在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Dual specificity protein kinase CLK2 (CLK2), partial

  • 中文名稱:
    Recombinant Human Dual specificity protein kinase CLK2(CLK2),partial
  • 貨號:
    CSB-YP005558HU1
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human Dual specificity protein kinase CLK2(CLK2),partial
  • 貨號:
    CSB-EP005558HU1-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human Dual specificity protein kinase CLK2(CLK2),partial
  • 貨號:
    CSB-BP005558HU1
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human Dual specificity protein kinase CLK2(CLK2),partial
  • 貨號:
    CSB-MP005558HU1
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    CLK2
  • Uniprot No.:
  • 別名:
    CDC like kinase 2; CDC-like kinase 2; CLK 2; CLK kinase; CLK2; Clk2 Scamp3; CLK2_HUMAN; Dual specificity protein kinase CLK2; hCLK 2; hCLK2; Tu52
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    partial
  • 表達區域:
    138-499
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Phosphorylates PAGE4 at several serine and threonine residues and this phosphorylation attenuates the ability of PAGE4 to potentiate the transcriptional activator activity of JUN.
  • 基因功能參考文獻:
    1. These findings suggest that CLK2 plays a critical role in controlling the cell cycle and survival of glioblastoma PMID: 27050366
    2. Loss of CLK2 in luminal breast cancer cells leads to the upregulation of epithelial-to-mesenchymal transition (EMT)-related genes and a switch to mesenchymal splice variants of several genes. PMID: 25670169
    3. LAMMER/Cdc2-like kinase, represented by Doa and its mammalian homolog CLK2, is a critical and conserved component in the regulatory program of the mitosis-to-meiosis switch PMID: 23376537
    4. AKT activation controls cell survival to ionizing radiation by phosphorylating CLK2, revealing an important regulatory mechanism required for promoting cell survival. PMID: 20682768
  • 亞細胞定位:
    Nucleus.; [Isoform 1]: Nucleus. Nucleus speckle.; [Isoform 2]: Nucleus speckle.
  • 蛋白家族:
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, Lammer subfamily
  • 組織特異性:
    Endothelial cells. Expressed in androgen-dependent prostate cancer cells.
  • 數據庫鏈接:

    HGNC: 2069

    OMIM: 602989

    KEGG: hsa:1196

    STRING: 9606.ENSP00000354856

    UniGene: Hs.73986



主站蜘蛛池模板: 伦埋琪琪电影院久久| 国产精品自在拍首页视频| 欧美性潮喷xxxxx免费视频看| 少妇被爽到高潮动态图| 无码少妇精品一区二区免费动态| 日本一卡2卡三卡4卡免费网站| 亚洲色无码中文字幕在线| 无码人妻一区二区三区线| 天天爽夜夜爽夜夜爽精品视频| 国产成人精品自在线导航| 亚洲日本乱码中文在线电影| 国产精品久久久久久av| 亚洲最大av无码国产| 国产在线精品视频二区| 久久国产乱子伦精品免费午夜| 日日躁夜夜躁白天躁晚上| 四虎永久在线精品免费网址| 久久国产免费福利永久| 毛片无遮挡高清免费| 蜜臀av在线播放| 动漫精品啪啪一区二区三区| 国产丝袜足j在线视频播放| 爆乳高潮喷水无码正在播放 | 又大又粗又长的高潮视频| 狠狠躁天天躁夜夜躁婷婷| 双腿张开被9个男人调教| 久久激情综合狠狠爱五月| 亚洲人成网站18禁止大app| 少妇扒开粉嫩小泬视频| 国产亚洲精品ae86| 成人无码午夜在线观看| 亚洲熟妇少妇任你躁在线观看无码 | 日韩激情无码不卡码| 在线观看的网站| 久久男人av资源网站| 国产一区二区三区精品视频| 午夜精品久久久久久久99热| 麻豆果冻精东九一传媒mv| 久久日本片精品aaaaa国产| 97精品久久久久中文字幕| 免费人成视频在线观看不卡|