在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ERCC6L Antibody

ERCC6L Antibody

  • 中文名稱：
    ERCC6L兔多克隆抗體
  • 貨號(hào)：
    CSB-PA007775GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    ERCC6L
  • 別名：
    ATP dependent helicase ERCC6 like antibody; ATP-dependent helicase ERCC6-like antibody; DNA excision repair protein ERCC 6 like antibody; DNA excision repair protein ERCC-6-like antibody; ERC6L_HUMAN antibody; ERCC 6L antibody; Ercc6l antibody; Excision repair cross complementing rodent repair deficiency complementation group 6 like antibody; Excision repair protein ERCC6 like antibody; FLJ20105 antibody; MGC131695 antibody; PICH antibody; Plk1 interacting checkpoint helicase antibody; PLK1-interacting checkpoint helicase antibody; SNF2/RAD54 family protein antibody; Tumor antigen BJ HCC 15 antibody; Tumor antigen BJ-HCC-15 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human ERCC6L
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro).
  • 基因功能參考文獻(xiàn)：
    1. These findings suggested that ERCC6L, which is highly expressed in breast cancer, acts as an oncogene, is involved in breast cancer development and may serve as a novel molecular target for the treatment of breast cancer. PMID: 30066865
    2. ERCC6L may stimulates cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2, and it could be a potential biomarker for cancer prognosis and target for cancer treatment. PMID: 28178669
    3. Data indicate BEND3 as a new interaction partner for PICH in mitosis, and have defined the residues within a TPR-BEN domain interface that mediate this interaction. PMID: 28977671
    4. Characterization of the NTPR and BD1 interacting domains of the human PICH-BEND3 complex has been reported. PMID: 27487930
    5. the mitotic roles of PICH and explore further the role of PICH in the timely segregation of the ribosomal DNA locus, are reported. PMID: 27565185
    6. a novel SUMO-dependent regulation of PICH's function on mitotic centromeres, is reported. PMID: 27230136
    7. PICH and Topo II cooperate to prevent chromosome missegregation events in mitosis. PMID: 26643143
    8. PICH is a SUMO-interacting protein and a mitotic SUMO substrate. PMID: 25564610
    9. PICH recognizes and stabilizes DNA under tension during anaphase, thereby facilitating the resolution of entangled sister chromatids. PMID: 23973328
    10. PICH protein was required for the correct recruitment to the centromere of active topoisomerase IIalpha, an enzyme specialized in the catenation/decatenation process. PMID: 22563370
    11. PICH binds to BLM and enables BLM localization to anaphase centromeric threads. PICH and BLM unravel centromeric chromatin and keep anaphase DNA threads mostly free of nucleosomes. PMID: 21743438
    12. the PICH-Plk1 complex plays a critical role in maintaining prometaphase chromosome architecture PMID: 20130082
    13. the spindle checkpoint failure formerly attributed to the depletion of PICH most likely reflects an off-target effect that causes the lowering of Mad2 transcript and protein. PMID: 19904549
    14. These data identify PICH as a novel essential component of checkpoint signaling. PMID: 17218258
    15. The sensitivity to depletion of topo IIalpha might be linked to structural alterations within the centromere domain, indicated by shortening of the distance across metaphase sister centromeres and persistence of PICH-coated connections. PMID: 17956945
    16. PICH phosphorylation and its ATPase activity are required for mitotic chromosome compaction through the targeting of Plk1 to chromosome arms. PMID: 18418076
    17. Functional characterization of the mouse Ercc6l ortholog. PMID: 15917148

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Chromosome, centromere. Chromosome, centromere, kinetochore. Chromosome.
  • 蛋白家族：
    SNF2/RAD54 helicase family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 20794

    OMIM: 300687

    KEGG: hsa:54821

    STRING: 9606.ENSP00000334675

    UniGene: Hs.47558



主站蜘蛛池模板： 国产精品久久久久蜜臀| 日韩欧美偷拍高跟鞋精品一区| 国产区精品一区二区不卡中文| 又紧又黄的免费视频网站| 亚洲国产三级在线观看| 久久久久成人精品无码| 又黄又爽又无遮挡免费的网站| 国产精品无码素人福利| 人妻天天爽夜夜爽精品视频 | av片在线观看| 人妻 日韩 欧美 综合 制服| 久久久无码人妻精品无码| 日本中文字幕乱码aa高清电影| 人人爽人人澡人人人妻、百度| 国产精品国产三级国快看| 国产精品秘入口18禁麻豆免会员| 国产精品理论片在线观看| 亚洲乱码在线卡一卡二卡新区豆瓣| 又色又爽又黄的视频国内 | 成人电线在线播放无码| 国产精品高潮呻吟av久久黄 | 99久热国产精品视频尤物| 一本色道久久99一综合| 无码av中文字幕久久专区| 国产在热线精品视频99公交| 国产婷婷丁香五月缴情成人网| 欧美性黑人极品hd| 污污内射在线观看一区二区少妇| 久久精品人妻一区二区三区| 日本真人边吃奶边做爽动态图| 亚洲 日韩 国产欧美 另类| 熟妇人妻va精品中文字幕| 精品国产免费一区二区三区| 亚洲免费福利在线视频| 亚洲肥老太bbw中国熟女| 日本最新免费二区三区| 一区二区精品视频日本| 亚洲国产成人无码精品| 国产精品无码免费播放| 日韩欧无码一二三区免费不卡 | 国产精品成人免费视频网站京东|