在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CLK2 Antibody

  • 中文名稱:
    CLK2兔多克隆抗體
  • 貨號:
    CSB-PA005558ESR2HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA005558ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human thymus tissue using CSB-PA005558ESR2HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CLK2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    CLK2
  • 別名:
    CDC like kinase 2 antibody; CDC-like kinase 2 antibody; CLK 2 antibody; CLK kinase antibody; CLK2 antibody; Clk2 Scamp3 antibody; CLK2_HUMAN antibody; Dual specificity protein kinase CLK2 antibody; hCLK 2 antibody; hCLK2 antibody; Tu52 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Dual specificity protein kinase CLK2 protein (240-499AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Phosphorylates PAGE4 at several serine and threonine residues and this phosphorylation attenuates the ability of PAGE4 to potentiate the transcriptional activator activity of JUN.
  • 基因功能參考文獻:
    1. These findings suggest that CLK2 plays a critical role in controlling the cell cycle and survival of glioblastoma PMID: 27050366
    2. Loss of CLK2 in luminal breast cancer cells leads to the upregulation of epithelial-to-mesenchymal transition (EMT)-related genes and a switch to mesenchymal splice variants of several genes. PMID: 25670169
    3. LAMMER/Cdc2-like kinase, represented by Doa and its mammalian homolog CLK2, is a critical and conserved component in the regulatory program of the mitosis-to-meiosis switch PMID: 23376537
    4. AKT activation controls cell survival to ionizing radiation by phosphorylating CLK2, revealing an important regulatory mechanism required for promoting cell survival. PMID: 20682768
  • 亞細胞定位:
    Nucleus.; [Isoform 1]: Nucleus. Nucleus speckle.; [Isoform 2]: Nucleus speckle.
  • 蛋白家族:
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, Lammer subfamily
  • 組織特異性:
    Endothelial cells. Expressed in androgen-dependent prostate cancer cells.
  • 數據庫鏈接:

    HGNC: 2069

    OMIM: 602989

    KEGG: hsa:1196

    STRING: 9606.ENSP00000354856

    UniGene: Hs.73986



主站蜘蛛池模板: 曰本无码不卡高清av一二| 久久精品免费一区二区三区| 国产精品无码嫩草地址更新| 青青久在线视频免费观看| 色偷一区国产精品| 奇米777国产在线视频| 亚洲日韩精品无码专区加勒比海| 亚洲精品中文字幕无码蜜桃| 一区二区三区人妻无码| 亚洲中文字幕乱码av波多ji| 国产精品久久久久电影网| 国产欧美一区二区三区免费视频| 末发育娇小性色xxxxx视频| 2020最新国产在线不卡a| 麻豆视传媒官网免费观看| 亚洲人成色777777老人头| 无码无遮挡又大又爽又黄的视频| 老师黑色丝袜被躁翻了av| 337p日本欧洲亚洲大胆人人 | 国产片免费福利片永久| 国产大片黄在线观看私人影院 | 国产欧美另类精品久久久| 丝袜美腿亚洲一区二区| 亚洲中文字幕无码久久精品1| 精品国际久久久久999| 亚洲人成人一区二区三区| 欧美中日韩免费观看网站| 欧美老人巨大xxxx做受视频 | 国产精品无码嫩草地址更新| 男女做爰真人视频直播| 成在人线av无码免费高潮水老板| 高潮射精日本韩国在线播放| 国产午夜精品一区二区三区不卡 | 国产狂喷潮在线观看| 日本妇人成熟免费| 久久午夜私人影院| 国产精品免费无码二区| 在厨房拨开内裤进入毛片| 亚洲色成人网站www永久蜜芽| 亚洲精品综合欧美一区二区| 男人扒开女人腿桶到爽免费|