263
    5. Notably, the introduction of GLUD2 did not affect glutamate levels in mice, consistent with observations in the primates. Instead, the metabolic effects of GLUD2 center on the tricarboxylic acid cycle, suggesting that GLUD2 affects carbon flux during early brain development, possibly supporting lipid biosynthesis. PMID: 27118840
    6. IDH1(R132H) exhibits a growth-inhibitory effect that is abrogated in the presence of glutamate dehydrogenase 2 (GLUD2), a hominoid-specific enzyme purportedly optimized to facilitate glutamate turnover in human forebrain. PMID: 25225364
    7. hGDH2 can operate efficiently in the relatively acidic environment that prevails in astrocytes following glutamate uptake [review] PMID: 24352816
    8. [review] Whereas GDH2 in most mammals is encoded by a single functional GLUD1 gene expressed widely, humans have acquired through retroposition an X-linked GLUD2 gene that encodes a highly homologous isoenzyme GDH2 expressed in testis and brain. PMID: 21420458
    9. GLUD2 glutamate dehydrogenase is expressed in neural and testicular supporting cells PMID: 20194501
    10. A gain-of-function rare polymorphism in hGDH2 hastens the onset of Parkinson's disease in hemizygous subjects. PMID: 19826450
    11. amino acid changes, acting in concert with Arg443Ser and Gly456Ala, ought to be responsible the unique properties of the brain-specific human isoenzyme PMID: 17924438
    12. Mitochondrial targeting specificity of GLUD2 is due to an amino acid substitution in the mitochondrial targeting sequence soon after the duplication event in the hominoid ancestor approximately 18-25 million years ago. PMID: 18688271
    13. study of molecular mechanisms regulating hGDH2 function by creating & analyzing mutants with single amino acid substitutions in the regulatory domain (antenna, pivot helix) of the protein PMID: 19393024
    14. GDH2 localizes mainly to mitochondria and to a lesser extent to the endoplasmic reticulum of cells PMID: 19428807

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion matrix.
  • 蛋白家族:
    Glu/Leu/Phe/Val dehydrogenases family
  • 組織特異性:
    Expressed in retina, testis and, at a lower level, brain.
  • 數據庫鏈接:

    HGNC: 4336

    OMIM: 300144

    KEGG: hsa:2747

    STRING: 9606.ENSP00000327589

    UniGene: Hs.368538



主站蜘蛛池模板: 狠狠色噜噜狠狠狠狠色综合久| 成人区精品一区二区不卡| 成人性做爰aaa片免费看| 99在线精品一区二区三区| 亚洲欧美日韩在线资源观看| 久久精品国产国产精品四凭 | 老子影院无码午夜伦不卡| 国产偷窥熟女高潮精品视频| 性色av蜜臀av色欲av| 麻豆精品国产精华精华液好用吗| 国产艳妇av在线出轨| 国产精品久久自在自线不卡 | 中文字幕aⅴ人妻一区二区| 国产美女被遭高潮免费视频 | 国产三级精品三级在线专1| 果冻传媒亚洲区二期| 国产露脸无套对白在线播放| 日韩精品乱码av一区二区| 欧美肥婆性猛交xxxx| 色噜噜亚洲男人的天堂www| 欧美日韩亚洲国产欧美电影 | 亚洲最大无码av网站观看| 午夜dj在线观看高清在线视频完整版 | 国产成人a人亚洲精品无码 | 日本少妇三级hd激情在线观看 | 蜜臀av综合网| 国产成熟妇女性视频电影| 国产精品白丝av网站在线观看| 国产精品国产亚洲精品看不卡| 成年女人18级毛片毛片免费| 国产成人亚洲精品另类动态| 乱码精品一区二区三区| 一个人在线观看免费视频www| 老熟妇仑乱视频一区二区| 欧美va亚洲va在线观看日本| 福利视频一二三在线观看| 国产成人综合久久免费导航| 久久av高清无码| 娇妻被黑人粗大高潮白浆| 欧洲女人性开放免费网站| 中文字幕亚洲综合久久蜜桃 |