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  4. AIFM2 Antibody

AIFM2 Antibody

  • 中文名稱：
    AIFM2兔多克隆抗體
  • 貨號：
    CSB-PA000868
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of COS7 cells using AMID Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    AIFM2
  • 別名：
    5430437E11Rik antibody; aifm2 antibody; AIFM2_HUMAN antibody; AMID antibody; Apoptosis inducing factor (AIF) homologous mitochondrion associated inducer of death antibody; Apoptosis inducing factor (AIF) like mitochondrion associated inducer of death antibody; Apoptosis inducing factor mitochondrion associated 2 antibody; Apoptosis-inducing factor 2 antibody; Apoptosis-inducing factor homologous mitochondrion-associated inducer of death antibody; Apoptosis-inducing factor-like mitochondrion-associated inducer of death antibody; Cys51Stop antibody; HGNC11998 antibody; p53 responsive gene 3 antibody; p53 tumor suppressor antibody; p53-responsive gene 3 protein antibody; PRG3 antibody; TRP53 antibody; Tumor protein p53 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Monkey
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human AMID.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    A NAD(P)H-dependent oxidoreductase involved in cellular oxidative stress response. At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical-trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis. Cooperates with GPX4 to suppress phospholipid peroxidation and ferroptosis. This anti-ferroptotic function is independent of cellular glutathione levels. May play a role in mitochondrial stress signaling. Upon oxidative stress, associates with the lipid peroxidation end product 4-hydroxy-2-nonenal (HNE) forming a lipid adduct devoid of oxidoreductase activity, which then translocates from mitochondria into the nucleus triggering DNA damage and cell death. Capable of DNA binding in a non-sequence specific way.
  • 基因功能參考文獻：
    1. Low AIFM2 expression is associated with T-cell lymphoblastic lymphoma. PMID: 28534937
    2. AIF and its family member protein, AMID, are rotenone-sensitive NADH:ubiquinone oxidoreductases (of the NDH-2 type). PMID: 26063804
    3. HUHS1015 increased nuclear localization of apoptosis-inducing factor-homologous mitochondrion-associated inducer of death (AMID). PMID: 25244912
    4. induces caspase-independent apoptosis PMID: 11980907
    5. encodes a homologue of the apoptosis-inducing factor PMID: 12135761
    6. AMID is a p53-downstream gene involved in tumorigenesis. PMID: 15273740
    7. Reasults establish a link between coenzyme and DNA binding that likely impacts on the physiological role of AMID in cellular apoptosis. PMID: 15958387
    8. study of cellular localization of the endonuclease G, AIF & AMID during apoptosis using bioinformatics and image analysis PMID: 17347867
    9. AIF-M2 lessens survival cell signaling in the presence of foreign (e.g. bacterial and (retro)viral) cytosolic DNA, thus contributing to the onset of apoptosis PMID: 17711848

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  • 亞細胞定位：
    Lipid droplet. Cell membrane; Lipid-anchor. Cytoplasm. Mitochondrion membrane. Nucleus.
  • 蛋白家族：
    FAD-dependent oxidoreductase family
  • 組織特異性：
    Detected in most normal tissues as two transcripts of 1.8 and 4.0 kb in length, respectively. Highly expressed in heart, moderately in liver and skeletal muscles, and expressed at low levels in placenta, lung, kidney, and pancreas. Both transcripts expres
  • 數據庫鏈接：

    HGNC: 21411

    OMIM: 605159

    KEGG: hsa:84883

    STRING: 9606.ENSP00000312370

    UniGene: Hs.650680



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