在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. FBXL2 Antibody

FBXL2 Antibody

  • 中文名稱：
    FBXL2兔多克隆抗體
  • 貨號：
    CSB-PA892134LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunofluorescence staining of Hela cells with CSB-PA892134LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) FBXL2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    FBXL2
  • 別名：
    DKFZP564P0622 antibody; F box and leucine rich repeat protein 2 antibody; F box protein containing leucine rich repeats antibody; F box protein FBL2/FBL3 antibody; F box/LRR repeat protein 2 antibody; F-box and leucine-rich repeat protein 2 antibody; F-box protein FBL2/FBL3 antibody; F-box/LRR-repeat protein 2 antibody; FBL 2 antibody; FBL 3 antibody; FBL2 antibody; FBL3 antibody; FBXL 2 antibody; FBXL2 antibody; FBXL2_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human F-box/LRR-repeat protein 2 protein (1-423AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，FBXL2 Antibody (CSB-PA892134LA01HU)，的標記方式是Non-conjugated。對于FBXL2 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA892134LB01HU FBXL2 Antibody, HRP conjugated ELISA
    FITC CSB-PA892134LC01HU FBXL2 Antibody, FITC conjugated
    Biotin CSB-PA892134LD01HU FBXL2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy. PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant.
  • 基因功能參考文獻：
    1. PTEN counteracts FBXL2 to promote IP3R3- and Ca(2+)-mediated apoptosis limiting tumour growth PMID: 28614300
    2. these results uncover a previous unknown network involving FBXL2 and FoxM1 in the regulation of gastric cancer growth. PMID: 26790640
    3. FBXL2 recognizes Trp-73 within NALP3 for interaction and targets Lys-689 within NALP3 for ubiquitin ligation and degradation. PMID: 26037928
    4. FBXL2 mediates the ubiquitylation and degradation of p85beta on cell membranes. PMID: 23604317
    5. These results suggested that the involvement of the reduction of FBL2 level is related to AD progression. PMID: 22455980
    6. FBXL2 is indispensible regulator of mitosis that serves as a tumor suppressor PMID: 22020328
    7. FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation. PMID: 22323446
    8. FBL2 is a novel and dual regulator of amyloid precursor protein (APP) metabolism through FBL2-dependent ubiquitination of APP. PMID: 22399757

    顯示更多

    收起更多

  • 亞細胞定位：
    Membrane; Lipid-anchor.
  • 組織特異性：
    Expressed in brain, heart, kidney, liver, lung, pancreas and placenta.
  • 數據庫鏈接：

    HGNC: 13598

    OMIM: 605652

    KEGG: hsa:25827

    STRING: 9606.ENSP00000417601

    UniGene: Hs.475872



主站蜘蛛池模板： 国内精品久久久久影院蜜芽 | 无码抽搐高潮喷水流白浆| 一区二区三区无码高清视频| √最新版天堂资源网在线| 亚洲午夜成人久久久久久| 成人影院永久免费观看网址| 亚洲免费观看视频| 欧美 日韩 人妻 高清 中文| 成人做爰100部片免费下载| 久久精品人人做人人综合试看| 狠狠色色综合网站| 亚洲第一区无码专区| 天天看片视频免费观看| 日本熟妇美熟bbw| 精品卡一卡二卡3卡高清乱码| 精品人妻码一区二区三区| 麻豆精产一二三产区| 人人妻人人妻人人人人妻人人| 一本一道av无码中文字幕﹣百度| 久久综合九色欧美综合狠狠| 久久中文精品无码中文字幕| 久久一卡二卡三卡四卡| 国产熟妇另类久久久久| 亚欧无线一线二线三线区别| 影音先锋无码a∨男人资源站| 亚洲日本一区二区三区在线| 99re热这里只有精品视频| 曰本极品少妇videossexhd| 亚洲中文字幕日产无码2020| 亚洲性久久久影院| 人与动人物xxxx毛片人与狍 | 亚洲人成电影网站色| av无码人妻波多野结衣| 国产后入又长又硬| 大战熟女丰满人妻av| 久久69精品久久久久久hb| 久久国产免费直播| 曰本女人与公拘交酡| 国产婷婷精品av在线| 99亚洲乱人伦aⅴ精品| 亚洲欧美丝袜精品久久|