在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human F-box/LRR-repeat protein 2 (FBXL2)

  • 中文名稱:
    人FBXL2重組蛋白
  • 貨號:
    CSB-BP892134HU
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人FBXL2重組蛋白
  • 貨號:
    CSB-EP892134HU-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人FBXL2重組蛋白
  • 貨號:
    CSB-MP892134HU
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    Name:FBXL2 Synonyms:FBL2, FBL3
  • Uniprot No.:
  • 別名:
    DKFZP564P0622; F box and leucine rich repeat protein 2; F box protein containing leucine rich repeats; F box protein FBL2/FBL3; F box/LRR repeat protein 2; F-box and leucine-rich repeat protein 2; F-box protein FBL2/FBL3; F-box/LRR-repeat protein 2; FBL 2; FBL 3; FBL2; FBL3; FBXL 2; FBXL2; FBXL2_HUMAN
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區(qū)域:
    1-423
  • 氨基酸序列
    MVFSNNDEGL INKKLPKELL LRIFSFLDIV TLCRCAQISK AWNILALDGS NWQRIDLFNF QTDVEGRVVE NISKRCGGFL RKLSLRGCIG VGDSSLKTFA QNCRNIEHLN LNGCTKITDS TCYSLSRFCS KLKHLDLTSC VSITNSSLKG ISEGCRNLEY LNLSWCDQIT KDGIEALVRG CRGLKALLLR GCTQLEDEAL KHIQNYCHEL VSLNLQSCSR ITDEGVVQIC RGCHRLQALC LSGCSNLTDA SLTALGLNCP RLQILEAARC SHLTDAGFTL LARNCHELEK MDLEECILIT DSTLIQLSIH CPKLQALSLS HCELITDDGI LHLSNSTCGH ERLRVLELDN CLLITDVALE HLENCRGLER LELYDCQQVT RAGIKRMRAQ LPHVKVHAYF APVTPPTAVA GSGQRLCRCC VIL
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy. PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant.
  • 基因功能參考文獻:
    1. PTEN counteracts FBXL2 to promote IP3R3- and Ca(2+)-mediated apoptosis limiting tumour growth PMID: 28614300
    2. these results uncover a previous unknown network involving FBXL2 and FoxM1 in the regulation of gastric cancer growth. PMID: 26790640
    3. FBXL2 recognizes Trp-73 within NALP3 for interaction and targets Lys-689 within NALP3 for ubiquitin ligation and degradation. PMID: 26037928
    4. FBXL2 mediates the ubiquitylation and degradation of p85beta on cell membranes. PMID: 23604317
    5. These results suggested that the involvement of the reduction of FBL2 level is related to AD progression. PMID: 22455980
    6. FBXL2 is indispensible regulator of mitosis that serves as a tumor suppressor PMID: 22020328
    7. FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation. PMID: 22323446
    8. FBL2 is a novel and dual regulator of amyloid precursor protein (APP) metabolism through FBL2-dependent ubiquitination of APP. PMID: 22399757

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Lipid-anchor.
  • 組織特異性:
    Expressed in brain, heart, kidney, liver, lung, pancreas and placenta.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 13598

    OMIM: 605652

    KEGG: hsa:25827

    STRING: 9606.ENSP00000417601

    UniGene: Hs.475872



主站蜘蛛池模板: av无码电影一区二区三区| 天天射寡妇射| 天堂а√在线官网| 成人一在线视频日韩国产| 亚洲精品揄拍自拍首页一| 欧美丰满熟妇xx猛交| 少妇高清精品毛片在线视频| 国产精品成人一区二区不卡| 四虎成人精品永久网站| 欧美又大又色又爽aaaa片| 熟妇人妻无码xxx视频| 爆乳护士一区二区三区在线播放| 天干夜天天夜天干天2004年| 午夜福利视频| 亚洲高清乱码午夜电影网| 国产成人无码av大片大片在线观看| 日韩欧美亚洲国产精品字幕久久久| 人人妻人人狠人人爽 | 亚洲精品成人网站在线| 欧美牲交a欧美牲交aⅴ免费真| 国产a国产片国产| 国产欧美日韩视频一区二区三区| 亚洲中文字幕国产综合| 特黄特色大片免费播放器图片| 欧美一区二区三区激情| 最新国产aⅴ精品无码| 狠狠色丁香久久综合| 国产精品十八禁在线观看| 亚洲国产精品不卡av在线 | 中文字字幕在线成人av电影| 色噜噜狠狠色综合久夜色撩人| 污18禁污色黄网站免费| 99大香伊乱码一区二区| 国产又大又黑又粗免费视频| 亚洲日韩欧美一区二区三区在线| 人人玩人人添人人澡欧美| 一边吃奶一边做动态图| 欧美亚洲一区二区三区| 少妇精品偷拍高潮少妇小说| 亚洲精品黑牛一区二区三区| 丰满少妇女裸体bbw|