在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. FBXL2 Antibody, HRP conjugated

FBXL2 Antibody, HRP conjugated

  • 中文名稱：
    FBXL2兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA892134LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) FBXL2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    FBXL2
  • 別名：
    DKFZP564P0622 antibody; F box and leucine rich repeat protein 2 antibody; F box protein containing leucine rich repeats antibody; F box protein FBL2/FBL3 antibody; F box/LRR repeat protein 2 antibody; F-box and leucine-rich repeat protein 2 antibody; F-box protein FBL2/FBL3 antibody; F-box/LRR-repeat protein 2 antibody; FBL 2 antibody; FBL 3 antibody; FBL2 antibody; FBL3 antibody; FBXL 2 antibody; FBXL2 antibody; FBXL2_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human F-box/LRR-repeat protein 2 protein (1-423AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy. PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant.
  • 基因功能參考文獻：
    1. PTEN counteracts FBXL2 to promote IP3R3- and Ca(2+)-mediated apoptosis limiting tumour growth PMID: 28614300
    2. these results uncover a previous unknown network involving FBXL2 and FoxM1 in the regulation of gastric cancer growth. PMID: 26790640
    3. FBXL2 recognizes Trp-73 within NALP3 for interaction and targets Lys-689 within NALP3 for ubiquitin ligation and degradation. PMID: 26037928
    4. FBXL2 mediates the ubiquitylation and degradation of p85beta on cell membranes. PMID: 23604317
    5. These results suggested that the involvement of the reduction of FBL2 level is related to AD progression. PMID: 22455980
    6. FBXL2 is indispensible regulator of mitosis that serves as a tumor suppressor PMID: 22020328
    7. FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation. PMID: 22323446
    8. FBL2 is a novel and dual regulator of amyloid precursor protein (APP) metabolism through FBL2-dependent ubiquitination of APP. PMID: 22399757

    顯示更多

    收起更多

  • 亞細胞定位：
    Membrane; Lipid-anchor.
  • 組織特異性：
    Expressed in brain, heart, kidney, liver, lung, pancreas and placenta.
  • 數據庫鏈接：

    HGNC: 13598

    OMIM: 605652

    KEGG: hsa:25827

    STRING: 9606.ENSP00000417601

    UniGene: Hs.475872



主站蜘蛛池模板： 国产欧美另类久久久精品丝瓜| 国产精品免费无遮挡无码永久视频| 欧美日韩精品一区二区视频| 性欧美性另类巨大| 玩弄了裸睡少妇人妻野战| 欧美成人精品午夜免费影视| 欧美三级在线播放线观看| 国产伦精品一区二区三区妓女| 欧美乱大交xxxxx潮喷l头像 | 国产一区二区三区精品av| 无尺码精品产品国产| 国产又爽又大又黄a片| 亚洲国产成人乱码| 香港日本三级亚洲三级 | 在线播放偷拍一区精品| 精品国产av一二三四区| 欧美高清freexxxx性| 综合激情亚洲丁香社区| 午夜亚洲国产理论片二级港台二级| 欧美老人巨大xxxx做受| 国产免费久久久久久无码| 久久香蕉国产线看观看手机| 亚洲乱码中文字幕综合234| 一区二区三区在线 | 欧洲| 波多野结衣av一区二区全免费观看| 国产精品69人妻无码久久| 四虎成人精品永久在线视频| 国产精品h片在线播放| 欧美成人免费全部| 日韩精品亚洲人旧成在线| 精品乱码一区二区三四五区| 婷婷五月综合激情| 国产av激情无码久久| 末发育女av片一区二区| 天天爽夜夜爽人人爽免费| 国产精品无码人妻一区二区在线 | 综合欧美亚洲日本一区| 早起邻居人妻奶罩太松av| 欧洲亚洲精品久久久久| 忘忧草日本在线www| 精品日产高清卡4卡5区别|