在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Ferroptosis suppressor protein 1 (AIFM2), partial

  • 中文名稱:
    Recombinant Human Ferroptosis suppressor protein 1 (AIFM2), partial
  • 貨號(hào):
    CSB-EP874794HU
  • 規(guī)格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
    AIFM2
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    45.0 kDa
  • 表達(dá)區(qū)域:
    28-373aa
  • 氨基酸序列
    SQLQALNVPFMLVDMKDSFHHNVAALRASVETGFAKKTFISYSVTFKDNFRQGLVVGIDLKNQMVLLQGGEALPFSHLILATGSTGPFPGKFNEVSSQQAAIQAYEDMVRQVQRSRFIVVVGGGSAGVEMAAEIKTEYPEKEVTLIHSQVALADKELLPSVRQEVKEILLRKGVQLLLSERVSNLEELPLNEYREYIKVQTDKGTEVATNLVILCTGIKINSSAYRKAFESRLASSGALRVNEHLQVEGHSNVYAIGDCADVRTPKMAYLAGLHANIAVANIVNSVKQRPLQAYKPGALTFLLSMGRNDGVGQISGFYVGRLMVRLTKSRDLFVSTSWKTMRQSPP
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    C-terminal 6xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    A NAD(P)H-dependent oxidoreductase involved in cellular oxidative stress response. At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical-trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis. Cooperates with GPX4 to suppress phospholipid peroxidation and ferroptosis. This anti-ferroptotic function is independent of cellular glutathione levels. May play a role in mitochondrial stress signaling. Upon oxidative stress, associates with the lipid peroxidation end product 4-hydroxy-2-nonenal (HNE) forming a lipid adduct devoid of oxidoreductase activity, which then translocates from mitochondria into the nucleus triggering DNA damage and cell death. Capable of DNA binding in a non-sequence specific way.
  • 基因功能參考文獻(xiàn):
    1. Low AIFM2 expression is associated with T-cell lymphoblastic lymphoma. PMID: 28534937
    2. AIF and its family member protein, AMID, are rotenone-sensitive NADH:ubiquinone oxidoreductases (of the NDH-2 type). PMID: 26063804
    3. HUHS1015 increased nuclear localization of apoptosis-inducing factor-homologous mitochondrion-associated inducer of death (AMID). PMID: 25244912
    4. induces caspase-independent apoptosis PMID: 11980907
    5. encodes a homologue of the apoptosis-inducing factor PMID: 12135761
    6. AMID is a p53-downstream gene involved in tumorigenesis. PMID: 15273740
    7. Reasults establish a link between coenzyme and DNA binding that likely impacts on the physiological role of AMID in cellular apoptosis. PMID: 15958387
    8. study of cellular localization of the endonuclease G, AIF & AMID during apoptosis using bioinformatics and image analysis PMID: 17347867
    9. AIF-M2 lessens survival cell signaling in the presence of foreign (e.g. bacterial and (retro)viral) cytosolic DNA, thus contributing to the onset of apoptosis PMID: 17711848

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Lipid droplet. Cell membrane; Lipid-anchor. Cytoplasm. Mitochondrion membrane. Nucleus.
  • 蛋白家族:
    FAD-dependent oxidoreductase family
  • 組織特異性:
    Detected in most normal tissues as two transcripts of 1.8 and 4.0 kb in length, respectively. Highly expressed in heart, moderately in liver and skeletal muscles, and expressed at low levels in placenta, lung, kidney, and pancreas. Both transcripts expres
  • 數(shù)據(jù)庫鏈接:

    HGNC: 21411

    OMIM: 605159

    KEGG: hsa:84883

    STRING: 9606.ENSP00000312370

    UniGene: Hs.650680



主站蜘蛛池模板: 97久久婷婷五月综合色d啪蜜芽| 亚洲国精产品一二二线| 风韵犹存丰满大屁股熟妇| 国产片a国产片免费看视频| 97se色综合一区二区二区| 人人妻人人澡人人爽| 中文人妻av久久人妻18| 一色屋精品视频在线观看免费 | 天堂网在线.www天堂在线资源| 变态 另类 欧美 大码 日韩| 中文亚洲无线码49vv| 无码专区—va亚洲v专区| 97精品国产一区二区三区| 后入内射欧美99二区视频| 国产麻豆一精品av一免费软件| 2021久久国自产拍精品| 丰满人妻熟妇乱偷人无码| 婷婷久久综合九色综合绿巨人| 香蕉久久国产超碰青草| 色一情一乱一乱一区99av白浆| 中国女人内谢69xxxxxa片| 亚洲欧美成人a∨观看| 亚洲精品国产一区二区图片| 日本特黄特色aaa大片免费| 香蕉成人伊视频在线观看| 丰满少妇大叫太大太粗| 999精品无码a片在线1级| 污污内射久久一区二区欧美日韩| 色8久久人人97超碰香蕉987| av片日韩一区二区三区在线观看| 天堂网在线观看| 久久国产成人精品国产成人亚洲| 欧美猛少妇色xxxxx猛交| 亚洲精品成人网站在线播放| 人人爽人人澡人人人人妻| 久久综合伊人| 久久综合99re88久久爱| 在线人成免费视频69国产| 内射人妻少妇无码一本一道| 精品人妻无码专区中文字幕| 尤物国精品午夜福利视频|