在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Cerebellin-1 (CBLN1)

  • 中文名稱:
    Recombinant Human Cerebellin-1(CBLN1)
  • 貨號:
    CSB-YP004582HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human Cerebellin-1(CBLN1)
  • 貨號:
    CSB-EP004582HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Human Cerebellin-1(CBLN1)
  • 貨號:
    CSB-EP004582HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human Cerebellin-1(CBLN1)
  • 貨號:
    CSB-BP004582HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human Cerebellin-1(CBLN1)
  • 貨號:
    CSB-MP004582HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    [des-Ser1]-cerebellin; CBLN 1; CBLN1; CBLN1_HUMAN; CER; Cerebellin 1; Cerebellin 1 precursor; Cerebellin1; Precerebellin
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    22-193
  • 氨基酸序列
    QNETEPIVL EGKCLVVCDS NPTSDPTGTA LGISVRSGSA KVAFSAIRST NHEPSEMSNR TMIIYFDQVL VNIGNNFDSE RSTFIAPRKG IYSFNFHVVK VYNRQTIQVS LMLNGWPVIS AFAGDQDVTR EAASNGVLIQ MEKGDRAYLK LERGNLMGGW KYSTFSGFLV FPL
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the matching and maintenance of pre- and post-synaptic elements at parallel fiber-Purkinje cell synapses, the establishment of the proper pattern of climbing fiber-Purkinje cell innervation, and induction of long-term depression at parallel fiber-Purkinje cell synapses. Plays a role as a synaptic organizer that acts bidirectionally on both pre- and post-synaptic components. On the one hand induces accumulation of synaptic vesicles in the pre-synaptic part by binding with NRXN1 and in other hand induces clustering of GRID2 and its associated proteins at the post-synaptic site through association of GRID2. NRXN1-CBLN1-GRID2 complex directly induces parallel fiber protrusions that encapsulate spines of Purkinje cells leading to accumulation of GRID2 and synaptic vesicles. Required for CBLN3 export from the endoplasmic reticulum and secretion. NRXN1-CBLN1-GRID2 complex mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis. Essential for long-term maintenance but not establishment of excitatory synapses. Inhibits the formation and function of inhibitory GABAergic synapses in cerebellar Purkinje cells.; The cerebellin peptide exerts neuromodulatory functions. Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release.
  • 基因功能參考文獻:
    1. Cbln1 and Cbln2 are co-expressed in the endolysosomal compartment of the thalamic neurons responsible for the synaptic alterations in striatum of Cbln1-null mice. PMID: 22117778
  • 亞細胞定位:
    Secreted. Cell junction, synapse, postsynaptic cell membrane.
  • 組織特異性:
    In the Purkinje cells postsynaptic structures. In the cerebellum, cerebellin is much less abundant than [des-Ser1]-cerebellin.
  • 數據庫鏈接:

    HGNC: 1543

    OMIM: 600432

    KEGG: hsa:869

    STRING: 9606.ENSP00000219197

    UniGene: Hs.458423



主站蜘蛛池模板: 中文字幕 制服 亚洲 另类| 亚洲综合久久成人a片红豆| 在线观看精品视频网站| 亚洲成a人v欧美综合天堂| 亚欧美无遮挡hd高清在线视频| 久久精品国产99久久香蕉| 国产1卡二卡3卡四卡乱码视频| 免费人成视频19674不收费| 欧美freesex黑人又粗又大| 最新永久无码av网址亚洲| 精品国产免费人成电影在线看| 亚洲 丝袜 另类 校园 欧美| 亚洲国产成人精品无码区99| 精品香蕉久久久午夜福利| 青青草在在观免费福利线观看| 扒开女人内裤猛进猛出免费视频| 美女啪啪网站又黄又免费| 水蜜桃精品一二三| 国产成年女人毛片80s网站| 精品国产精品国产偷麻豆| 内射人妻无套中出无码| 少妇扒开双腿让我看个够| 少妇高潮太爽了在线视频| 国产成人精品无码专区| 青青青草国产线观| 国产美女精品视频线免费播放软件| 精品午夜福利无人区乱码一区| 欧美性猛交xxxx富婆| 色欲来吧来吧天天综合网| 国产偷窥熟女高潮精品视频| 久久综合九色欧美综合狠狠| 少妇人妻大乳在线视频不卡| 国产精品久久久久影院色| 国产精品免费精品自在线观看| 人人妻人人澡人人爽国产| 男女一边摸一边做爽爽的免费阅读| 国模冰莲自慰肥美胞极品人体图 | 男人扒开女人双腿猛进视频| 亚洲婷婷五月激情综合app| 国产精品福利自产拍久久| 无码人妻丰满熟妇区五十路|