在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Dual specificity protein kinase CLK2 (CLK2), partial

  • 中文名稱:
    Recombinant Human Dual specificity protein kinase CLK2(CLK2),partial
  • 貨號:
    CSB-EP005558HU1a6
  • 規格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    CLK2
  • Uniprot No.:
  • 別名:
    CDC like kinase 2; CDC-like kinase 2; CLK 2; CLK kinase; CLK2; Clk2 Scamp3; CLK2_HUMAN; Dual specificity protein kinase CLK2; hCLK 2; hCLK2; Tu52
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    56.7 kDa
  • 表達區域:
    138-499aa
  • 氨基酸序列
    RRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-B2M-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Tris-based buffer,50% glycerol
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Phosphorylates PAGE4 at several serine and threonine residues and this phosphorylation attenuates the ability of PAGE4 to potentiate the transcriptional activator activity of JUN.
  • 基因功能參考文獻:
    1. These findings suggest that CLK2 plays a critical role in controlling the cell cycle and survival of glioblastoma PMID: 27050366
    2. Loss of CLK2 in luminal breast cancer cells leads to the upregulation of epithelial-to-mesenchymal transition (EMT)-related genes and a switch to mesenchymal splice variants of several genes. PMID: 25670169
    3. LAMMER/Cdc2-like kinase, represented by Doa and its mammalian homolog CLK2, is a critical and conserved component in the regulatory program of the mitosis-to-meiosis switch PMID: 23376537
    4. AKT activation controls cell survival to ionizing radiation by phosphorylating CLK2, revealing an important regulatory mechanism required for promoting cell survival. PMID: 20682768
  • 亞細胞定位:
    Nucleus.; [Isoform 1]: Nucleus. Nucleus speckle.; [Isoform 2]: Nucleus speckle.
  • 蛋白家族:
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, Lammer subfamily
  • 組織特異性:
    Endothelial cells. Expressed in androgen-dependent prostate cancer cells.
  • 數據庫鏈接:

    HGNC: 2069

    OMIM: 602989

    KEGG: hsa:1196

    STRING: 9606.ENSP00000354856

    UniGene: Hs.73986



主站蜘蛛池模板: 97伦伦午夜电影理伦片| 人人妻人人澡人人爽欧美一区| 国产免费一区二区视频| 国产丝袜无码一区二区视频| 思思99re6国产在线播放| av天堂久久精品影音先锋| 久久综合色老色| 曰批免费视频播放免费| 亚洲第一区无码专区| 成全世界免费高清观看| 亚洲香蕉网久久综合影视| 无码综合天天久久综合网色吧影院| 在线播放午夜理论片| 色www视频永久免费| 国产精品爆乳在线播放第一人称 | 久久精品日日躁夜夜躁| 97丨九色丨国产人妻熟女| 99热这里只有精品免费播放| 精品久久久久久无码人妻| 蜜桃av无码免费看永久| 免费啪视频在线观看视频日本 | 色综合久久久久久久久五月| 曰韩人妻无码一区二区三区综合部| 99精品无码一区二区| 亚洲国产99精品国自产拍| 欧美 日韩 国产 另类 图片区| 大白肥妇bbvbbw高潮| 人人妻人人澡人人爽人人dvd| 7878成人国产在线观看| 97色成人综合网站| 动漫无遮挡h纯肉亚洲资源大片| 免费无码精品黄av电影| 小雪尝禁果又粗又大的视频| 久久久av男人的天堂| 顶级欧美熟妇高潮xxxxx| 亚洲熟伦熟女新五十路熟妇| 国产精品无码一区二区桃花视频 | 久久久久国色av∨免费看 | 中文字幕av久久激情亚洲精品| 国产亚洲精品自在久久vr| 亚洲成a人片在线观看国产|