在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Docking protein 3 (DOK3)

  • 中文名稱:
    人DOK3重組蛋白
  • 貨號(hào):
    CSB-YP007109HU
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人DOK3重組蛋白
  • 貨號(hào):
    CSB-EP007109HU
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人DOK3重組蛋白
  • 貨號(hào):
    CSB-EP007109HU-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人DOK3重組蛋白
  • 貨號(hào):
    CSB-BP007109HU
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人DOK3重組蛋白
  • 貨號(hào):
    CSB-MP007109HU
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    DOK3
  • Uniprot No.:
  • 別名:
    Docking protein 3; DOK 3; DOK Like Protein; Dok3; DOK3_HUMAN; DOKL Pending; Downstream of tyrosine kinase 3; p62 DOK Like Protein
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度:
    full length protein
  • 表達(dá)區(qū)域:
    1-496
  • 氨基酸序列
    MTRGARLRSD ARAQLNQLSL DGGTGSGQKG KCEEFPSSLS SVSPGLEAAA LLLAVTMDPL ETPIKDGILY QQHVKFGKKC WRKVWALLYA GGPSGVARLE SWEVRDGGLG AAGDRSAGPG RRGERRVIRL ADCVSVLPAD GESCPRDTGA FLLTTTERSH LLAAQHRQAW MGPICQLAFP GTGEASSGST DAQSPKRGLV PMEENSIYSS WQEVGEFPVV VQRTEAATRC QLKGPALLVL GPDAIQLREA KGTQALYSWP YHFLRKFGSD KGVFSFEAGR RCHSGEGLFA FSTPCAPDLC RAVAGAIARQ RERLPELTRP QPCPLPRATS LPSLDTPGEL REMPPGPEPP TSRKMHLAEP GPQSLPLLLG PEPNDLASGL YASVCKRASG PPGNEHLYEN LCVLEASPTL HGGEPEPHEG PGSRSPTTSP IYHNGQDLSW PGPANDSTLE AQYRRLLELD QVEGTGRPDP QAGFKAKLVT LLSRERRKGP APCDRP
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function.
  • 基因功能參考文獻(xiàn):
    1. Mutations in DOK3 gene is associated with prostate cancer PMID: 26585945
    2. DOK2 and DOK3 expression was significantly reduced in HTLV-1-infected T cells. PMID: 27265473
    3. The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters PMID: 23223229
    4. absence of DOK3 increases LPS signaling, contributing to LPS-induced tolerance. Thus, DOK3 plays a role in TLR signaling during both naive and endotoxin-induced tolerant conditions PMID: 22761938
    5. Identification of DOK genes as lung tumor suppressors. PMID: 20139980
    6. The novel platelet adapter Dok-3 is tyrosine phosphorylated in an Src kinase-independent manner downstream of alphaIIbbeta3 in human platelets, leading to an interaction with Grb2 and SHIP-1. PMID: 19682241
    7. findings indicate that Dok-3 sequesters Grb2 from Shc and inhibits the Ras-Erk pathway downstream of PTKs PMID: 16436051

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族:
    DOK family, Type A subfamily
  • 組織特異性:
    Expressed in spleen.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 24583

    OMIM: 611435

    KEGG: hsa:79930

    STRING: 9606.ENSP00000349727

    UniGene: Hs.720849



主站蜘蛛池模板: 欧美日韩一卡2卡三卡4卡 乱码欧美孕交 | 久久九九有精品国产23百花影院 | 五十路丰满中年熟女中出| 国产无遮挡又黄又爽免费视频| 国产黄大片在线观看画质优化| 黑人巨大跨种族video| 精品无码日韩一区二区三区不卡| 亚洲中文字幕久久精品蜜桃| 很黄很色60分钟在线观看| 天天躁日日躁狠狠躁av麻豆男男| 国产精品无码一区二区三区| 日韩美女自卫慰黄网站| 中文字幕乱码熟妇五十中出色欲| 国产精品久久久久久久久ktv| 亚洲gv猛男gv无码男同| 久久婷婷丁香七月色综合| 亚洲日韩乱码中文无码蜜桃臀网站| 无码成a毛片免费| 无码人妻精品一区二区蜜桃百度| 亚洲人成无码网www电影麻豆 | 五十路熟妇亲子交尾| 天天做天天爱天天要天天| 亚洲国产成人第一天堂| 久在线观看福利视频| 国产极品美女高潮抽搐免费网站| 天堂va欧美va亚洲va好看va| 强 暴 疼 哭 处 女 身子视频| 久久综合香蕉国产蜜臀av| 国产成a人亚洲精品无码樱花| 国产av高清无亚洲| 国产亚洲精品国产福利你懂的| 国产精品久久久久久人妻精品 | 国产精品久久久| 99精品无码一区二区| 在线精品国精品国产尤物| 99精品国产一区二区三区不卡 | 欧美午夜成人片在线观看| 天天综合天天做天天综合 | 精品国产va久久久久久久冰| 精品国产三级在线观看| 一区二区三区波多野结衣在线观看|