在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ERCC6L Antibody

ERCC6L Antibody

  • 中文名稱：
    ERCC6L兔多克隆抗體
  • 貨號：
    CSB-PA076186
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA076186(ERCC6L Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA076186(ERCC6L Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    ERCC6L
  • 別名：
    ATP dependent helicase ERCC6 like antibody; ATP-dependent helicase ERCC6-like antibody; DNA excision repair protein ERCC 6 like antibody; DNA excision repair protein ERCC-6-like antibody; ERC6L_HUMAN antibody; ERCC 6L antibody; Ercc6l antibody; Excision repair cross complementing rodent repair deficiency complementation group 6 like antibody; Excision repair protein ERCC6 like antibody; FLJ20105 antibody; MGC131695 antibody; PICH antibody; Plk1 interacting checkpoint helicase antibody; PLK1-interacting checkpoint helicase antibody; SNF2/RAD54 family protein antibody; Tumor antigen BJ HCC 15 antibody; Tumor antigen BJ-HCC-15 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Fusion protein of Human ERCC6L
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro).
  • 基因功能參考文獻：
    1. These findings suggested that ERCC6L, which is highly expressed in breast cancer, acts as an oncogene, is involved in breast cancer development and may serve as a novel molecular target for the treatment of breast cancer. PMID: 30066865
    2. ERCC6L may stimulates cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2, and it could be a potential biomarker for cancer prognosis and target for cancer treatment. PMID: 28178669
    3. Data indicate BEND3 as a new interaction partner for PICH in mitosis, and have defined the residues within a TPR-BEN domain interface that mediate this interaction. PMID: 28977671
    4. Characterization of the NTPR and BD1 interacting domains of the human PICH-BEND3 complex has been reported. PMID: 27487930
    5. the mitotic roles of PICH and explore further the role of PICH in the timely segregation of the ribosomal DNA locus, are reported. PMID: 27565185
    6. a novel SUMO-dependent regulation of PICH's function on mitotic centromeres, is reported. PMID: 27230136
    7. PICH and Topo II cooperate to prevent chromosome missegregation events in mitosis. PMID: 26643143
    8. PICH is a SUMO-interacting protein and a mitotic SUMO substrate. PMID: 25564610
    9. PICH recognizes and stabilizes DNA under tension during anaphase, thereby facilitating the resolution of entangled sister chromatids. PMID: 23973328
    10. PICH protein was required for the correct recruitment to the centromere of active topoisomerase IIalpha, an enzyme specialized in the catenation/decatenation process. PMID: 22563370
    11. PICH binds to BLM and enables BLM localization to anaphase centromeric threads. PICH and BLM unravel centromeric chromatin and keep anaphase DNA threads mostly free of nucleosomes. PMID: 21743438
    12. the PICH-Plk1 complex plays a critical role in maintaining prometaphase chromosome architecture PMID: 20130082
    13. the spindle checkpoint failure formerly attributed to the depletion of PICH most likely reflects an off-target effect that causes the lowering of Mad2 transcript and protein. PMID: 19904549
    14. These data identify PICH as a novel essential component of checkpoint signaling. PMID: 17218258
    15. The sensitivity to depletion of topo IIalpha might be linked to structural alterations within the centromere domain, indicated by shortening of the distance across metaphase sister centromeres and persistence of PICH-coated connections. PMID: 17956945
    16. PICH phosphorylation and its ATPase activity are required for mitotic chromosome compaction through the targeting of Plk1 to chromosome arms. PMID: 18418076
    17. Functional characterization of the mouse Ercc6l ortholog. PMID: 15917148

    顯示更多

    收起更多

  • 亞細胞定位：
    Chromosome, centromere. Chromosome, centromere, kinetochore. Chromosome.
  • 蛋白家族：
    SNF2/RAD54 helicase family
  • 數據庫鏈接：

    HGNC: 20794

    OMIM: 300687

    KEGG: hsa:54821

    STRING: 9606.ENSP00000334675

    UniGene: Hs.47558



主站蜘蛛池模板： 人妻少妇精品无码专区动漫| 久久99精品久久久久久蜜芽| 日本一区午夜艳熟免费| 日韩精品久久无码中文字幕| 国产精品爽爽久久久久久竹菊| 国产成人精品一区二区视频| 再深点灬舒服灬太大了在线视频| 丰满熟女人妻一区二区三| 69久久精品无码一区二区| 国产精品嫩草影院久久| 国产精品区一区二区三在线播放 | 九九线精品视频在线观看| 亚洲丰满熟妇在线播放电影全集| 蜜臀av在线播放一区二区三区| 亚洲成av人在线播放无码| 成人午夜福利院在线观看| 免费少妇荡乳情欲视频| 大地资源网第二页免费观看| 久久国产成人免费网站| 人妻精品久久无码区| 久久午夜福利电影| 男女高潮又爽又黄又无遮挡| 国产熟妇疯狂4p交在线播放| 无码a∨高潮抽搐流白浆| 午夜福利三级理论电影| 99精品无码一区二区| 久久亚洲色www成人男男| 精品亚洲aⅴ无码一区二区三区| 亚洲成a人片在线不卡一二三区| 四虎成人精品在永久在线| 国语自产偷拍精品视频蜜芽| 在线观看老湿视频福利| 精品夜夜澡人妻无码av| 欧美综合自拍亚洲图久青草| 国产av天堂亚洲国产av天堂| 国外av无码精品国产精品| 国产成人精品免费视频大全五级| 国精产品蘑菇一区一区有限| 中文人妻熟女乱又乱精品| 中文字幕一区二区人妻电影| 亚洲开心婷婷中文字幕|