在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human DNA excision repair protein ERCC-6-like (ERCC6L), partial

Recombinant Human DNA excision repair protein ERCC-6-like (ERCC6L), partial

  • 中文名稱：
    人ERCC6L重組蛋白
  • 貨號：
    CSB-YP650698HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人ERCC6L重組蛋白
  • 貨號：
    CSB-EP650698HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人ERCC6L重組蛋白
  • 貨號：
    CSB-EP650698HU-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人ERCC6L重組蛋白
  • 貨號：
    CSB-BP650698HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人ERCC6L重組蛋白
  • 貨號：
    CSB-MP650698HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ERCC6L
  • Uniprot No.：
  • 別名：
    ATP dependent helicase ERCC6 like; ATP-dependent helicase ERCC6-like; DNA excision repair protein ERCC 6 like; DNA excision repair protein ERCC-6-like; ERC6L_HUMAN; ERCC 6L; Ercc6l; Excision repair cross complementing rodent repair deficiency complementation group 6 like; Excision repair protein ERCC6 like; FLJ20105; MGC131695; PICH; Plk1 interacting checkpoint helicase; PLK1-interacting checkpoint helicase; SNF2/RAD54 family protein; Tumor antigen BJ HCC 15; Tumor antigen BJ-HCC-15
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro).
  • 基因功能參考文獻(xiàn)：
    1. These findings suggested that ERCC6L, which is highly expressed in breast cancer, acts as an oncogene, is involved in breast cancer development and may serve as a novel molecular target for the treatment of breast cancer. PMID: 30066865
    2. ERCC6L may stimulates cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2, and it could be a potential biomarker for cancer prognosis and target for cancer treatment. PMID: 28178669
    3. Data indicate BEND3 as a new interaction partner for PICH in mitosis, and have defined the residues within a TPR-BEN domain interface that mediate this interaction. PMID: 28977671
    4. Characterization of the NTPR and BD1 interacting domains of the human PICH-BEND3 complex has been reported. PMID: 27487930
    5. the mitotic roles of PICH and explore further the role of PICH in the timely segregation of the ribosomal DNA locus, are reported. PMID: 27565185
    6. a novel SUMO-dependent regulation of PICH's function on mitotic centromeres, is reported. PMID: 27230136
    7. PICH and Topo II cooperate to prevent chromosome missegregation events in mitosis. PMID: 26643143
    8. PICH is a SUMO-interacting protein and a mitotic SUMO substrate. PMID: 25564610
    9. PICH recognizes and stabilizes DNA under tension during anaphase, thereby facilitating the resolution of entangled sister chromatids. PMID: 23973328
    10. PICH protein was required for the correct recruitment to the centromere of active topoisomerase IIalpha, an enzyme specialized in the catenation/decatenation process. PMID: 22563370
    11. PICH binds to BLM and enables BLM localization to anaphase centromeric threads. PICH and BLM unravel centromeric chromatin and keep anaphase DNA threads mostly free of nucleosomes. PMID: 21743438
    12. the PICH-Plk1 complex plays a critical role in maintaining prometaphase chromosome architecture PMID: 20130082
    13. the spindle checkpoint failure formerly attributed to the depletion of PICH most likely reflects an off-target effect that causes the lowering of Mad2 transcript and protein. PMID: 19904549
    14. These data identify PICH as a novel essential component of checkpoint signaling. PMID: 17218258
    15. The sensitivity to depletion of topo IIalpha might be linked to structural alterations within the centromere domain, indicated by shortening of the distance across metaphase sister centromeres and persistence of PICH-coated connections. PMID: 17956945
    16. PICH phosphorylation and its ATPase activity are required for mitotic chromosome compaction through the targeting of Plk1 to chromosome arms. PMID: 18418076
    17. Functional characterization of the mouse Ercc6l ortholog. PMID: 15917148

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Chromosome, centromere. Chromosome, centromere, kinetochore. Chromosome.
  • 蛋白家族：
    SNF2/RAD54 helicase family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 20794

    OMIM: 300687

    KEGG: hsa:54821

    STRING: 9606.ENSP00000334675

    UniGene: Hs.47558



主站蜘蛛池模板： 少妇高潮灌满白浆毛片免费看 | 免费无码一区二区三区蜜桃大| 人与人性恔配视频免费| 99热久久这里只精品国产www| 亚瑟av亚洲精品一区二区| 亚洲欧美综合区自拍另类| 午夜熟女插插xx免费视频| 婷婷久久综合九色综合| 99尹人香蕉国产免费天天| 欧美成人形色生活片| 久久偷看各类wc女厕嘘嘘| 99精品国产在热久久婷婷| 国产精品美女乱子伦高| 日日日日做夜夜夜夜做无码| 97色精品视频在线观看| 国产精品一卡二卡三卡四卡| 久久国产36精品色熟妇| 777奇米四色成人影视色区| 亚洲线精品一区二区三八戒| 131美女爱做视频免费| 色窝窝无码一区二区三区成人网站 | 怡红院一区二区三区在线| 久久久久国产精品嫩草影院| 黄网站欧美内射| 麻豆精产一二三产区| 中文字幕精品久久久久人妻红杏| 久久精品国产精品国产精品污| av色综合久久天堂av色综合在 | 国色天香社区视频| 国产精品高清一区二区三区| 国产人妻鲁鲁一区二区| 亚洲 日韩 欧美 有码 在线| 午夜精品影视国产一区在线麻豆| 人妻互换一二三区激情视频| 起碰免费公开97在线视频| 五月色丁香婷婷网蜜臀av| 亚洲欧美综合精品成人网站| 国产av一区二区三区日韩| 久久国产精品免费一区二区三区 | 99久久无码私人网站| 性欧美俄罗斯极品|