在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GLUD2 Antibody

  • 中文名稱:
    GLUD2兔多克隆抗體
  • 貨號:
    CSB-PA009545GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    DHE4_HUMAN antibody; GDH 2 antibody; GDH antibody; GDH2 antibody; GLUD2 antibody; GLUDP1 antibody; Glutamate dehydrogenase 2 antibody; Glutamate dehydrogenase 2 mitochondrial antibody; Glutamate dehydrogenase pseudogene 1 antibody; mitochondrial antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human GLUD2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission.
  • 基因功能參考文獻:
    1. hGDH2 evolution bestowed large human neurons with enhanced glutamate metabolizing capacity, thus strengthening cortical excitatory transmission. PMID: 26399640
    2. This study demonstrated that hGDH2 expression increases capacity for uptake and oxidative metabolism of glutamate, particularly during increased workload and hypoglycemia. PMID: 28032919
    3. This proliferation requires glutamate dehydrogenase 2, which synthesizes glutamate from ammonia and alpha-ketoglutarate and is expressed in MCF7 and T47D cells. Our findings provide insight into how cancer cells survive under glutamine deprivation conditions and thus contribute to elucidating the mechanisms of tumor growth. PMID: 29146184
    4. The expression of GLUD2 was identified in the cellular and subcellular compartments of numerous tissues. PMID: 27422263
    5. Notably, the introduction of GLUD2 did not affect glutamate levels in mice, consistent with observations in the primates. Instead, the metabolic effects of GLUD2 center on the tricarboxylic acid cycle, suggesting that GLUD2 affects carbon flux during early brain development, possibly supporting lipid biosynthesis. PMID: 27118840
    6. IDH1(R132H) exhibits a growth-inhibitory effect that is abrogated in the presence of glutamate dehydrogenase 2 (GLUD2), a hominoid-specific enzyme purportedly optimized to facilitate glutamate turnover in human forebrain. PMID: 25225364
    7. hGDH2 can operate efficiently in the relatively acidic environment that prevails in astrocytes following glutamate uptake [review] PMID: 24352816
    8. [review] Whereas GDH2 in most mammals is encoded by a single functional GLUD1 gene expressed widely, humans have acquired through retroposition an X-linked GLUD2 gene that encodes a highly homologous isoenzyme GDH2 expressed in testis and brain. PMID: 21420458
    9. GLUD2 glutamate dehydrogenase is expressed in neural and testicular supporting cells PMID: 20194501
    10. A gain-of-function rare polymorphism in hGDH2 hastens the onset of Parkinson's disease in hemizygous subjects. PMID: 19826450
    11. amino acid changes, acting in concert with Arg443Ser and Gly456Ala, ought to be responsible the unique properties of the brain-specific human isoenzyme PMID: 17924438
    12. Mitochondrial targeting specificity of GLUD2 is due to an amino acid substitution in the mitochondrial targeting sequence soon after the duplication event in the hominoid ancestor approximately 18-25 million years ago. PMID: 18688271
    13. study of molecular mechanisms regulating hGDH2 function by creating & analyzing mutants with single amino acid substitutions in the regulatory domain (antenna, pivot helix) of the protein PMID: 19393024
    14. GDH2 localizes mainly to mitochondria and to a lesser extent to the endoplasmic reticulum of cells PMID: 19428807

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion matrix.
  • 蛋白家族:
    Glu/Leu/Phe/Val dehydrogenases family
  • 組織特異性:
    Expressed in retina, testis and, at a lower level, brain.
  • 數據庫鏈接:

    HGNC: 4336

    OMIM: 300144

    KEGG: hsa:2747

    STRING: 9606.ENSP00000327589

    UniGene: Hs.368538



主站蜘蛛池模板: 国产欧美日韩综合视频专区| 97久久婷婷五月综合色d啪蜜芽| 在线看片免费人成视频影院看| 亚洲a∨精品一区二区三区| 亚洲人成电影在线天堂色| 好男人社区www在线观看| 乱人伦人妻中文字幕无码久久网| 日本大片免a费观看视频三区| 玩弄漂亮少妇高潮白浆 | 韩产日产国产欧产| 亚洲性色av一区二区三区| 亚洲中文字幕伊人久久无码| 麻豆成人av不卡一二三区| 亚洲综合色区中文字幕| 十八禁裸体www网站免费观看| 久久国产劲暴∨内射新川| 新普新京亚洲欧美日韩国产| 最近最好的中文字幕2019免费| 国产一在线精品一区在线观看| 人妻少妇精品中文字幕av| 成年男人裸j照无遮挡无码| 亚洲精品无码久久久久av老牛| 久久国产亚洲高清观看| 天天摸日日摸狠狠添| 国产午夜福利100集发布| 成人免费午夜无码视频在线播放| 国产成年女人毛片80s网站| 国产精品久久久福利| 无码h片在线观看网站| 永久免费男同av无码入口| 欲妇荡岳丰满少妇岳| 亚洲综合天堂av网站在线观看| 丁香五月亚洲综合在线| 亚洲成a人片77777国产| 亚洲精品久久国产精品| 欧美婷婷六月丁香综合色| 日本丰满白嫩大屁股ass| 亚洲人成网站在线无码| 欧美国产日本高清不卡| 国产成人精品a视频| 大肉大捧一进一出视频出来呀 |